Ion Emission from Water Ice Due to Energetic Particle Bombardment

Wojciechowski, I.A.; Sun, Shilong; Szakal, Christopher; Winograd, Nicholas; Garrison, Barbara J.

doi:10.1021/jp0373696

Cited by 24 publications

(31 citation statements)

References 38 publications

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“…Thus, the creation of new ions and attachment of the new ions to the molecule is possible. Moreover, the same simulations (Ryan et al, 2007) as well as the study of pre‐formed ions by Wojciechowski et al (2004a,b) show that recombination of near‐by ions to form neutral species is very probable. In addition to the formation of parent (M + H) + ions the model should, therefore, predict all the water cluster distributions mentioned above.…”

Section: Ionizationmentioning

confidence: 72%

“…They find that free matrix ions are formed in both the desorption and ablation regime although as discussed above, they find that the analyte ions remain embedded in clusters composed of matrix molecules throughout the simulation time (several nanosecond). In the second study, Wojciechowski and co‐workers examined the emission of pre‐formed salt ions from a water matrix in SIMS in a joint computation and experimental study (Wojciechowski et al, 2004a,b) They found experimentally that for over four orders of magnitude of salt concentration the ion intensities are relatively constant and more cations are emitted than anions. Moreover, for 1 M solutions the bare ion (e.g., Na + or I − ) is the predominant species over hydrated ions.…”

Section: Ionizationmentioning

confidence: 99%

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Computational view of surface based organic mass spectrometry

Garrison

Postawa

2008

Mass Spectrometry Reviews

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147

204

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Surface based mass spectrometric approaches fill an important niche in the mass analysis portfolio of tools. The particular niche depends on both the underlying physics and chemistry of molecule ejection as well as experimental characteristics. In this article, we use molecular dynamics computer simulations to elucidate the fundamental processes giving rise to ejection of organic molecules in atomic and cluster secondary ion mass spectrometry (SIMS), massive cluster impact (MCI) mass spectrometry, and matrix‐assisted laser desorption ionization (MALDI) mass spectrometry. This review is aimed at graduate students and experimental researchers. © 2008 Wiley Periodicals, Inc., Mass Spec Rev 27: 289–315, 2008

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Section: Ionizationmentioning

confidence: 72%

Section: Ionizationmentioning

confidence: 99%

Computational view of surface based organic mass spectrometry

Garrison

Postawa

2008

Mass Spectrometry Reviews

Self Cite

147

204

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“…Donsig and Vickerman9 have reported a doubling or tripling of the (H 2 O) n H + yield compared with that of (H 2 O)

_{italicn}^{+}

after exposure of an ice film to gaseous HCl. Frozen salt solutions under C

_{60}^{+}

bombardment show that the emission of cationic water clusters is more prevalent than that of anionic water clusters 18. It seems clear that the rise in (H 2 O)H + reflects higher emission yields of protons probably near the impact site as a consequence of higher concentrations of protons in the ice film.…”

Section: Resultsmentioning

confidence: 98%

Is proton cationization promoted by polyatomic primary ion bombardment during time‐of‐flight secondary ion mass spectrometry analysis of frozen aqueous solutions?

Conlan

Lockyer

Vickerman

2006

Rapid Comm Mass Spectrometry

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Ion bombardment of pure water ice by Au+ monoatomic and Au3 + and C60 + polyatomic projectiles results in the emission of two series of water cluster ions-(H2O)n + and (H2O)nH+-with n ranging from 1 to >40. The cluster ion yields are very significantly higher under polyatomic ion bombardment than when using an Au+ primary ion. The yield of the protonated water species (H2O)nH+ is found to be enhanced by increasing ion fluence. C60 + bombardment results in a very dramatic increase in the (H2O)nH+ yield and decrease in the yield of (H2O)n +. Au3 + also significantly increased the yield of protonated species relative to the non-protonated but to a lesser extent than C60 +. Bombardment by Au+ also increased the yield of protonated species but to a very much smaller extent. The hypothesis that the protonated species may enhance the yield of [M+H]+ from solute molecules in solution has been investigated using two amino acids, alanine and arginine, and a nucleic base, adenine. The data suggest that the protons produced by the sputtering of water ice are depleted in the presence of these solutes and concurrently the yields of solute-related [M+H]+ and immonium secondary ions are greatly enhanced. These yield enhancements are analysed in the light of other possible contributors such as increased rates of sputtering under polyatomic beams and increased secondary ion yields as a consequence of solute dispersion. It is concluded that enhanced proton attachment is occurring in polyatomic sputtered frozen aqueous solutions.

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“…Incorporated water plays an important role in determining the yield of negatively charged monatomic species. Water ice drastically reduced the SI yields of negative ions compared to positive monatomic ions in computational studies [ 59 , 60 ], and this may explain why the SI intensities were lower in the FH cells. The insignificant decrease in the OH - intensity was not surprising as it is a water fragment.…”

Section: Resultsmentioning

confidence: 99%

Characterization of sample preparation methods of NIH/3T3 fibroblasts for ToF-SIMS analysis

Robinson

Castner

2013

Biointerphases

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The information that is obtained from single cells during ToF-SIMS analysis is influenced by the method that was used to prepare the cells. The removal of extracellular media before analysis is necessary, but the rinsing technique should not damage the plasma membrane of the cell. The presence of intracellular salts reduced the secondary ion yield an average of 2.6-fold during Bi3+/C60++ depth profiles. Chemical fixation followed by rinsing removed a majority of the intracellular salts, “recovering” the positive secondary ion yields. The formaldehyde-fixation process removed a majority of the intracellular Cl−, but other key anions were not removed in significant amounts. The data presented here is consistent the anion neutralization mechanism largely responsible for the lower ion yields. All of the organic secondary ions that were detected in the freeze-dried cells were also detected in the formaldehyde-fixed cells, suggesting that the fixation process did not remove any molecular species to an extent that is detectable by ToF-SIMS. Compared to freeze dried cells, well preserved, frozen-hydrated cells showed little increase, or a decreased yield, for most low mass ions, but an increased yield for larger mass fragments. This is consistent with a reduced damage cross section at cryogenic analysis temperatures, although proton donation from water and reduction the salt effects in the presence of water likely also play roles. Numerous ions detected from the frozen-hydrated cells were not detected from the freeze dried cells, however many of these ions were attributed to chemical combinations of water, salts and the ammonium acetate rinsing solution.

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Ion Emission from Water Ice Due to Energetic Particle Bombardment

Cited by 24 publications

References 38 publications

Computational view of surface based organic mass spectrometry

Computational view of surface based organic mass spectrometry

Is proton cationization promoted by polyatomic primary ion bombardment during time‐of‐flight secondary ion mass spectrometry analysis of frozen aqueous solutions?

Characterization of sample preparation methods of NIH/3T3 fibroblasts for ToF-SIMS analysis

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