Ion-exchange reactions between acid mucopolysaccharides and various cations

One-Step Surface Modification of Poly(lactide-co-glycolide) Microparticles with Heparin

“…The results here indicated that binding of divalent cations to the heparin chain is stronger than that of univalent ions, which is consistent with the results derived from the ionexchange reaction and methylene blue replacement (31,32). 0.15 M NH 4 Cl, with NH þ 4 at the same concentration as in ammonium heparin, resulted in a pH of 5.2, suggesting the additional pH drop to 4.0 in ammonium heparin was due to NH þ 4 binding to heparin chain.…”

Mechanosensitive and Olfactory Sensilla of Insects

“…These, in turn, can cross-link macromolecules like hyaluronic acid, causing them to form aggregates of high complexity; they also can bind water molecules to the chains (Winter and Arnott, 1977). Dunstone (1962) claims that cations can remain more or less free and able to move if merely attracted by weak electrostatic forces.…”

A potentiometric titration study of the interaction of heparin with metal cations

“…The work of Dunstone (1962) suggested the paramount importance of the value of solution ionic strength (I) in determining the strength ofcation binding to glycosaminoglycans. It was therefore of interest to determine the effect of a variation of I on the potentiometric titration of heparin in the presence of a variety of cations; a strong dependence of binding on I would accord with an important role for electrostatic interaction in the binding, as predicted by ion-condensation concepts (Manning, 1969a(Manning, ,b,c, 1977(Manning, , 1978 (a) CuSO4,5H20 solution in water was added to 30 ml of a solution of Li+-heparin (0.25 mg/ml) in water, to give the following final Cu2+/heparin disaccharide ratios: 0, 0; *, 0.29; EO, 2.20; *, 4.30 (in a volume of 30 ml).…”