Ionic mononuclear [Fe] and heterodinuclear [Fe,Ru] bis(diphenylphosphino)alkane complexes: Synthesis, spectroscopy, DFT structures, cytotoxicity, and biomolecular interactions

Odachowski, Matylda; Neven, Robin; Perversi, Giuditta; Romano, Dario; Slabber, Cathryn A.; Hadiji, Mouna; Honing, Maarten; Zhao, Yuan‐Di; Munro, Orde Q.; Blom, Burgert

doi:10.1016/j.jinorgbio.2023.112156

Journal of Inorganic Biochemistry

2023

DOI: 10.1016/j.jinorgbio.2023.112156

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Ionic mononuclear [Fe] and heterodinuclear [Fe,Ru] bis(diphenylphosphino)alkane complexes: Synthesis, spectroscopy, DFT structures, cytotoxicity, and biomolecular interactions

Matylda Odachowski

Robin Neven

Giuditta Perversi

et al.

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Cited by 6 publications

References 128 publications

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Anti‐Amyloid Aggregation and Anti‐Hyperglycemic Activities of Novel Ruthenium Uracil Schiff Base Compounds

Makanyane,

Mabuza,

Ngubane

et al. 2024

ChemMedChem

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The formation and characterization of new diamagnetic ruthenium uracil mono‐imine compounds: [(η6‐p‐cymene)RuII(L)Cl][BF4] (L = H2urpda = 5‐((pyridin‐2‐yl)methyleneamino)‐6‐aminouracil) for 1, urdpy = 6‐amino‐1,3‐dimethyl‐5‐((pyridin‐2‐ylmethylene)amino)uracil) for 2 or urqda = 5‐((quinolin‐2‐yl)methyleneamino)‐6‐aminouracil) for 3); cis‐[RuII(L)(bipy)2] (L = urpy = 5‐((pyridin‐2‐yl)methyleneamino)uracil) for 4 and H2dadp = 5,6‐diaminouracil for 5) are described. A paramagnetic ruthenium uracil Schiff base compound, trans‐[RuIV(L)(PPh3)Cl2] (L = H2urpda for 6) was also formed. Various physicochemical techniques were utilized to characterize the novel ruthenium compounds. Similarly, the stabilities of 1 ‐ 3 and 6 monitored in chloro‐containing and the non‐coordinating solvent, dichloromethane show that they are kinetically inert, whereas, in a high nucleophilic environment, the chloride co‐ligands of these ruthenium complexes were rapidly substituted by DMSO. In contrast, the substitution of the labile co‐ligands for these ruthenium complexes by DMSO molecules in a high chloride content was suppressed. Solution chemical reactivities of the different ruthenium complexes were rationalized by density functional theory computations. Furthermore, the binding affinities and strengths between BSA and the respective ruthenium complexes were monitored using fluorescence spectroscopy. In addition, the in vitro anti‐diabetic activities of the novel metal complexes were assessed in selected skeletal muscle and liver cell lines.

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Anti‐Amyloid Aggregation and Anti‐Hyperglycemic Activities of Novel Ruthenium Uracil Schiff Base Compounds

Makanyane,

Mabuza,

Ngubane

et al. 2024

ChemMedChem

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Homo and heteromultimetallic complexes containing a group 8 transition metal and μ-diphosphine bridging ligands involved in anticancer research: A review

Roufosse,

Serbu,

Marschner

et al. 2024

European Journal of Medicinal Chemistry

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A comparative study of novel ruthenium(III) and iron(III) complexes containing uracil; docking and biological studies

Althobaiti

Sahyon

Shanab

et al. 2023

Journal of Inorganic Biochemistry

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Ionic mononuclear [Fe] and heterodinuclear [Fe,Ru] bis(diphenylphosphino)alkane complexes: Synthesis, spectroscopy, DFT structures, cytotoxicity, and biomolecular interactions

Cited by 6 publications

References 128 publications

Anti‐Amyloid Aggregation and Anti‐Hyperglycemic Activities of Novel Ruthenium Uracil Schiff Base Compounds

Anti‐Amyloid Aggregation and Anti‐Hyperglycemic Activities of Novel Ruthenium Uracil Schiff Base Compounds

Homo and heteromultimetallic complexes containing a group 8 transition metal and μ-diphosphine bridging ligands involved in anticancer research: A review

A comparative study of novel ruthenium(III) and iron(III) complexes containing uracil; docking and biological studies

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