Ion release from three lead-free piezoelectric ceramics and their physical and cytotoxicity characteristics

Yu, Sheng Wen; Kuo, Shu-Ting; Tuan, Wei‐Hsing; Tsai, Yu Yu; Su, Ching Hua

doi:10.1016/j.matlet.2011.07.098

Cited by 26 publications

(26 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, wettability seems to be a major factor determining the cell activity and proliferation. However, the effect of the surface chemistry must also be taken into account, especially considering that ions leach from the perovskite ferroelectric ceramics into aqueous environments as shown in Figure and in the literature …”

Section: Discussionmentioning

confidence: 99%

“…However, the effect of the surface chemistry must also be taken into account, 40 especially considering that ions leach from the perovskite ferroelectric ceramics into aqueous environments as shown in Figure 3 and in the literature. 28,29,[42][43][44] The chemical stability of surfaces in contact with biological media is extremely important since it can affect the cell activity and proliferation. 1,3,4,45 Our experiments with commercial PZT (PIC 151) indicate that the material is unstable in aqueous media.…”

Section: Discussionmentioning

confidence: 99%

“…Very recent works highlighted the potential applicability of BZT‐BCT as biocompatible nanogenerators and thin films, albeit no investigation of topo‐physical features and chemical stability has been done. Several KNN‐based materials with remarkable piezoelectric properties have also been reported, although their processing remains challenging and cytotoxicity of several compositions did not reveal promising results …”

Section: Introductionmentioning

confidence: 99%

“…Several KNN-based materials with remarkable piezoelectric properties have also been reported, 26 although their processing remains challenging 27 and cytotoxicity of several compositions did not reveal promising results. 28,29 Taking into account the perspectives on the development of ferroelectrics as electroactive biomaterials, we investigate topography, wettability, chemical stability, and cytotoxicity of salient ferroelectric systems. We focus our experiments on NBT-6BT, BZT-60BCT, and PZT.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Cytotoxicity, chemical stability, and surface properties of ferroelectric ceramics for biomaterials

et al. 2017

View full text Add to dashboard Cite

Surface chemistry and topo-physical properties determine the interactions of biomaterials with their physiological environment. Ferroelectrics hold great promise as the next generation of scaffolds for tissue repair since they feature tunable surface electrical charges, piezoelectricity, and sensing capabilities. We investigate the topography, wettability, chemical stability, and cytotoxicity in salient ferroelectric systems such as (1Àx) (Na 1/2 Bi 1/2 )TiO 3 -xBaTiO 3 , (1Àx) showed the greatest potential leading to a cell viability of (149 AE 30)% and DNA synthesis of (299 AE 85)% in comparison to the reference. Lead leaching from Pb (Zr,Ti)O 3 negatively affected the cultured cells. Wettability and chemical stability are key factors that determine the cytotoxicity of ferroelectrics. These variables have to be considered in the design of novel electroactive scaffolds based on ferroelectric ceramics.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cytotoxicity, chemical stability, and surface properties of ferroelectric ceramics for biomaterials

et al. 2017

View full text Add to dashboard Cite

show abstract

“…While, lead zirconate titanate (PZT) ceramics show excellent piezoelectric properties with a high piezoelectric constant from 200-350 pC/N, they cannot be used as a biomaterial in tissue engineering applications, due to their cytotoxicity [10]. Promising candidates are lead-free piezoceramics, such as potassium sodium niobate (KNN), lithium-doped potassium sodium niobate (LKNN) and barium titanate (BaTiO 3 ) that are being investigated, while BaTiO 3 represents the most studied lead-free piezoceramic regarding the use as a biomaterial [8,9,[11][12][13]. The advantages of using BaTiO 3 as a scaffold material for bone tissue engineering have been reported through in vitro studies, as well as in vivo studies on small animals [8,9,13].…”

Section: Introductionmentioning

confidence: 99%

3D Printing of Piezoelectric Barium Titanate-Hydroxyapatite Scaffolds with Interconnected Porosity for Bone Tissue Engineering

et al. 2020

View full text Add to dashboard Cite

The prevalence of large bone defects is still a major problem in surgical clinics. It is, thus, not a surprise that bone-related research, especially in the field of bone tissue engineering, is a major issue in medical research. Researchers worldwide are searching for the missing link in engineering bone graft materials that mimic bones, and foster osteogenesis and bone remodeling. One approach is the combination of additive manufacturing technology with smart and additionally electrically active biomaterials. In this study, we performed a three-dimensional (3D) printing process to fabricate piezoelectric, porous barium titanate (BaTiO3) and hydroxyapatite (HA) composite scaffolds. The printed scaffolds indicate good cytocompatibility and cell attachment as well as bone mimicking piezoelectric properties with a piezoelectric constant of 3 pC/N. This work represents a promising first approach to creating an implant material with improved bone regenerating potential, in combination with an interconnected porous network and a microporosity, known to enhance bone growth and vascularization.

show abstract

Novel injectable calcium-magnesium phosphate cement-based composites with piezoelectric properties: advancements in bone regeneration applications

Sakar,

Ziylan Albayrak,

Karakaya

et al. 2024

J Mater Sci: Mater Electron

View full text Add to dashboard Cite

Designing a novel injectable bone cement is an important approach to the success of bone healing in minimally invasive surgeries. As natural bone has a piezoelectric property, which is crucial in bone regeneration, this study focused on the development of a novel injectable composite bone cement with piezoelectric properties. For the composite composition, calcium and zirconium doped barium titanate (BCZT) was used for its piezoelectric property, while calcium phosphate and magnesium phosphate cement (CMPC) were preferred for its bone-like properties. In this framework, first BCZT, CMPC, and their composites were prepared, and their phase structures, particle size distributions, and piezoelectric and dielectric properties were investigated. Then, the composite bone cements were prepared by mixing CMPC with BCZT in three different ratios (20%, 30%, and 40%). Next, polysorbate 80 solution was added to the cement mixtures to prepare the injectable pastes. Finally, injectability, setting time, and compressive strength of the composites were assessed. As a result, the composite bone cement containing 30% BCZT has the potential to be used as an injectable bone cement in invasive orthopedic surgery.

show abstract

Ion release from three lead-free piezoelectric ceramics and their physical and cytotoxicity characteristics

Cited by 26 publications

References 14 publications

Cytotoxicity, chemical stability, and surface properties of ferroelectric ceramics for biomaterials

Cytotoxicity, chemical stability, and surface properties of ferroelectric ceramics for biomaterials

3D Printing of Piezoelectric Barium Titanate-Hydroxyapatite Scaffolds with Interconnected Porosity for Bone Tissue Engineering

Novel injectable calcium-magnesium phosphate cement-based composites with piezoelectric properties: advancements in bone regeneration applications

Contact Info

Product

Resources

About