Ion image sensors and their application for visualization of neural activity

Abstract

One of the merits of fusing LSI technology with sensor technology is arraying. The LSI sensor technology can array more than 1000 devices, enabling it to be used as a tool for visualization. Among the five senses of human beings, the eyes provide about 80%. By visualizing a phenomenon, it is easy to understand it intuitively. The fusion of sensor technology with LSI technology is changing the role of sensors from “tools for measurement” to “tools for understanding”. In the biomedical field, imaging technology has become important for understanding information obtained from organic activity. Solid-state-type bio image sensors fusing biosensor technology with CMOS technology are attractive devices for use as bio/chemical imaging tools, because an optical image sensor combining photodiodes and CMOS readout circuits can be fabricated with state-of-the art technology. CMOS-based bio-image sensors have the potential to acquire the local distribution of neurotransmitters, ions, and chemical species in a solution and organic matter without optical labels.

State-space modeling for dynamic response of graphene FET biosensors

“…Since the introduction of ion-sensitive field effect transistors (ISFETs) in 1970, 1) FET-based biosensors have attracted significant interest owing to their promising potential for a wide range of applications. 2,3) In particular, graphene films offer an ideal sensing platform owing to their high electron/ hole mobilities 4) and 2D nature, 5) and thus graphene field effect transistor (G-FET) biosensors have been used to detect ions, 6) biomolecules, 7) and bacteria. 8) However, a baseline drift is observed in the response of FET-based sensors, 9,10) particularly in the case of G-FET biosensors because of their high sensitivity.…”