Ionic current changes underlying action potential repolarization responses to physiological pacing and adrenergic stimulation in adult rat ventricular myocytes

Abstract

This study aimed to simulate ventricular responses to elevations in myocyte pacing and adrenergic stimulation using a novel electrophysiological rat model and investigate ion channel responses underlying action potential (AP) modulations.Peak ion currents and AP repolarization to 50% and 90% of full repolarization (APD 50-90 ) were recorded during simulations at 1-10 Hz pacing under control