Ionic currents underlying different patterns of electrical activity in working cardiac myocytes of mammals and non-mammalian vertebrates

Abramochkin, Denis V.; Филатова, Т. С.; Pustovit, Ksenia B.; Voronina, Y.; Kuzmin, Vladislav S.; Vornanen, Matti

doi:10.1016/j.cbpa.2022.111204

Cited by 16 publications

(3 citation statements)

References 198 publications

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“…), I CaL density measured in bird studies is consistently greater than that reported for ectotherms (e.g. fish [83]; turtle [29]; lizard [30], and see recent comparative review [49]). The high-density I CaL also corresponds well with reports of a large complement of LTCCs in the bird sarcolemma assessed with radio-ligand dihydropyridine-binding [31].…”

Section: Functional Studies Of Ca2+ Flux In the Bird Cardiomyocytementioning

confidence: 94%

Section: Myocyte Morphology Architecture and Excitation-contraction C...mentioning

confidence: 99%

“…rabbit [47]), the quail [32] and other bird cardiomyocytes [36]. Indeed, a recent comparative study of cardiomyocyte ionic conductance across vertebrates shows bird ventricular myocytes have larger current densities than mammals when measured under similar conditions [49]. In another comparative study, ventricular action potential waveform across mammals of different sizes/heart rates showed I Ca amplitude increased with increased body size.…”

Section: Myocyte Morphology Architecture and Excitation–contraction C...mentioning

confidence: 99%

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Avian cardiomyocyte architecture and what it reveals about the evolution of the vertebrate heart

Shiels

2022

Phil. Trans. R. Soc. B

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Bird cardiomyocytes are long, thin and lack transverse (t)-tubules, which is akin to the cardiomyocyte morphology of ectothermic non-avian reptiles, who are typified by low maximum heart rates and low pressure development. However, birds can achieve greater contractile rates and developed pressures than mammals, whose wide cardiomyocytes contain a dense t-tubular network allowing for uniform excitation–contraction coupling and strong contractile force. To address this apparent paradox, this paper functionally links recent electrophysiological studies on bird cardiomyocytes with decades of ultrastructure measurements. It shows that it is the strong transsarcolemmal Ca 2+ influx via the L-type Ca 2+ current ( I CaL ) and the high gain of Ca 2+ -induced Ca 2+ release from the sarcoplasmic reticulum (SR), coupled with an internal SR Ca 2+ release relay system, that facilitates the strong fast contractions in the long thin bird cardiomyocytes, without the need for t-tubules. The maintenance of an elongated myocyte morphology following the post-hatch transition from ectothermy to endothermy in birds is discussed in relation to cardiac load, myocyte ploidy, and cardiac regeneration potential in adult cardiomyocytes. Overall, the paper shows how little we know about cellular Ca 2+ dynamics in the bird heart and suggests how increased research efforts in this area would provide vital information in our quest to understand the role of myocyte architecture in the evolution of the vertebrate heart. This article is part of the theme issue ‘The cardiomyocyte: new revelations on the interplay between architecture and function in growth, health, and disease’. Please see glossary at the end of the paper for definitions of specialized terms.

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Section: Functional Studies Of Ca2+ Flux In the Bird Cardiomyocytementioning

confidence: 94%

Section: Myocyte Morphology Architecture and Excitation-contraction C...mentioning

confidence: 99%

Section: Myocyte Morphology Architecture and Excitation–contraction C...mentioning

confidence: 99%

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Avian cardiomyocyte architecture and what it reveals about the evolution of the vertebrate heart

Shiels

2022

Phil. Trans. R. Soc. B

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Electrical excitation, action potential and impulse conduction

Vornanen

Badr

Haverinen

2024

Encyclopedia of Fish Physiology

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High temperature and hyperkalemia increase vulnerability of navaga cod (Eleginus nawaga) cardiomyocytes to the ecotoxicant 3-methyl-phenanthrene

Abramochkin,

Shamshura,

Dzhumaniiazova

et al. 2025

Comparative Biochemistry and Physiology Part A: Molecular &

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Ionic currents underlying different patterns of electrical activity in working cardiac myocytes of mammals and non-mammalian vertebrates

Cited by 16 publications

References 198 publications

Avian cardiomyocyte architecture and what it reveals about the evolution of the vertebrate heart

Avian cardiomyocyte architecture and what it reveals about the evolution of the vertebrate heart

Electrical excitation, action potential and impulse conduction

High temperature and hyperkalemia increase vulnerability of navaga cod (Eleginus nawaga) cardiomyocytes to the ecotoxicant 3-methyl-phenanthrene

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