Ion-transfer electroanalytical detection of perfluorooctanoic acid at a liquid–liquid micro-interface array

Abstract

Per- and polyfluoroalkyl substances (PFAS) are synthetic materials that bioaccumulate and are environmentally persistent. Due to their serious health threats, including to humans, new methods for the sensing of PFAS...

Modulating the ion-transfer electrochemistry of perfluorooctanoate with serum albumin and β-cyclodextrin

“…Effect of bovine serum albumin on the ion transfer electrochemistry of PFOA Our previous study reported that an aqueous phase at pH ≥ 4 was suitable for the ion transfer detection of PFOA at nanomolar concentrations using a µITIES array. 59 Also, the matrix effect of different sample constituents (including BSA, and β-CD) was identified. 59 Here, CV was employed to further examine the influence of BSA on the ion transfer electrochemistry of PFOA using the cell shown in Scheme 1.…”

“…59 Also, the matrix effect of different sample constituents (including BSA, and β-CD) was identified. 59 Here, CV was employed to further examine the influence of BSA on the ion transfer electrochemistry of PFOA using the cell shown in Scheme 1. CVs of 100 µM PFOA in the presence and absence of BSA at physiological concentration (∼0.6 mM) 61 are shown in Fig.…”

“…However, the reverse scan presents a peak shape, due to linear diffusion control of anionic PFOA within the pores that hold the μITIES, in agreement with our previous report. 59 Fig. 1B shows the CV of 100 μM PFOA in the presence of the physiological concentration of BSA, indicating very poor detection of PFOA.…”

“…[50][51][52][53][54] As a result, PFAS electrochemical detection and sensing has been investigated at the ITIES [55][56][57][58] including the microITIES (µITIES). 55,59 We have previously reported the sensitive detection of PFOA with this approach and identified the impact of matrix components on the electrochemical detection of PFOA. 59 These matrix effects indicated that bovine serum albumin (BSA) and β-CD bind to PFOA.…”

“…55,59 We have previously reported the sensitive detection of PFOA with this approach and identified the impact of matrix components on the electrochemical detection of PFOA. 59 These matrix effects indicated that bovine serum albumin (BSA) and β-CD bind to PFOA.…”