Ion–molecule reactions and dissociation of glycols in a quadrupole ion trap mass spectrometer: Evidence of intramolecular interactions

Eichmann, Erika S.; Brodbelt, Jennifer S.

doi:10.1002/oms.1210280703

Cited by 22 publications

(18 citation statements)

References 19 publications

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“…It was also noted that rearrangement to form so-called C ions, corresponding to elimination of internal monomer units, was negligible from ECD. Such rearrangement commonly occurs in CID (Lattimer, 1992;Eichmann & Brodbelt, 1993;Selby, Wesdemiotis, & Lattimer, 1994).…”

Section: A Electron Capture Dissociation Of Polymersmentioning

confidence: 98%

The role of electron capture dissociation in biomolecular analysis

Cooper¹,

Håkansson²,

Marshall³

2004

Mass Spectrometry Reviews

477

472

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The introduction of electron capture dissociation (ECD) to electrospray (ESI) Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) constitutes a significant advance in the structural analysis of biomolecules. The fundamental features and benefits of ECD are discussed in this review. ECD is currently unique to FT-ICR MS and the fundamentals of that technique are outlined. The advantages and complementarity of ECD in relation to other tandem mass spectrometry (MS/MS) techniques, such as infrared multiphoton dissociation (IRMPD) and sustained off-resonance collision-induced dissociation (SORI-CID), are discussed. The instrumental considerations associated with implementation of ECD, including activated ion techniques and coupling to on-line separation techniques, are covered, as are the allied processes electronic excitation dissociation (EED), electron detachment dissociation (EDD), and hot electron capture (HECD). A major theme of this review is the role of ECD in proteomics, particularly for characterization of post-translational modifications (phosphorylation, glycosylation, carboxyglutamic acid, sulfation, acylation, and methionine oxidation) and the top-down approach to protein identification. The application of ECD to the analysis of polymers, peptide nucleic acids, and oligonucleotides is also discussed.

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Section: A Electron Capture Dissociation Of Polymersmentioning

confidence: 98%

The role of electron capture dissociation in biomolecular analysis

Cooper¹,

Håkansson²,

Marshall³

2004

Mass Spectrometry Reviews

477

472

View full text Add to dashboard Cite

show abstract

“…The base peaks in the DME CI mass spectra from the external source ITMS for these three isomers are all at m/z 119 ([M+13] + ). These [M+13] + ions can also be assigned as [M+CH] + since they are produced from the dissociations of [M+45] + complexes via elimination of one molecule of formaldehyde, according to Brodbelt's studies 12–31. In addition, the DME CI spectra obtained in the internal source ITMS (refer to Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Brodbelt et al . have examined methyne addition reactions by dimethyl ether (DME) CI in a number of systems using an ITMS and have characterized the reaction product ions using collisionally activated dissociation (CAD) and isotopic labeling 12–31. Isomer discrimination for o ‐, m ‐ and p ‐xylene using metal ions has been described by Bjarnason et al 32,33.…”

mentioning

confidence: 99%

Comparing differentiation of xylene isomers by electronic ionization, chemical ionization and self‐ion/molecule reactions and the first observation of methyne addition ions for xylene isomers in self‐ion/molecule reactions for non‐nitrogenated compounds

2003

Rapid Comm Mass Spectrometry

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This study presents the self-ion/molecule reaction (SIMR) spectra of three xylene isomers, and proposes an approach to differentiating them based on observed differences in relative abundances of ions formed by SIMR in an internal source ion trap instrument. It also demonstrates the applicability of SIMR for isomer discrimination, which is better than electron ionization (EI) and dimethyl ether chemical ionization (DME CI) in an ion trap mass spectrometer (ITMS) since no CI reagent, metal ions or internal standards are required to perform SIMR. The merits of the new method for distinguishing isomers are that it is simple, rapid and economic. To date, methyne addition products ([M+13](+) ions) have been observed for several nitrogenated compounds including aza-crown ethers, aniline and dopamine from SIMR in the ITMS. The xylene isomers are, however, the first three non-nitrogenated compounds that have been shown to produce the methyne addition ions in SIMR.

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“…SIMR leading to the formation of methyne addition reactions in an ITMS has been investigated previously 6–9. Brodbelt and co‐workers examined methyne addition reactions by dimethyl ether (DME) CI for many compounds using an ITMS 10–26. The purpose of this paper is to describe the phenomenon when CAD is performed on the methyne adduct ions produced from both SIMR or CI, using both external and internal source ITMS instruments, where the SIMR can occur and lead to the formation of the protonated molecules or adduct ions.…”

Section: Introductionmentioning

confidence: 99%

Observation of self‐ion–molecule reactions during collisionally activated dissociation in an ion‐trap mass spectrometer

Chen

2004

J. Mass Spectrom.

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This paper describes the formation of protonated molecules ([M + H]+) and adduct ions by self-ion-molecule reactions (SIMR) during collisionally activated decomposition (CAD) of methyne addition ions ([M + CH]+) produced from chemical ionization (CI) or SIMR in both an external and internal source ion-trap mass spectrometer (ITMS). The CAD results for the methyne addition ions of dopamine produced from both SIMR and dimethyl ether CI undertaken in the external and internal source ITMS were compared in order to prove the occurrence of SIMR during CAD processes. Compared with the external source ITMS, the internal source ITMS is much more easily applicable to this type of reaction owing to the large population of neutral analytes present in the trap.

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Ion–molecule reactions and dissociation of glycols in a quadrupole ion trap mass spectrometer: Evidence of intramolecular interactions

Cited by 22 publications

References 19 publications

The role of electron capture dissociation in biomolecular analysis

The role of electron capture dissociation in biomolecular analysis

Comparing differentiation of xylene isomers by electronic ionization, chemical ionization and self‐ion/molecule reactions and the first observation of methyne addition ions for xylene isomers in self‐ion/molecule reactions for non‐nitrogenated compounds

Observation of self‐ion–molecule reactions during collisionally activated dissociation in an ion‐trap mass spectrometer

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