Ion selective liquid membrane electrode for the assay of lithium in blood serum

Metzger, Erich.; Ammann, D.; Asper, R.; Simon, W.

doi:10.1021/ac00292a032

Cited by 81 publications

(46 citation statements)

References 19 publications

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“…These Li+-selective electrodes can be used successfully in the determination of Li' activities in blood serum within the clinical concentration range using an adequate fixed ion background calibration method [16].…”

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confidence: 99%

“…It clearly does not meet the selectivity requirements with respect to Na+ [23]. The Li+/Na+ selectivity is even lower than the one of an o-NPOE/PVC membrane with the ionophore ETH 18 10 [12] [16]. Therefore, useful direct potentiometric measurements in the clinical Li' range of 0.7-1.5 mmol/l [24-261 are possible only if a fixed Na' background (0.14 mol/l) calibration is used.…”

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confidence: 99%

“…These high signal stabilities and thc short response times (ca. [20][21][22][23][24][25][26][27][28][29][30] seconds to reach the final EMF value to within 0.36 mV) make the sensor in this respect superior to the previously described membrane electrodes based on the ionophore ETH 1810 and n-NPOE as plasticizer [12] [16]. N o lifetime restrictions could be observed during a measuring period of 7 weeks.…”

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confidence: 99%

“…11 ion-selective membrane /I internal-filling soln., AgCl; Ag. The reference electrode was a double junction saturated calomel electrode (as already used in [16] Fig. 3) were carried out with the following cell type: Hg; Hg2C12, KCl(sat.…”

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confidence: 99%

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3,7‐Dioxaazelaamides as Ionophores for Lithium Ion Selective Liquid Membrane Electrodes

Metzger

Aeschimann

Egli

et al. 1986

Helvetica Chimica Acta

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Lipophilic neutral carriers were synthesized which show Li+/Na+ selectivities of up to ca. 80 in highly lipophilic liquid membranes. The sensor membranes exhibit improved response times and increased lifetimes as compared to systems described earlier. They allow reliable measurements of Li+ in blood serum within the clinical concentration range. A 1 :I Li+/ionophore complex of one representative (N,N,N,N'-tetracyclohexyl-5,5-dimethyl-3,7-dioxaazelaamide) has been prepared, and its structure was elucidated by X-ray analysis.Introduction. -Among the different neutral carrier-based membranes recommended for Li+-selective electrodes [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19], only few show acceptable Li+/Na+ selectivities for the potentiometric assay of Li' in blood serum during therapy of manic depressive psychosis

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3,7‐Dioxaazelaamides as Ionophores for Lithium Ion Selective Liquid Membrane Electrodes

Metzger

Aeschimann

Egli

et al. 1986

Helvetica Chimica Acta

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“…[5][6][7][8] Early lithium ion-selective electrodes were based on amide group type ionophores. [9][10][11][12][13] Lithium ions were determined in undiluted serum using cyclohexyl diamides based electrodes which had ISSN 1551-7012a selectivity of 80:1 for lithium over sodium ions. 12 A series of diamides based on pyridine, furan and dioxanone backbones, which have higher selectivity for lithium over sodium were prepared.…”

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Synthesis of azacrown sulfonamides via ring closing metathesis and their evaluation in lithium ion selective electrodes

Ibrahim

Behbehani

John³

et al. 2007

Arkivoc

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Ion‐Selective Electrodes With Ionophore‐Doped Sensing Membranes

Bühlmann

Chen

2012

Supramolecular Chemistry

115

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Recent work in the field of ionophore‐based ion‐selective electrodes (ISEs) has greatly improved our understanding of the thermodynamics and kinetics that describe the response and selectivity of these sensors. These efforts resulted in the lowering of detection limits from micro‐ to subpicomolar concentrations, improvements of selectivities by many orders of magnitude, and major advancements in biocompatibility and long‐term stabilities. This chapter summarizes the current state of the art for an audience that is new to the field, introducing the basic concepts of ISE theory that replaced in recent years the empirical approach of the early ISE history. It illustrates, with specific examples, the design principles of host‐guest chemistry that have been used to develop ionophores for ISEs, and describes with a minimum of equations the recently developed sophisticated concepts for the efficient use of these ionophores in ISEs. Importantly, this chapter shows not only how ionophores are used in modern potentiometry to develop new ISEs but also illustrates how ionophore‐based potentiometry can support host‐guest chemistry by providing tools to determine thermodynamic properties of ionophores, such as stoichiometries and stabilities of their complexes, using only a minimum amount of ionophore.

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Ion selective liquid membrane electrode for the assay of lithium in blood serum

Cited by 81 publications

References 19 publications

3,7‐Dioxaazelaamides as Ionophores for Lithium Ion Selective Liquid Membrane Electrodes

3,7‐Dioxaazelaamides as Ionophores for Lithium Ion Selective Liquid Membrane Electrodes

Synthesis of azacrown sulfonamides via ring closing metathesis and their evaluation in lithium ion selective electrodes

Ion‐Selective Electrodes With Ionophore‐Doped Sensing Membranes

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