Ion transport through asymmetric nanopores prepared by ion track etching

Siwy, Zuzanna S.; Apel, P.Yu.; Dobrev, D.; Neumann, R.; Spohr, R.; Trautmann, C.; Voss, Kay‐Obbe

doi:10.1016/s0168-583x(03)00884-x

Cited by 176 publications

(135 citation statements)

References 9 publications

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“…Likewise do nano pores in polycarbonate (PC) foils present similar transport characteristics. In contrast, there was no fluctuation observed for pores microfabricated in polyimide (PI) by the same procedure of ion track etching [12,18]. The authors explain this difference with material properties related to imperfectly terminated polymer chains.…”

Section: S Achenbach Et Almentioning

confidence: 94%

“…The observed low noise level in the PMMA device when compared to other polymer materials can in part be attributed to micropatterning and material property models previously derived by various research groups: Ion transport properties of artificial micro/nano pores are strongly influenced by the chemical structure of the membrane as well as the microfabrication steps involved, including beam exposure and other accompanying pore development procedures [18]. For instance, the typical behaviour of the ion current versus time recorded at a constant voltage in the case of a polyethylene terephthalate (PET) membrane exhibited pronounced fluctuations with a high level of noise.…”

Section: S Achenbach Et Almentioning

confidence: 94%

“…In PET so called dangling ends are created due to the presence of ethylene components, which perform random movement, and thus fluctuations, when being immersed in a solution. The chemical structure of PI, on the other hand, is based on a planar sequence of aromatic groups, rendering a strong rigidity to the material, limiting the movement of PI polymer chains and thus fluctuations when immersed [18]. Smoothness and rigidity of the PI surface, thus, seem to be the decisive factors for a stable current.…”

Section: S Achenbach Et Almentioning

confidence: 99%

“…This can be explained by a model focusing on electrostatic interactions between ions passing through the pore and surface charge distribution on the pore walls [29]. Almost all microfabrication processes and their accompanying pore development steps leave artificial nano pores in either polymer membranes or silicon-based substrates with a net negative charge on their surface and walls [18]. The surface charge creates an asymmetric internal electrostatic potential inside the pore with a profile dependent on pore shape.…”

Section: Current-voltage (I-v) Characteristicsmentioning

confidence: 99%

“…Such polymer membranes offer increased hydrophilicity, and are also well adapted to microfluidic systems due to their low cost, flexibility, and ease of use in mass production [16,17]. These membrane materials, however, often create increased noise levels and are only a few percent successful in biomolecule detection experiments [18]. We now propose polymethyl meth acrylate (PMMA) as a novel membrane material for this kind of applications.…”

Section: Introductionmentioning

confidence: 99%

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PMMA Polymer Membrane-Based Single Cylindrical Submicron Pores: Electrical Characterization and Investigation of Their Applicability in Resistive-Pulse Biomolecule Detection

Achenbach¹,

Hashemi²,

Moazed³

et al. 2012

AJAC

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Single cylindrical submicron pores in PMMA polymer membranes are micropatterned by electron beam lithography and integrated into all PMMA-based electrophoretic flow detector systems. Pore dimensions are 450 nm in diameter and 1 μm in length. The pores are electrically characterized in aqueous KCl electrolyte, exhibiting a stable time-independent ionic current through the pore with a noise level of less than 1% of the open-pore current. The current-voltage curves are linear and scale with electrolyte concentration. The negative surface charge of the membrane over-proportionally decreases pore conductance at low electrolyte concentrations (≤0.1 M) that are still beyond those typically applied in biological experiments. Pores do not exhibit rectification of current flowing through them, allowing for operation with either polarity. To allow for detection of yet much smaller particles, the described PMMA-based system also was successfully equipped with pores of 1.5 nm instead of 450 nm in diameter. This was achieved by introducing naturally occurring biological protein pores of α-hemolysin on a lipid bi-layer into the pre-patterned PMMA membrane of an assembled PMMA-based electrophoretic flow detector system. Characteristics of translocation events of single-stranded linear plasmid DNA molecules through the pores were recorded, and ionic current deductions during biomolecule translocation were clear and distinguished. Based on the presented submicron scale open pore ionic current transport properties, as well as the observed passage of DNA molecules through protein pores inserted into PMMA membranes, our current research proposes that all PMMA electrophoretic flow detectors exhibit an excellent potential for future use as biomedical resistive-pulse sensors, as long as pore dimensions match those of biomolecules to be detected.

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Section: S Achenbach Et Almentioning

confidence: 94%

Section: S Achenbach Et Almentioning

confidence: 94%

Section: S Achenbach Et Almentioning

confidence: 99%

Section: Current-voltage (I-v) Characteristicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

PMMA Polymer Membrane-Based Single Cylindrical Submicron Pores: Electrical Characterization and Investigation of Their Applicability in Resistive-Pulse Biomolecule Detection

Achenbach¹,

Hashemi²,

Moazed³

et al. 2012

AJAC

View full text Add to dashboard Cite

show abstract

Nanoporous Membrane‐Based Microfluidic Biosensors

Prasad

Yadav

Bothara

et al. 2010

Microfluidic Devices in Nanotechnology

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Optical Gating of Photosensitive Synthetic Ion Channels

Ali

Nasir

Ramı́rez

et al. 2011

Adv Funct Materials

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4‐oxo‐4‐(pyren‐4‐ylmethoxy) butanoic acid is used as a photolabile protecting group to show the optical gating of nanofluidic devices based on synthetic ion channels. The inner surface of the channels is decorated with monolayers of photolabile hydrophobic molecules that can be removed by irradiation, which leads to the generation of hydrophilic groups. This process can be exploited in the UV‐light‐triggered permselective transport of ionic species in aqueous solution through the channels. The optical gating of a single conical nanochannel and multichannel polymeric membranes is characterised experimentally and theoretically by means of current–voltage and selective permeation measurements, respectively. It is anticipated that the integration of nanostructures into multifunctional devices is feasible and can readily find applications in light‐induced controlled release, sensing, and information processing.

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Ion transport through asymmetric nanopores prepared by ion track etching

Cited by 176 publications

References 9 publications

PMMA Polymer Membrane-Based Single Cylindrical Submicron Pores: Electrical Characterization and Investigation of Their Applicability in Resistive-Pulse Biomolecule Detection

PMMA Polymer Membrane-Based Single Cylindrical Submicron Pores: Electrical Characterization and Investigation of Their Applicability in Resistive-Pulse Biomolecule Detection

Nanoporous Membrane‐Based Microfluidic Biosensors

Optical Gating of Photosensitive Synthetic Ion Channels

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