Ionic liquids as an alternative to formalin in histopathological diagnosis

Pernak, Agnieszka; Iwanik, Katarzyna; Majewski, Przemysław; Grzymisławski, Marian; Pernak, J.

doi:10.1016/j.acthis.2005.02.003

Cited by 27 publications

(20 citation statements)

References 19 publications

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“…[31] Total coefficient Deterrent activity 200-151 very good 150-101 good 100-51 medium 50-0 weak À salts for tissue (animal muscle-beef) preservation by a previously described procedure. [5,6] À salt 4 f fixed the tissue but did not alter its structure, also preserving its elasticity and color. www.chemeurj.org…”

Section: Indicate That [Ace]mentioning

confidence: 96%

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Choline‐Derivative‐Based Ionic Liquids

Pernak

Syguda

Mirska

et al. 2007

Chemistry A European J

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181

149

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A total of sixty-three choline derivative-based ionic liquids in the forms of chlorides, acesulfamates, and bis(trifluoromethylsulfonyl)imides have been prepared and their physical properties (density, viscosity, solubility, and thermal stability) have been determined. Thirteen of these salts are known chlorides: precursors to the 26 water-soluble acesulfamates, 12 acesulfamates only partially miscible with water, and 12 water-insoluble imides. The crystal structures for two of the chloride salts-(2-hydroxyethyl)dimethylundecyloxymethylammonium chloride and cyclododecyloxymethyl(2-hydroxyethyl)dimethylammonium chloride-were determined. The antimicrobial (cocci, rods, and fungi) activities of the new hydrophilic acesulfamate-based ILs were measured and 12 were found to be active. The alkoxymethyl(2-hydroxyethyl)dimethylammonium acesulfamates have been shown to be insect feeding deterrents and thus open up a new generation of synthetic deterrents based on ionic liquids. The alkoxymethyl(2-decanoyloxyethyl)dimethylammonium bis(trifluoromethylsulfonyl)imides have also been shown to act as fixatives for soft tissues and can furthermore be used as substitutes for formalin and also preservatives for blood.

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Section: Indicate That [Ace]mentioning

confidence: 96%

“…[4] ILs have even been used as tools in embalming and tissue preservation in histopathological diagnosis. [5,6] Quaternary ammonium salts (quats), or inverted soaps, are well known cationic surfactants. They each contain at least one or two long (eight or more carbon atoms) alkyl chains and retain their cationic character at any pH.…”

Section: Introductionmentioning

confidence: 99%

Choline‐Derivative‐Based Ionic Liquids

Pernak

Syguda

Mirska

et al. 2007

Chemistry A European J

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181

149

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“…Ionic liquids have been used as environmentally benign solvents for a number of processes, such as separations, reactions, homogeneous twophase catalysis, and polymerizations [11]. These fascinating liquids have extended their importance not only to chemistry, but across a broad scientific spectrum, including tissue preservation in histopathological procedures, eliminating the requirement of formalin [12], or in rocket science [13]. Since the pioneering work by Rogers group [14], several attempts have been made to use ionic liquids as alternatives to traditional organic diluents in solvent extraction of organic molecules and metal ions.…”

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confidence: 99%

Ionic Liquids for the Production of Insecticidal and Microbicidal Extracts of the Fungus Cantharellus cibarius

Cieniecka‐Rosłonkiewicz

Sas

Przybysz

et al. 2007

Chemistry & Biodiversity

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Different ionic liquids were used as solvents for the effective extraction of the active metabolites of the fruit bodies of C. cibarius. The type of ionic liquid was found to play a significant role in this process. We found that the protic ionic liquid 1-[(nonyloxy)methyl]-1H-imidazol-3-ium salicylate (6) is a most-efficient extracting agent, being superior to classical solvents such as AcOEt or hexane. The obtained extracts generally revealed high insecticidal activities against both house fly and cockroach, with similar potencies as the standard pesticides bromfenvinphos or alphacypermethrin, as well as significant activities against bacteria, yeast, and moulds. Notably, the cidal activities against plant-pathogenic bacteria were stronger than against human bacterial strains.

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“…[36][37][38] Along with electrochemical applications, ILs have gained momentum in bio applications. Recent work in the area include ILs as biocatalytic reactions [27,39] , biosensors [40] , protein stabilization [41] and biopreservation [42] . They have been proposed as unique solvents for biomolecules such as proteins / enzymes because of their unusual solvation characteristics.…”

Section: Ionogels: a Diverse Materials For Sensing Platformsmentioning

confidence: 99%

Wearable electrochemical sensors for monitoring performance athletes

Fraser¹,

Curto²,

Coyle³

et al. 2011

SPIE Proceedings

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Nowadays, wearable sensors such as heart rate monitors and pedometers are in common use. The use of wearable systems such as these for personalized exercise regimes for health and rehabilitation is particularly interesting. In particular, the true potential of wearable chemical sensors, which for the real-time ambulatory monitoring of bodily fluids such as tears, sweat, urine and blood has not been realized. Here we present a brief introduction into the fields of ionogels and organic electrochemical transistors, and in particular, the concept of an OECT transistor incorporated into a sticking-plaster, along with a printable "ionogel" to provide a wearable biosensor platform.

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Ionic liquids as an alternative to formalin in histopathological diagnosis

Cited by 27 publications

References 19 publications

Choline‐Derivative‐Based Ionic Liquids

Choline‐Derivative‐Based Ionic Liquids

Ionic Liquids for the Production of Insecticidal and Microbicidal Extracts of the Fungus Cantharellus cibarius

Wearable electrochemical sensors for monitoring performance athletes

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