Ion-incorporated titanium implants for staged regulation of antibacterial activity and immunoregulation-mediated osteogenesis

Wu, Bingfeng; Tang, Yufei; Yao, Keyi; Luo, Xin; Feng, Shuqi; Wang, Kai; Zhou, Xuemei; Xiang, Lin

doi:10.1039/d3nr05858a

Cited by 3 publications

(1 citation statement)

References 55 publications

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“…Excessive inflammatory response often leads to active osteoclasts, poor bone healing, or alveolar bone resorption, which would cause implant failure. An appropriate inflammatory response, on the other hand, is conducive to the removal of foreign body pathogens, and inflammatory factors such as nitric oxide can also promote vascular regeneration [6,7]. Therefore, the osseointegration process of implants may depend on a balanced and controllable immune response.…”

Section: Introductionmentioning

confidence: 99%

Effect of graphene oxide loaded on TiO₂-nanotube-modified Ti on inflammatory responses

Cao,

Luo,

Wang

et al. 2024

Phys. Scr.

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Although a titanium matrix modified with titanium dioxide nanotube (TNT) arrays can have anti-inflammatory effects in vitro, these effects are limited. In this study, the TNT surface was modified by electrodepositing graphene oxide (GO) to enhance the anti-inflammatory effect of the material. Scanning electron microscopy (SEM), Raman spectroscopy, and X-ray diffraction were used to characterize each of these materials. Cell Counting Kit-8 (CCK-8) was used to determine the cell proliferation status. Enzyme-linked Immunosorbent Assay (ELISA), immunofluorescence staining, and RNA sequencing were used to assess the regulation of inflammation in each group. Raman spectroscopy confirmed that GO was successfully loaded onto the surface. The SEM, ELISA, fluorescence staining, and RNA sequencing results indicated that TNT-GO can effectively inhibit the inflammatory response and induce the M2 polarization of macrophages. TNT-GO can weaken the surface inflammatory responses of materials, suppress the secretion of pro-inflammatory factors, and promote the M2 polarization of macrophages. These advantageous properties render TNT-GO a promising material for dental implants.

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Section: Introductionmentioning

confidence: 99%

Effect of graphene oxide loaded on TiO₂-nanotube-modified Ti on inflammatory responses

Cao,

Luo,

Wang

et al. 2024

Phys. Scr.

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Biomimetic Mineralized Collagen Scaffolds for Bone Tissue Engineering: Strategies on Elaborate Fabrication for Bioactivity Improvement

Wu,

Li,

Wang

et al. 2024

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Biomimetic mineralized collagen (BMC) scaffolds represent an innovative class of bone‐repair biomaterials inspired by the natural biomineralization process in bone tissue. Owing to their favorable biocompatibility and mechanical properties, BMC scaffolds have garnered significant attention in bone tissue engineering. However, most studies have overlooked the importance of bioactivity, resulting in collagen scaffolds with suboptimal osteogenic potential. In this review, the composition of the mineralized extracellular matrix (ECM) in bone tissue is discussed to provide guidance for biomimetic collagen mineralization. Subsequently, according to the detailed fabrication procedure of BMC scaffolds, the substances that can regulate both the fabrication process and biological activities is summarized. Furthermore, a potential strategy for developing BMC scaffolds with superior mechanical properties and biological activities for bone tissue engineering is proposed.

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The relationship between the secondary implant stability quotient and oxidized implant-related factors: A retrospective study

Alzoubi,

Alhumaidan,

AlRumaih

et al. 2024

Heliyon

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Ion-incorporated titanium implants for staged regulation of antibacterial activity and immunoregulation-mediated osteogenesis

Abstract: Antibacterial property and osteogenic activity are considered as two crucial factors for the initial healing and long-term survivability of orthopedic implants. For decades, various drug-loaded implants to enhance biological activities...

Cited by 3 publications

References 55 publications

Effect of graphene oxide loaded on TiO₂-nanotube-modified Ti on inflammatory responses

Effect of graphene oxide loaded on TiO₂-nanotube-modified Ti on inflammatory responses

Biomimetic Mineralized Collagen Scaffolds for Bone Tissue Engineering: Strategies on Elaborate Fabrication for Bioactivity Improvement

The relationship between the secondary implant stability quotient and oxidized implant-related factors: A retrospective study

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Ion-incorporated titanium implants for staged regulation of antibacterial activity and immunoregulation-mediated osteogenesis

Abstract: Antibacterial property and osteogenic activity are considered as two crucial factors for the initial healing and long-term survivability of orthopedic implants. For decades, various drug-loaded implants to enhance biological activities...

Cited by 3 publications

References 55 publications

Effect of graphene oxide loaded on TiO2-nanotube-modified Ti on inflammatory responses

Effect of graphene oxide loaded on TiO2-nanotube-modified Ti on inflammatory responses

Biomimetic Mineralized Collagen Scaffolds for Bone Tissue Engineering: Strategies on Elaborate Fabrication for Bioactivity Improvement

The relationship between the secondary implant stability quotient and oxidized implant-related factors: A retrospective study

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Product

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Effect of graphene oxide loaded on TiO₂-nanotube-modified Ti on inflammatory responses

Effect of graphene oxide loaded on TiO₂-nanotube-modified Ti on inflammatory responses