Ionic liquid-caged nucleic acids enable active folding-based molecular recognition with hydrolysis resistance
Byunghwa Kang,
Soyeon V Park,
Seung Soo Oh
Abstract:Beyond storage and transmission of genetic information in cellular life, nucleic acids can perform diverse interesting functions, including specific target recognition and biochemical reaction acceleration; the versatile biopolymers, however, are acutely vulnerable to hydrolysis-driven degradation. Here, we demonstrate that the cage effect of choline dihydrogen phosphate permits active folding of nucleic acids like water, but prevents their phosphodiester hydrolysis unlike water. The choline-based ionic liquid… Show more
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