Ionic High-Osmolar Contrast Medium Causes Oxidant Stress in Kidney Tissue: Partial Protective Role of Ascorbic Acid

Çetin, Meltem; Devrım, Erdinç; Kılıçoğlu, Sibel Serin; Ergüder, Berrin İmge; Namuslu, Mehmet; Çetin, Recep; Durak, İlker

doi:10.1080/08860220802064739

Cited by 25 publications

(23 citation statements)

References 24 publications

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“…Those findings that address the pleiotropic effects of paricalcitol and our own findings suggest that paricalcitol may well have benefits in the chronic as well as acute situations. Cetin et al demonstrated that ionic high-osmolar contrast medium administration, either alone or together with antecedent cisplatin treatment, leads to accelerated oxidative reactions in rat kidney tissues [20]. Their findings suggest that ascorbic acid supplementation might prevent contrastinduced explosion of renal MDA levels and protect the kidney against oxidant stress.…”

Section: Discussionmentioning

confidence: 98%

“…MDA and TBARS are end products of lipid peroxidation of membrane polyunsaturated fatty acids by free radicals and are indicators of oxidative damage. Administration of contrast agent induces an increase of renal tissue and serum MDA levels and renal tissue TBARS levels on experimental CIN models [20][21][22]. To the best of our knowledge, this is the first study to examine the effects of paricalcitol on serum and renal tissue MDA, and TBARS levels after contrast exposure.…”

Section: Discussionmentioning

confidence: 99%

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Antioxidant and renoprotective effects of paricalcitol on experimental contrast-induced nephropathy model

Arı¹,

Kedrah²,

Alahdab³

et al. 2012

The British Journal of Radiology

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Objectives: The aim of the study was to assess the effect of paricalcitol on the experimental contrast-induced nephropathy (CIN) model. We hypothesised that paricalcitol may prevent CIN. Methods: 32 Wistar albino rats were divided into four groups (n58 each): control group, paricalcitol group, CIN group and paricalcitol plus CIN group. Paricalcitol (0.4 mg kg -1 day -1 ) was given intraperitoneally for 5 consecutive days prior to induction of CIN. CIN was induced at day 4 by intravenous injection of indometacin (10 mg kg -1 ), Nv-nitro-L-arginine methyl ester (L-NAME, 10 mg kg -1 ) and meglumine amidotrizoate (6 ml kg -1 ). Renal function parameters, oxidative stress biomarkers, histopathological findings and vascular endothelial growth factor (VEGF) immunoexpression were evaluated. Results: The paricalcitol plus CIN group had lower mean serum creatinine levels (p50.034) as well as higher creatinine clearance (p50.042) than the CIN group. Serum malondialdehyde and kidney thiobarbituric acid-reacting substances levels were significantly lower in the paricalcitol plus CIN group than in the CIN group (p50.024 and p50.042, respectively). The mean scores of tubular necrosis (p50.024), proteinaceous casts (p50.038), medullary congestion (p50.035) and VEGF immunoexpression (p50.018) in the paricalcitol plus CIN group were also significantly lower. Conclusion: This study demonstrates the protective effect of paricalcitol in the prevention of CIN in an experimental model.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Antioxidant and renoprotective effects of paricalcitol on experimental contrast-induced nephropathy model

Arı¹,

Kedrah²,

Alahdab³

et al. 2012

The British Journal of Radiology

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“…Contrast agents are known to be the major problem with regard to nephrotoxicity (Cetin et al, 2008). However, their effects on other organs are not known yet.…”

Section: Discussionmentioning

confidence: 99%

High osmolar contrast medium causes mild oxidation in liver, bladder, and ovary tissues from rats: vitamin C has protective role

et al. 2009

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High osmolar contrast medium causes mild oxidation in liver, bladder, and ovary tissues from rats: vitamin C has protective roleAbstract The purpose of this study was to investigate effects of ionic highosmolar contrast medium on oxidative metabolism in liver, urinary bladder, and ovary tissues and to obtain information about possible protective effects of vitamin C. Twenty-one female rats, 14 weeks old, were used in this study. They were divided into three groups of seven rats: Sham (group I), contrast (group II), contrast ? vitamin C (group III). Vitamin C was given orally to the animals in group III during the study period. On the fifth day, contrast medium was given via intravenous infusion as a single dose to the animals in groups II and III. On the sixth day of the study, the animals were killed with anesthesia by ketamine hydrochloride. Then, their liver, bladder, and ovary tissues were removed to measure analyses parameters. Our results suggested that contrast medium led to some increases in malondialdehyde levels in the liver, bladder, and ovary tissues and that vitamin C prevented these increases in the tissues. Nitric oxide level also was found to increase in the contrast-treated animals and vitamin C prevented this increase in the liver tissue. MEDICINAL CHEMISTRY RESEARCHIonic high-osmolar contrast medium leads to weak oxidant stress in rat liver, bladder, and ovary tissues, and vitamin C prevents this oxidant stress.

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“…However, there are several differences between the two studies in dosage used and the route of administration of ascorbic acid, severity of renal insufficiency, the size of study group, and so forth. The studies following Spargias et al to test the effects of ascorbic acid on CIN did not obtain as many beneficial results as their study (17,18). Additionally, one study regarding comparisons between the effects of N-acetylcysteine and ascorbic acid on preventing CIN suggests that N-acetylcysteine is more beneficial than ascorbic acid (19).…”

mentioning

confidence: 98%

Risk Assessment and Prevention of Contrast-Induced Nephropathy in Patients Undergoing Coronary Angiography

Okumura

Sone

2012

Intern. Med.

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Ionic High-Osmolar Contrast Medium Causes Oxidant Stress in Kidney Tissue: Partial Protective Role of Ascorbic Acid

Cited by 25 publications

References 24 publications

Antioxidant and renoprotective effects of paricalcitol on experimental contrast-induced nephropathy model

Antioxidant and renoprotective effects of paricalcitol on experimental contrast-induced nephropathy model

High osmolar contrast medium causes mild oxidation in liver, bladder, and ovary tissues from rats: vitamin C has protective role

Risk Assessment and Prevention of Contrast-Induced Nephropathy in Patients Undergoing Coronary Angiography

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