Ion range estimation by using dual energy computed tomography

Hünemohr, Nora; Krauß, Bernhard; Dinkel, Julien; Gillmann, Clarissa; Ackermann, B.; Jäkel, Oliver; Greilich, Steffen

doi:10.1016/j.zemedi.2013.03.001

Cited by 51 publications

(48 citation statements)

References 27 publications

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“…Table summarizes the mean error and standard deviation as well as RMS errors on SPR for each investigated method. Our results clearly demonstrate the limitations of the use of a standard SECT calibration curve in agreement with earlier studies . We report an RMS error on SPR of 1.59% between SECT‐determined values and reference SPR.…”

Section: Resultssupporting

confidence: 91%

Experimental validation of two dual‐energy CT methods for proton therapy using heterogeneous tissue samples

et al. 2017

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The present work uses experimental measurements in a realistic clinical environment to show potential benefits of DECT for proton therapy treatment planning. Our results show clear improvements over SECT in tissue-equivalent plastic materials and animal tissues. Further work towards using Monte Carlo simulations for treatment planning with DECT data and a more detailed investigation of the uncertainties on I-value and limitations on the Bragg additivity rule could potentially further enhance the benefits of this imaging technology for proton therapy.

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Section: Resultssupporting

confidence: 91%

Experimental validation of two dual‐energy CT methods for proton therapy using heterogeneous tissue samples

et al. 2017

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“…Finally, it is worth discussing the recent interest in dual energy CT (DECT) estimation of SPR, which has been reported to be superior to conventional, single energy CT conversion . Recently in‐room CT scanners with DECT capability have become available, and several centers are now equipped with the technology .…”

Section: Beyond Anatomy‐based Positioningmentioning

confidence: 99%

Current state and future applications of radiological image guidance for particle therapy

Landry

Hua

2018

Medical Physics

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In this review paper, we first give a short overview of radiological image guidance in photon radiotherapy, placing emphasis on the fact that linac based radiotherapy has outpaced particle therapy in the adoption of volumetric image guidance. While cone beam computed tomography (CBCT) has been an established technique in linac treatment rooms for almost two decades, the widespread adoption of volumetric image guidance in particle therapy, whether by means of CBCT or in‐room CT imaging, is recent. This lag may be attributable to the bespoke nature and lower number of particle therapy installations, as well as the differences in geometry between those installations and linac treatment rooms. In addition, for particle therapy the so called shift invariance of the dose distribution rarely applies. An overview of the different volumetric image guidance solutions found at modern particle therapy facilities is provided, covering gantry, nozzle, C‐arm, and couch‐mounted CBCT as well different in‐room CT configurations. A summary of the use of in‐room volumetric imaging data beyond anatomy‐based positioning is also presented as well as the necessary corrections to CBCT images for accurate water equivalent thickness calculation. Finally, the use of non‐ionizing imaging modalities is discussed.

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“…This additional information improves the accuracy of the proton stopping power calculation using the Bethe-Bloch equation. In their follow-up theoretical work, Yang et al [28] reported that DECT combining MV and kV images yielded even better accuracy and predicted a roughly 50% reduction in RU compared to the stoichiometric method using conventional CT. More recently, a University of Heidelberg group performed an experimental study using a commercially available DECT scanner, the Siemens’ Somatom Definition Flash [29, 30]. First, I-values were parameterized as a function of Z eff for 71 tissues described in ICRU-49 [31] using I values of individual constituents and Bragg’s additivity rule.…”

Section: Physics and Biological Effectiveness Related Challenges Imentioning

confidence: 99%

Empowering Intensity Modulated Proton Therapy Through Physics and Technology: An Overview

Mohan

Das

Ling

2017

International Journal of Radiation Oncology*Biology*Physics

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Considering the clinical potential of protons attributable to their physical characteristics, interest in proton therapy has increased greatly in this century as has the number of proton therapy installations. Until recently, passively scattered proton therapy (PSPT) was used almost entirely. Notably, overall clinical results to date have not shown convincing benefit protons over photons. A rapid transition is now occurring with the implementation of the most advanced form of proton therapy, the intensity-modulated proton therapy (IMPT). IMPT is superior to PSPT and IMRT dosimetrically. However, numerous limitations exist in the present IMPT methods. In particular, compared to IMRT, IMPT is highly vulnerable to various uncertainties. In this overview we identify three major areas of current limitations of IMPT: treatment planning, treatment delivery, and motion management, and discuss current and future efforts for improvement. For treatment planning, we need to reduce uncertainties in proton range and in computed dose distributions, improve robust planning and optimization, enhance adaptive treatment planning and delivery, and consider how to exploit the variability in the relative biological effectiveness (RBE) of protons for clinical benefit. The quality of proton therapy also depends on the characteristics of the IMPT delivery systems and image-guidance. Efforts are needed to optimize the beamlet spot size for both improved dose conformality and faster delivery. For the latter, faster energy switching time and increased dose-rate are also needed. Real-time in-room volumetric imaging for guiding IMPT is in its early stages with CBCT and CT-on-rails, and continued improvements are anticipated. In addition, imaging of the proton beams themselves using, for instance, prompt gamma emissions, is being developed to determine the proton range and to reduce range uncertainty. With the realization of the advances described above, we posit that IMPT, thus empowered, will lead to substantially improved clinical results.

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Ion range estimation by using dual energy computed tomography

Cited by 51 publications

References 27 publications

Experimental validation of two dual‐energy CT methods for proton therapy using heterogeneous tissue samples

Experimental validation of two dual‐energy CT methods for proton therapy using heterogeneous tissue samples

Current state and future applications of radiological image guidance for particle therapy

Empowering Intensity Modulated Proton Therapy Through Physics and Technology: An Overview

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