Ion-pair high-performance liquid chromatographic analysis of sulpyrine and its metabolites in rabbit plasma.

Itoh, Soichi; Tanabe, Kazuhisa; Furuichi, Yumi; Suzuka, Takumi; Kubo, Kazuyoshi; Yamazaki, Masaru; Kamada, Akira

doi:10.1248/cpb.32.3194

Cited by 4 publications

(1 citation statement)

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“…It is worth noting that spiking with metamizol itself, from ä Növalgin® ampoule, gives the same kind of interference as spiking with methyl-aminp-antipyrine alone. This confirms the result of Itoh et al (9) who showed that metamizol is rapidly hydrolysed in vitro, as well as in vivo. Figure 2 shows that after an usual iv.…”

Section: Effect Of Each Metabolite At C Maxsupporting

confidence: 92%

Interference of Metamizol (Dipyrone) on the Determination of Creatinine with the Kodak Dry Chemistry Slide Comparison with the Enzymatic Method from Boehringer

Bagnoud¹,

Reymond²

1993

Clinical Chemistry and Laboratory Medicine

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Summary:In order to eliminate positive interferences that take place with the Jaffe technique, the Kodak Ektachem and Boehringer Mannheim Companies have chosen an enzymatic method for the determination of creatinine in serum and urine. Pathological and clinical samples often contain metabolites in elevated concentrations or exogenous compounds such as drugs or toxic compounds. We noticed that patients receiving metamizol-containing drugs showed unusually low values of creatinine when determined with an Ektachem analyser. We investigated the effect of the main metabolites of this prodrug on the creatinine enzymatic methods of Kodak and Boehringer. We concluded that methyl-amino-antipyrine, the active substance after administration of metamizol (prop. INN) was responsible for the interference, and that no reliable determination of creatinine could be performed with these methods in the serum of patients receiving this drug.

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Section: Effect Of Each Metabolite At C Maxsupporting

confidence: 92%