Ion Transport through Surfactant Modified Cellulose Acetate Phthalate Membrane in Acidic Medium

Abstract

Cellulose acetate phthalate (CAP)membrane was interacted separately with aqueous HCl solution and aqueous HCl with sodium dodecyl hydrogen sulphate (SDS) as a surfactant and their characteristic properties were determined on the basis of water content, conductance-time and membrane potential data. The possibility of electrochemical modification of cellulose acetate phthalate membrane upon immobilization of the anionic surfactant (SDS) has been also explored. Variable concentration of HCl solutions were used across a cellulose acetate phthalate membrane for membrane potential. The data has been used to interpret the variation of permselectivity ,effective fixed charge density and Donnan distribution ratio of membrane.

Cosolvents in Self-Emulsifying Drug Delivery Systems (SEDDS): Do They Really Solve Our Solubility Problems?

“…Surfactants adsorb and accumulate in interfacial regions of membranes and alter the permeability of the membrane. 39 , 40 Consequently, adsorption and desorption processes as well as hydrogen bond formation between cosolvent and membrane constitute a bigger hindrance for the release of BA. Paired with low hydrophilicity (log P = 1.1) and moderate solubility in water (4 g 100 mL –1 at 25 °C), the diffusion celerity of BA from the SEDDS droplet to the aqueous release medium is additionally limited.…”

“…This sustained release is likely provided by physical and chemical interactions between the cellulose ester membrane of the dialysis tube, surfactant, and cosolvent. Surfactants adsorb and accumulate in interfacial regions of membranes and alter the permeability of the membrane ,. Consequently, adsorption and desorption processes as well as hydrogen bond formation between cosolvent and membrane constitute a bigger hindrance for the release of BA.…”