Ion transporters: emerging agents for anticancer therapy

Yan, Tengfei; Zheng, Xin; Liu, Shengda; Zou, Yingping

doi:10.1007/s11426-022-1258-4

Cited by 30 publications

(7 citation statements)

References 85 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been reported that disrupting the intracellular homeostasis by synthetic ion transporters would triggers cell apoptosis via the caspase‐dependent signaling pathway [4a–b] . We first investigated the underlying mechanism accounting for our channel‐induced cancer cell death using the dead cell apoptosis kit.…”

Section: Resultsmentioning

confidence: 99%

Non‐Covalently Stapled H⁺/Cl⁻ Ion Channels Activatable by Visible Light for Targeted Anticancer Therapy

Zhong,

Cao,

Xie

et al. 2023

Angew Chem Int Ed

View full text Add to dashboard Cite

The development of stimuli‐responsive artificial H+/Cl‐ ion channels, capable of specifically disturbing the intracellular ion homeostasis of cancer cells, presents an intriguing opportunity for achieving high selectivity in cancer therapy. Herein, we describe a novel family of non‐covalently stapled self‐assembled artificial channels activatable by biocompatible visible light at 442 nm, which enables the co‐transport of H+/Cl‐ across the membrane with H+/Cl‐ transport selectivity of 6.0. Upon photoirradiation of the caged C4F‐L for 10 min, 90% of ion transport efficiency can be restored, giving rise to a 10.5‐fold enhancement in cytotoxicity against human colorectal cancer cells (IC50 = 8.5 μM). The mechanism underlying cancer cell death mediated by the H+/Cl‐ channels involves the activation of the caspase 9 apoptosis pathway as well as the scarcely reported disruption of the autophagic processes. In the absence of photoirradiation, C4F‐L exhibits minimal toxicity towards normal intestine cells, even at a concentration of 200 μM.

show abstract

Section: Resultsmentioning

confidence: 99%

Non‐Covalently Stapled H⁺/Cl⁻ Ion Channels Activatable by Visible Light for Targeted Anticancer Therapy

Zhong,

Cao,

Xie

et al. 2023

Angew Chem Int Ed

View full text Add to dashboard Cite

show abstract

“…It also has potential applications in drug delivery, and range of therapeutic activities. It has been studied for its potential therapeutic activity, particularly as an anticancer agent [35][36][37] . Calix [4]pyrrole is a potential option for further research as an anticancer drug due to its ability to cause apoptosis (programmed cell death) in cancer cells when CK2 is inhibited.…”

Section: Calix[4]pyrroles and Anti-cancer Activitymentioning

confidence: 99%

Exploring the Expanding Frontiers: The Promising Role of Supramolecules in Advancing Cancer and Infectious Disease Therapy

Parmar,

Bhatt

2023

Orient. J. Chem

View full text Add to dashboard Cite

The use of calixpyrrole derivatives as potential anticancer and antibacterial agents has recently gained significant attention. We summarise recent advances in the design and production of calixpyrrole-based compounds as well as their biological actions against cancer and bacterial cells, in this overview. The structure-activity relationships (SAR) of these compounds and their mechanisms of action are discussed, highlighting their potential as therapeutic agents. Furthermore, we discuss the challenges and opportunities associated with the development of calixpyrrole-based agents as effective anticancer and antibacterial drugs. Overall, this review provides valuable insights into the development of novel calixpyrrole-based compounds with potent anticancer and antibacterial activities, which could have the way for the development of new therapeutics with improved efficacy and reduced toxicity.

show abstract

“…[1,2] In biomedicine, gA not only serves as antibiotics against gram-positive bacteria but also functions as therapeutic agents for cancer. [3][4][5][6][7][8][9][10][11] Composed of 15 alternating L-and D-amino acids, gA can form either a single-stranded helical dimer in a head-to-head manner or a double-stranded intertwined helix in model membrane, [2,12] depending on the property of the solvent in which gA is dissolved before incorporated into the lipid bilayer. [13,14] The single-stranded gA dimer with a larger radius can transport monovalent cations such as potassium ions (K + ) and sodium ions (Na + ) whereas the double-stranded one is considered a non-channel conformation.…”

Section: Introductionmentioning

confidence: 99%

Cholesterol-induced deformation of the gramicidin-A channel inhibiting potassium ion binding and transport

Xiao 肖,

Cao 曹,

Zhu 朱

et al. 2024

Chinese Phys. B

View full text Add to dashboard Cite

Gramicidin A (gA) is a kind of antibiotic peptide produced by Bacillus brevis and it can dimerize across lipid bilayers to form a monovalent cation channel. In this work, we investigate the impact of cholesterol in the lipid bilayer on the binding of potassium ions with gA channel and the transport of the ions across the channel. The results indicate that cholesterol can significantly influence the conformational stability of the gA channel and cause the channel deformation which inhibits the potassium ion binding with the channel and transport across the channel. The work provides some molecular insights into understanding the influence of lipids on the activity of gA channel in both model membranes and plasma membranes of intact cells.

show abstract

Ion transporters: emerging agents for anticancer therapy

Cited by 30 publications

References 85 publications

Non‐Covalently Stapled H⁺/Cl⁻ Ion Channels Activatable by Visible Light for Targeted Anticancer Therapy

Non‐Covalently Stapled H⁺/Cl⁻ Ion Channels Activatable by Visible Light for Targeted Anticancer Therapy

Exploring the Expanding Frontiers: The Promising Role of Supramolecules in Advancing Cancer and Infectious Disease Therapy

Cholesterol-induced deformation of the gramicidin-A channel inhibiting potassium ion binding and transport

Contact Info

Product

Resources

About

Ion transporters: emerging agents for anticancer therapy

Cited by 30 publications

References 85 publications

Non‐Covalently Stapled H+/Cl− Ion Channels Activatable by Visible Light for Targeted Anticancer Therapy

Non‐Covalently Stapled H+/Cl− Ion Channels Activatable by Visible Light for Targeted Anticancer Therapy

Exploring the Expanding Frontiers: The Promising Role of Supramolecules in Advancing Cancer and Infectious Disease Therapy

Cholesterol-induced deformation of the gramicidin-A channel inhibiting potassium ion binding and transport

Contact Info

Product

Resources

About

Non‐Covalently Stapled H⁺/Cl⁻ Ion Channels Activatable by Visible Light for Targeted Anticancer Therapy

Non‐Covalently Stapled H⁺/Cl⁻ Ion Channels Activatable by Visible Light for Targeted Anticancer Therapy