Ionic Liquids from Biocompatibility and Electrochemical Aspects toward Applying in Biosensing Devices

Ghorbanizamani, Faezeh; Timur, Suna

doi:10.1021/acs.analchem.7b03596

Cited by 39 publications

(26 citation statements)

References 144 publications

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“…Ionic liquids (ILs) are organic salts composed of an organic cation and an organic or an inorganic anion which are liquid below 100 C. The physico-chemical properties of these neoteric solvents (e.g., negligible vapor pressure, wide electrochemical window, high thermal stability, low ammability) [1][2][3] and the possibility to tweak them by changing the constituent ions 4 allowed their use in different elds. ILs have been studied and exploited for instance in the dissolution, fractionation and functionalization of biomasses, [5][6][7][8] in organic synthesis, 9,10 in analytical chemistry, 11 in electrochemistry 12,13 and, more recently, in biological and pharmaceutical applications. 14 Dicationic ionic liquids (DILs) are a subclass of ILs which are characterized by two cationic head groups linked to one another by means of a spacer.…”

Section: Introductionmentioning

confidence: 99%

An insight into the intermolecular vibrational modes of dicationic ionic liquids through far-infrared spectroscopy and DFT calculations

et al. 2019

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Section: Introductionmentioning

confidence: 99%

An insight into the intermolecular vibrational modes of dicationic ionic liquids through far-infrared spectroscopy and DFT calculations

et al. 2019

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“…Ionic liquids (ILs), with its intriguing properties such as excellent ionic conductivity; wide solubility range; zero vapor pressure; high chemical, thermal, and redox stability; and excellent biocompatibility, offer a plethora of design combinations by modifying the properties of both organic cations and inorganic anions independently. [27][28][29] This modification or functionalization of ILs (known as "task-specific ionic liquids-TSILs") has enabled versatile physicochemical properties, which are suitable for specific applications. Hitherto, aldehyde functionalized ILs (CHO-IL) have been used frequently for the fabrication of ultrasensitive sensors and biosensors.…”

Section: Introductionmentioning

confidence: 99%

An Electrodeposited MXene‐Ti₃C₂T_x Nanosheets Functionalized by Task‐Specific Ionic Liquid for Simultaneous and Multiplexed Detection of Bladder Cancer Biomarkers

Sharifuzzaman

Barman

Zahed

et al. 2020

Small

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MXenes (with chemical formula M n+1 X n T x , where M = transition metals such as Ti, Sc, V, Nb, Mo, and Cr; X = C and/or N; T x = surface functional groups, such as OH, O, and minor F; n = 1, 2, or 3) are synthesized by selectively etching Agroup sp elements (typically group III A or IV A such as Al or Ga) from layered parent ternary MAX phases (with chemical formula Mn + 1AXn, where, A = elements from groups 13 and 14, such as Al, Ga, C, and Si). [3] To date, families of MXenes comprising more than 30 members have been successfully synthesized, such as Ti 2 CT x , V 2 CT x , Mo 2 CT x , and Ti 3 C 2 T x. [3] Among them, MXene-Ti 3 C 2 T x nanosheets (MXNSs) is the most promising and wellstudied candidate owing to its optimized synthesis, high metallic conductivity, high strength, high stability, excellent catalytic properties, and hydrophilicity with various surface functionalities. [1,4,5] Owing to its versatile chemistry, MXNSs is a promising candidate in a plethora of applications, including supercapacitors, energy storage, [6,7] electronics, [8] and catalysis, [5] In addition, MXNSs have recently emerged as excellent transducing electrode material in electrochemical biosensing owing to its active inherent electrochemistry compared with other 2D nanomaterials. Hitherto, several biosensors based on MXNSs have been utilized for the detection of prostate specific antigen, [9] phenol, [10] microRNA-182, [11] glucose, [12] acetaminophen, and isoniazid. [13] In the fabrication of advanced biosensors, the most challenging issue of arranging nanomaterials into a particular position on a patterned electrode with controlled architecture, morphology, and thickness should be solved. Many chemicals, as well as physical deposition techniques, have been established to assemble 2D nanomaterials (graphene, CNT, MoS 2 , and MXene) over electrodes. Currently, the most popular approaches for assembling 2D nanomaterials onto electrodes for sensing rely on chemical deposition techniques, for example, layer-by-layer assembly, [14,15] spin coating, [16] inkjet printing, [17] spray coating, [18] vacuum filtration, [19] and Controlled deposition of 2D multilayered nanomaterials onto different electrodes to design a highly sensitive biosensing platform utilizing their active inherent electrochemistry is extremely challenging. Herein, a green, facile, and cost-effective one-pot deposition mechanism of 2D MXene-Ti 3 C 2 T x nanosheets (MXNSs) onto conductive electrodes within few minutes via electroplating (termed electroMXenition) is reported for the first time. The redox reaction in the colloidal MXNS solution under the effect of a constant applied potential generates an electric field, which drives the nanoparticles toward a specific electrode interface such that they are cathodically electroplated. A task-specific ionic liquid, that is, 4-amino-1-(4-formyl-benzyl) pyridinium bromide (AFBPB), is exploited as a multiplex host arena for the substantial immobilization of MXNSs and covalent binding of antibodies. A miniaturized, singl...

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“…RTIL is generally a combination of a large asymmetric organic cation and a small organic/inorganic anion present in a molten state. There are many reported synthetic RTILs, among which, functionalized imidazolium, pyridinium, quaternary ammonium salts can be found as popular cation choices whereas halides, tetrafluoroborate(BF 4 − ), tetrachloroaluminate (AlCl 4 − ), hexafluorophosphate (PF 6 − ), bis (perfluoromethylsulphonyl) imide/bistriflate imide (TF 2 N) and trifluoromethanesulphonate (F 3 MeSO 4 − ) are used as common anions of RTIL [7][8][9][10][11][12][13]. There is a wide array of compounds that can be synthesized to leverage the physicochemical properties of RTILs through proper selection of cationic and anionic groups.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Room-Temperature Ionic Liquids to Study the Electrochemical Activity of Nitro Compounds

Banga

Paul

Muthukumar

et al. 2020

Sensors

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Over the past few years, room-temperature ionic liquid (RTIL) has evolved as an important solvent-cum-electrolyte because of its high thermal stability and excellent electrochemical activity. Due to these unique properties, RTILs have been used as a solvent/electrolyte/mediator in many applications. There are many RTILs, which possess good conductivity as well as an optimal electrochemical window, thus enabling their application as a transducer for electrochemical sensors. Nitroaromatics are a class of organic compounds with significant industrial applications; however, due to their excess use, detection is a major concern. The electrochemical performance of a glassy carbon electrode modified with three different RTILs, [EMIM][BF4], [BMIM][BF4] and [EMIM][TF2N], has been evaluated for the sensing of two different nitroaromatic analytes: 2,6-dinitrotoluene (2,6 DNT) and ethylnitrobenzene (ENB). Three RTILs have been chosen such that they have either a common anion or cation amongst them. The sensory response has been measured using square wave voltammetry (SQWV). We found the transducing ability of [EMIM][BF4] to be superior compared to the other two RTILs. A low limit of detection (LOD) of 1 ppm has been achieved with a 95% confidence interval for both the analytes. The efficacy of varying the cationic and anionic species of RTIL to obtain a perfect combination has been thoroughly investigated in this work, which shows a novel selection process of RTILs for specific applications. Moreover, the results obtained from testing with a glassy carbon electrode (GCE) have been replicated using a miniaturized sensor platform that can be deployed easily for on-site sensing applications.

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Ionic Liquids from Biocompatibility and Electrochemical Aspects toward Applying in Biosensing Devices

Cited by 39 publications

References 144 publications

An insight into the intermolecular vibrational modes of dicationic ionic liquids through far-infrared spectroscopy and DFT calculations

An insight into the intermolecular vibrational modes of dicationic ionic liquids through far-infrared spectroscopy and DFT calculations

An Electrodeposited MXene‐Ti₃C₂T_x Nanosheets Functionalized by Task‐Specific Ionic Liquid for Simultaneous and Multiplexed Detection of Bladder Cancer Biomarkers

Characterization of Room-Temperature Ionic Liquids to Study the Electrochemical Activity of Nitro Compounds

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Ionic Liquids from Biocompatibility and Electrochemical Aspects toward Applying in Biosensing Devices

Cited by 39 publications

References 144 publications

An insight into the intermolecular vibrational modes of dicationic ionic liquids through far-infrared spectroscopy and DFT calculations

An insight into the intermolecular vibrational modes of dicationic ionic liquids through far-infrared spectroscopy and DFT calculations

An Electrodeposited MXene‐Ti3C2Tx Nanosheets Functionalized by Task‐Specific Ionic Liquid for Simultaneous and Multiplexed Detection of Bladder Cancer Biomarkers

Characterization of Room-Temperature Ionic Liquids to Study the Electrochemical Activity of Nitro Compounds

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An Electrodeposited MXene‐Ti₃C₂T_x Nanosheets Functionalized by Task‐Specific Ionic Liquid for Simultaneous and Multiplexed Detection of Bladder Cancer Biomarkers