Ionic control of sleep and wakefulness

Landolt, Hans‐Peter; Holst, Sebastian C.

doi:10.1126/science.aaf8178

Cited by 8 publications

(5 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Here, the results of [84,97] provide encouraging help, according to which the ionic composition of interstitial fluid changes significantly during sleep, as expected. More importantly, when an artificial "sleepy" intercellular fluid is applied, the brain tissues locally go into a state physiologically similar to sleep [84].…”

Section: Ngvu As Sleep Unitsupporting

confidence: 78%

Mechanisms of Activation of Brain’s Drainage during Sleep: The Nightlife of Astrocytes

Postnov,

Semyachkina-Glushkovskaya,

Litvinenko

et al. 2023

Cells

View full text Add to dashboard Cite

The study of functions, mechanisms of generation, and pathways of movement of cerebral fluids has a long history, but the last decade has been especially productive. The proposed glymphatic hypothesis, which suggests a mechanism of the brain waste removal system (BWRS), caused an active discussion on both the criticism of some of the perspectives and our intensive study of new experimental facts. It was especially found that the intensity of the metabolite clearance changes significantly during the transition between sleep and wakefulness. Interestingly, at the cellular level, a number of aspects of this problem have been focused on, such as astrocytes–glial cells, which, over the past two decades, have been recognized as equal partners of neurons and perform many important functions. In particular, an important role was assigned to astrocytes within the framework of the glymphatic hypothesis. In this review, we return to the “astrocytocentric” view of the BWRS function and the explanation of its activation during sleep from the viewpoint of new findings over the last decade. Our main conclusion is that the BWRS’s action may be analyzed both at the systemic (whole-brain) and at the local (cellular) level. The local level means here that the neuro-glial-vascular unit can also be regarded as the smallest functional unit of sleep, and therefore, the smallest functional unit of the BWRS.

show abstract

Section: Ngvu As Sleep Unitsupporting

confidence: 78%

Mechanisms of Activation of Brain’s Drainage during Sleep: The Nightlife of Astrocytes

Postnov,

Semyachkina-Glushkovskaya,

Litvinenko

et al. 2023

Cells

View full text Add to dashboard Cite

show abstract

“…Such active penetration into the “atomic” details of ionic reactions leads to uprising of new cytological areas, for example, nanophysiology . The importance of ionic interactions in solutions has been highlighted in a number of recent chemical and biological problems. ,,− …”

Section: Introductionmentioning

confidence: 99%

Biological Activity of Ionic Liquids and Their Application in Pharmaceutics and Medicine

2017

View full text Add to dashboard Cite

Ionic liquids are remarkable chemical compounds, which find applications in many areas of modern science. Because of their highly tunable nature and exceptional properties, ionic liquids have become essential players in the fields of synthesis and catalysis, extraction, electrochemistry, analytics, biotechnology, etc. Apart from physical and chemical features of ionic liquids, their high biological activity has been attracting significant attention from biochemists, ecologists, and medical scientists. This Review is dedicated to biological activities of ionic liquids, with a special emphasis on their potential employment in pharmaceutics and medicine. The accumulated data on the biological activity of ionic liquids, including their antimicrobial and cytotoxic properties, are discussed in view of possible applications in drug synthesis and drug delivery systems. Dedicated attention is given to a novel active pharmaceutical ingredient-ionic liquid (API-IL) concept, which suggests using traditional drugs in the form of ionic liquid species. The main aim of this Review is to attract a broad audience of chemical, biological, and medical scientists to study advantages of ionic liquid pharmaceutics. Overall, the discussed data highlight the importance of the research direction defined as "Ioliomics", studies of ions in liquids in modern chemistry, biology, and medicine.

show abstract

“…The underpinnings of sleep disorders following cerebral ischemia are profoundly associated with ion interference regulation [97]. Specifically, cerebral ischemia may disrupt ion channel functions and ion equilibriums, thus perturbing sleep regulation processes [98][99][100].…”

Section: Ionsmentioning

confidence: 99%

“…Reports indicated that the activation of the G protein-gated inward rectifier K + channel (GIRK) can foster NREM sleep and solidify it [102]. By examining cerebrospinal fluid in healthy individuals during sleep, wakefulness and sleep deprivation, a study found a significant decrease in K + concentrations in sleep and sleep-deprived states compared with wakefulness [97]. Concurrently, GIRK governs the circadian excitatory rhythm of brain neurons, with the regulatory process hinging on alterations in extracellular K + concentration [103].…”

Section: Ionsmentioning

confidence: 99%

Deciphering Post-Stroke Sleep Disorders: Unveiling Neurological Mechanisms in the Realm of Brain Science

Chen,

Wang,

Ban

et al. 2024

Brain Sciences

View full text Add to dashboard Cite

Sleep disorders are the most widespread mental disorders after stroke and hurt survivors’ functional prognosis, response to restoration, and quality of life. This review will address an overview of the progress of research on the biological mechanisms associated with stroke-complicating sleep disorders. Extensive research has investigated the negative impact of stroke on sleep. However, a bidirectional association between sleep disorders and stroke exists; while stroke elevates the risk of sleep disorders, these disorders also independently contribute as a risk factor for stroke. This review aims to elucidate the mechanisms of stroke-induced sleep disorders. Possible influences were examined, including functional changes in brain regions, cerebrovascular hemodynamics, neurological deficits, sleep ion regulation, neurotransmitters, and inflammation. The results provide valuable insights into the mechanisms of stroke complicating sleep disorders.

show abstract

Ionic control of sleep and wakefulness

Cited by 8 publications

References 10 publications

Mechanisms of Activation of Brain’s Drainage during Sleep: The Nightlife of Astrocytes

Mechanisms of Activation of Brain’s Drainage during Sleep: The Nightlife of Astrocytes

Biological Activity of Ionic Liquids and Their Application in Pharmaceutics and Medicine

Deciphering Post-Stroke Sleep Disorders: Unveiling Neurological Mechanisms in the Realm of Brain Science

Contact Info

Product

Resources

About