Ionic Liquid Crystals Modifier for Selective Determination of Terazosin Antihypertensive Drug in Presence of Common Interference Compounds

Atta, Nada F.; BinSabt, Mohammad H.; Hassan, Samar H.; Galal, Ahmed M.

doi:10.3390/cryst7010027

Cited by 15 publications

(16 citation statements)

References 80 publications

(48 reference statements)

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“…The modest viscosity and decent high conductivity of the MCNT-BMH-SDS/CPE enabled its delivery into the spaces among the past flakes improving its dispersal with the modified graphite paste. 42,43 The breakthrough of the exceedingly conductive ionic liquids crystal (ILC) among the graphite flakes caused in a well-ordered films influencing on paste conductivity because of the solid formal assembly of ILC with its molecular orientation. In case of the occurrence of SDS, squishy films of SDS were collected at surface of electrode (Fig.…”

Section: Electrodes Surface Morphologymentioning

confidence: 99%

Highly Sensitive Voltammetric Sensor Using Carbon Nanotube and an Ionic Liquid Composite Electrode for Xylazine Hydrochloride

El-Shal

Hendawy

2018

ANAL. SCI.

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Electrochemical techniques were used for estimating xylazine HCl (XLZ) in bulk powder, medicinal manufacturing and human serum. Electro-oxidation of XLZ at carbon multiwalled nanotube (MWCNT), 1-n-butyl-3-methylpyridinium hexafluorophosphate ion crystal (BMH) and sodium dodecyl sulfate (SDS) MWCNT-BMH-SDS electrode in 0.04 M Britton-Robinson buffer (BR) with pH 7.0, was studied in numerous buffer structures and at different pH values. The experimentation and instrumental parameters to assessable commitment of XLZ had been optimized, and a detection limit was observed as 4.80 nM. The precision and accuracy for the recognized method was tested by retrieval studies with good repeatability and reproducibility of the estimated method. The projected method was practiced successfully to the dosage form and spiked serum.

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Section: Electrodes Surface Morphologymentioning

confidence: 99%

Highly Sensitive Voltammetric Sensor Using Carbon Nanotube and an Ionic Liquid Composite Electrode for Xylazine Hydrochloride

El-Shal

Hendawy

2018

ANAL. SCI.

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“…Electrochemical impedance spectroscopy can successfully be employed to understand the effect of stepwise modification of the proposed sensor. For instance, the faradaic resistance and capacitive changes can be followed accordingly at the interface .…”

Section: Resultsmentioning

confidence: 99%

“…It is necessary to study the anti‐interference ability of the proposed sensor toward DOPAC determination in the presence of common interferents in the biological fluids and drugs. Terazosin hydrochloride (TZ) is used to treat high blood pressure . Morphine (MO) is one of the severe pain relief drugs .…”

Section: Resultsmentioning

confidence: 99%

Fabrication of β‐Cyclodextrin/Glycine/Carbon Nanotubes Electrochemical Neurotransmitters Sensor – Application in Ultra‐sensitive Determination of DOPAC in Human Serum

et al. 2018

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In this work, an electrochemical sensor was constructed by applying two successive thin layers of glycine‐carbon nanotubes mixture and β‐cyclodextrin (CNTs‐Gly)/CD over glassy carbon electrode surface for some neurotransmitters determination. A host‐guest interaction between CD and neurotransmitters molecules is expected and resulted in enhanced sensitivity, selectivity and stability of sensor response. Other components of the sensor are crucial for the unique electrochemical response. Carbon nanotubes allowed large surface area for glycine distribution that provided hydrogen bonding to CD moieties and contributed to facilitated charge transfer. It was possible to determine 3,4‐dihydroxy phenyl acetic acid (DOPAC) in the linear range of 0.1 μmol L−1 to 80 μmol L−1 with detection limit of 9.40 nmol L−1, quantification limit of 31.5 nmol L−1 and sensitivity of 4.16 μA/μmol L−1. The proposed sensor was applied in synthetic cerebrospinal fluids samples using random standard addition method. Also, the proposed sensor was used to determine DOPAC in presence of common interferences and acceptable recovery results were achieved for its analysis in real blood serum. Figures of merit for (CNTs‐Gly)/CD composite in terms of precision, robustness, repeatability and reproducibility were reported.

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“…Also, the abundance of negative π‐electrons on CNTs surfaces had a great affinity for the positively charged ILCs . In previous work, we demonstrated that different ionic liquid crystals can be used as excellent active modifiers in the determination of several organic compounds .…”

Section: Introductionmentioning

confidence: 94%

Electrochemical Determination of Neurotransmitters at Crown Ether Modified Carbon Nanotube Composite: Application for Sub‐nano‐sensing of Serotonin in Human Serum

2018

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We propose an electrochemical sensor based on applying two successive thin layers from a mixture of multiwalled carbon nanotubes‐ionic liquid crystal and crown ether at glassy carbon electrode surface (GC/(CNTs‐ILC)/Crown). The sensor was used for sensitive determination of neurotransmitters based on effective synergism between its components. The compact conducting surface of (CNTs‐ILC) with large surface area allowed the assembling of stable host‐guest inclusion complexes between crown ethers and neurotransmitters. The GC/(CNTs‐ILC)/Crown exhibited excellent electro‐catalytic activity toward the determination of serotonin (ST) in a wide linear dynamic range: 0.005 μmol L−1 to 100 μmol L−1. In the concentration range 0.005 μmol L−1 to 1 μmol L−1, the detection limit is 2.03×10−10 mol L−1 and quantification limit is 6.78×10−10 mol L−1 with correlation coefficient 0.999. The sensor was successfully applied for ST detection in human serum samples with satisfied recovery results. The sensor showed excellent analytical performance for the determination of ST in terms of low detection limit, good sensitivity and reproducibility. Furthermore excellent anti‐interference ability and simultaneous determination of ST in presence of other compounds as ascorbic acid, dopamine and antidepressant drug were achieved.

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Ionic Liquid Crystals Modifier for Selective Determination of Terazosin Antihypertensive Drug in Presence of Common Interference Compounds

Cited by 15 publications

References 80 publications

Highly Sensitive Voltammetric Sensor Using Carbon Nanotube and an Ionic Liquid Composite Electrode for Xylazine Hydrochloride

Highly Sensitive Voltammetric Sensor Using Carbon Nanotube and an Ionic Liquid Composite Electrode for Xylazine Hydrochloride

Fabrication of β‐Cyclodextrin/Glycine/Carbon Nanotubes Electrochemical Neurotransmitters Sensor – Application in Ultra‐sensitive Determination of DOPAC in Human Serum

Electrochemical Determination of Neurotransmitters at Crown Ether Modified Carbon Nanotube Composite: Application for Sub‐nano‐sensing of Serotonin in Human Serum

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