Ionic self‐assembly and characterization of a polysaccharide‐based polyelectrolyte complex of maleic starch half‐ester acid with chitosan

Xiao, Congming; Fang, Fang

doi:10.1002/app.29763

Cited by 20 publications

(5 citation statements)

References 18 publications

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“…For instance, a carboxylic derivative of starch, maleic starch half-ester acid (MSA), has been prepared via the esterification of starch with maleic anhydride in the presence of pyridine [58]. MSA is an anionic polyelectrolyte, consequently it can perform ionic self-assembly with chitosan in aqueous solution and forms a polysaccharide-based polyelectrolyte complex [59].…”

Section: Chemical Derivativesmentioning

confidence: 99%

Starch-based completely biodegradable polymer materials

Lu¹,

Xiao²,

Xu³

2009

Express Polym. Lett.

645

320

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Abstract. Starch is a natural polymer which possesses many unique properties and some shortcoming simultaneously. Some synthetic polymers are biodegradable and can be tailor-made easily. Therefore, by combining the individual advantages of starch and synthetic polymers, starch-based completely biodegradable polymers (SCBP) are potential for applications in biomedical and environmental fields. Therefore it received great attention and was extensively investigated. In this paper, the structure and characteristics of starch and some synthetic degradable polymers are briefly introduced. Then, the recent progress about the preparation of SCBP via physical blending and chemical modification is reviewed and discussed. At last, some examples have been presented to elucidate that SCBP are promising materials for various applications and their development is a good solution for reducing the consumption of petroleum resources and environmental problem.

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Section: Chemical Derivativesmentioning

confidence: 99%

Starch-based completely biodegradable polymer materials

Lu¹,

Xiao²,

Xu³

2009

Express Polym. Lett.

645

320

View full text Add to dashboard Cite

show abstract

“…Characterisation and evaluation of this complex indicated the driving force for self-assembly was electrostatic interactions. A pH sensitive release of 5-fluorouracil was obtained that was also dependent on the maleic starch half-ester to chitosan ratio as well as the carboxyl content of maleic starch half-ester used as starting material [ 57 ].…”

Section: Polyelectrolyte Complexes Between Chitosan and Natural Pomentioning

confidence: 99%

Chitosan Based Polyelectrolyte Complexes as Potential Carrier Materials in Drug Delivery Systems

2010

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Chitosan has been the subject of interest for its use as a polymeric drug carrier material in dosage form design due to its appealing properties such as biocompatibility, biodegradability, low toxicity and relatively low production cost from abundant natural sources. However, one drawback of using this natural polysaccharide in modified release dosage forms for oral administration is its fast dissolution rate in the stomach. Since chitosan is positively charged at low pH values (below its pKa value), it spontaneously associates with negatively charged polyions in solution to form polyelectrolyte complexes. These chitosan based polyelectrolyte complexes exhibit favourable physicochemical properties with preservation of chitosan’s biocompatible characteristics. These complexes are therefore good candidate excipient materials for the design of different types of dosage forms. It is the aim of this review to describe complexation of chitosan with selected natural and synthetic polyanions and to indicate some of the factors that influence the formation and stability of these polyelectrolyte complexes. Furthermore, recent investigations into the use of these complexes as excipients in drug delivery systems such as nano- and microparticles, beads, fibers, sponges and matrix type tablets are briefly described.

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“…These micelles with a core–corona structure provided high water solubility and protection of the antisense oligonucleotides in the micelle core . Charged BCPs or block copolyelectrolytes (BCPEs) provide various possibilities for protein/peptide delivery, due to their ability to form complexes with oppositely charged materials. − They can also be employed as solid electrolytes for energy storage, as their self-assembled structures could simultaneously facilitate ion transport and maintain structural integrity. ,, For instance, lamella-forming polystyrene- block -poly(2-vinylpyridine) (PS- b -P2VP) functionalized by methyl iodide (positively charged PS- b -P2VP) could be used as an ion-conducting film, whose electrochemical behavior highly depended on its microphase separation structure. The conductivity of the film with a connected structure was more than 4 orders of magnitude larger than that of the unconnected structure .…”

Section: Introductionmentioning

confidence: 99%

Electrostatic Control of the Three-Dimensional Confined Assembly of Charged Block Copolymers in Emulsion Droplets

et al. 2021

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Understanding the microphase separation of charged block copolymers (BCPs) is very important for the development of functional materials with tunable structures. Although the morphological behavior of charged BCPs in bulk and in solution has been explored, the three-dimensional (3D) confined self-assembly of charged BCPs is still unknown. Here, we report the confined assembly of positively charged polystyrene-block-poly(4-vinylpyridine) (PS-b-P4VP) in emulsion droplets. The fraction of charged segments can be well tailored by the quaternization of the 4VP unit with methyl iodide. A series of BCP particles, including pupa-like, onion-like, bumpy, sphere-in-sphere particles, large compound vesicles, and others, could be obtained by tuning the charge fraction and block ratio of BCPs. The introduction of charge affected the hydrophilicity and chain conformation of BCPs, leading to the change in the morphology of assemblies. Moreover, the addition of inorganic salts showed an obvious effect on the assembly of charged PS-b-P4VP, whose morphology was dependent on the hydration nature of the counterions. This work not only presents a fundamental understanding of the self-assembly of charged BCP under 3D confinement but also inspires the design and preparation of functional nanoparticles with tunable morphologies.

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Ionic self‐assembly and characterization of a polysaccharide‐based polyelectrolyte complex of maleic starch half‐ester acid with chitosan

Cited by 20 publications

References 18 publications

Starch-based completely biodegradable polymer materials

Starch-based completely biodegradable polymer materials

Chitosan Based Polyelectrolyte Complexes as Potential Carrier Materials in Drug Delivery Systems

Electrostatic Control of the Three-Dimensional Confined Assembly of Charged Block Copolymers in Emulsion Droplets

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