Ion Pair Colorimetric Estimation of Dronedrone HCl in Solid Dosages Using Methyl Orange

Abstract

New ion pair colorimetric method has been developed for the estimation of dronedrone in bulk and in tablet formulation using methyl orange dye as an ion paring complexant using pH 4 buffer. The developed method has been validated for its sensitivity and specificity. The intensity of ion pair complex of dronedrone and methyl orange found linear over the range of 2-20 µg mL-1 with a correlation coefficient of 0.9958. The inter and intraday precision, accuracy, stability, LOD, LOQ, placebo interference, robustness and ruggedness were evaluated during validation. The % RSD found for the recovery of the method resulted with low value of about 0.72-0.99; and with good precision. From the results obtained the developed method was found suitable and comparable in terms of estimating dronedrone in formulation with that of existing methods.

A validated stability indicating reverses phase liquid chromatographic method for the determination of valacyclovir

“…The greater antiviral activity of acyclovir against HSV compared with VZV is due to its more efficient phosphorylation by the viral thymidine kinase. A few analytical methods have been reported for the quantitative determination of Valacyclovir using UV, 1-6 colorimetric, 7 HPTLC, 8 LC-MS 9,10 and Few HPLC methods were reported for the determination of Valacyclovir in pharmaceutical formulations [11][12][13][14][15][16][17][18][19] in biological fluids. [20][21][22][23] The objective of the work is to develop HPLC method for its estimation and validation in bulk and tablet dosage form with good accuracy, simplicity, precision and economy.…”