Ionic Liquid–Mediated, One-Pot Synthesis for 4-Thiazolidinones

One-pot rapid synthesis of thiazole-substituted pyrazolyl-4-thiazolidinones mediated by diisopropylethylammonium acetate

“…Aromatic aldehydes with several functionalities such as Cl, OH, CH 3 , OCH 3 and NO 2 were found to be compatible under the optimised reaction condition. Aldehydes having no substituent on phenyl ring reacted smoothly, and the products were obtained in excellent yields ranging from 88 to 93 % ( The melting points of these products prepared in this work are in good agreement with those reported in literature [24,25,28] One-pot rapid synthesis of pyrazolyl-4-thiazolidinones and other physical data found to be in good agreement with those reported in literature [24,26,28]. Encouraged by this success and in continuation of our endeavour towards synthesis of bioactive heterocycles, here we applied the above same strategy for one-pot cyclocondensation of heteryl aldehydes to obtain the thiazolidinones (Scheme 2).…”

“…While conducting multicomponent cyclocondensation leading to 4-thiazolidinones and to accelerate the rate of the cyclocondensation, in our reports we used alternative media such as PEG-400 [23] and N-methylpyridinium tosylate (ionic liquid) [24]. We even reported the catalytic role of heterogeneous catalysts such as silica chloride [25] and biocatalyst, baker's yeast [26] in accelerating the cyclocondensation.…”

Synthesis and Antimicrobial Activity of N-[2-(aryl/substituted aryl)-4-oxo-1,3-thiazolidin-3-yl]pyridine-4-carboxamide

“…The microwave method required shorter reaction times (6-9 mins for completion of reaction) with improved yields (87.5-98.76%) as compared to the reported conventional methods. The reported microwave methods were carried out in the presence of different organic solvents [26][27][28][29] as compared to the use of water as a solvent in our reported method. The synthesized Schiff's base intermediates were characterized by the presence of strong band at 1531-1620 cm -1 for the N=C imino group.…”

The First Solvent‐Free, Microwave‐Accelerated, Three‐Component Synthesis of Thiazolidin‐4‐ones via One‐Pot Tandem Staudinger/aza‐Wittig Reaction

“…Elemental analyses were performed and were found to be in agreement, that is, within ±0.4% of the calculated values. Compounds 4a , ( 4b , 4c , 4d ) , 4e , ( 4k , 4l ) [ 12a ] , ( 4o , 4p , 4q ) , and ( 4r , 4s , 4t ) are known, and their 1 H and 13 C NMR spectra are identical to the reported values.…”