Ion-modulated interfacial fluorescence in droplet microfluidics using an ionophore-doped oil

Wang, Renjie; Ghanbari Ghalehjoughi, Nasrin; Wang, Xuewei

doi:10.1039/d3cc02945j

Chem. Commun.

2023

DOI: 10.1039/d3cc02945j

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Ion-modulated interfacial fluorescence in droplet microfluidics using an ionophore-doped oil

Renjie Wang,

Nasrin Ghanbari Ghalehjoughi,

Xuewei Wang

Abstract: The extraction of ions from aqueous microdroplets into oil segments exchanges dye molecules to oil–water interfaces to generate localized fluorescence.

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2024

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Cited by 2 publications

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Plasticizer-based and polymer-free ion-selective optodes on cellulose paper

Li,

Thompson,

Wang

2024

Sensors and Actuators B: Chemical

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Plasticizer-based and polymer-free ion-selective optodes on cellulose paper

Li,

Thompson,

Wang

2024

Sensors and Actuators B: Chemical

View full text Add to dashboard Cite

Ionophore-Based SERS Sensing for Electrolyte Cations

Grewal,

Ricca,

Zhang

et al. 2024

Anal. Chem.

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We present here a surface-enhanced Raman spectroscopy (SERS)-based platform for selectively detecting electrolyte cations. This platform facilitates the reorientation of the chromoionophore I (CHI) molecule positioned on the surface of silver nanoparticles, regulated by the targeted electrolyte cation within the ionophore-based ion-selective sensing framework. When exposed to the target ions, leading to deprotonation, the aromatic plane of the CHI molecule shifts from an endwise to an edgewise configuration on the SERS substrate surface. This reorientation improves the coupling of the induced dipole within the molecule and the induced electromagnetic field normal to the surface, leading to a heightened and more discernible SERS signal. Additionally, NMR data revealed a protonation-dependent conformational change in the CHI molecules. Upon protonation, the side chain of the CHI molecule extends away from its aromatic ring, whereas upon deprotonation, the carbon chain folds back and closely approaches the edge of the aromatic plane, further confirming this conclusion. Using Ca 2+ and Na + as examples, this method shows a detection limit of 0.1 μM for Ca 2+ and 1 μM for Na + with high selectivity. The successful application of the versatile and rapidly advancing SERS technique for electrolyte cation detection shows a promising pathway for enhancing current ion detection capabilities. As a preliminary demonstration, the total Ca 2+ concentration in undiluted human serum was successfully determined, with common matrix interference effectively circumvented.

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Ion-modulated interfacial fluorescence in droplet microfluidics using an ionophore-doped oil

Abstract: The extraction of ions from aqueous microdroplets into oil segments exchanges dye molecules to oil–water interfaces to generate localized fluorescence.

Cited by 2 publications

References 36 publications

Plasticizer-based and polymer-free ion-selective optodes on cellulose paper

Plasticizer-based and polymer-free ion-selective optodes on cellulose paper

Ionophore-Based SERS Sensing for Electrolyte Cations

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