Ionized and total magnesium concentration in patients with severe preeclampsia‐eclampsia undergoing magnesium sulfate therapy

Aali, Bibi Shahnaz; Khazaeli, Payam; Ghasemi, Fatemeh

doi:10.1111/j.1447-0756.2007.00508.x

Cited by 30 publications

(34 citation statements)

References 21 publications

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“…Of note, the studied group did not suffer from obesity. HDMI pharmacokinetic have shown magnesium serum levels associated with smooth muscle relaxation but a need of adjustment in patients with obesity (9,10,(26)(27)(28)(29).…”

Section: Discussionmentioning

confidence: 99%

High-Dose Magnesium Sulfate Infusion for Severe Asthma in the Emergency Department

Irazuzta

Paredes

Pavlicich

et al. 2016

Pediatric Critical Care Medicine

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Section: Discussionmentioning

confidence: 99%

High-Dose Magnesium Sulfate Infusion for Severe Asthma in the Emergency Department

Irazuzta

Paredes

Pavlicich

et al. 2016

Pediatric Critical Care Medicine

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“…13 While the amount of iMg capable of producing relaxation is not completely understood, recent reports for preeclampsia describe target values of 0.9 to 1.6 mmol/L. 4,[14][15][16] The asthma literature is hesitant to target dosing that achieves decreases in reflexes for fear of inducing respiratory failure due to decreased respiratory muscle strength.…”

Section: Discussionmentioning

confidence: 99%

“…Magnesium sulfate's spasmolytic effect, when administered as a continuous infusion, has been used in patients with preeclampsia, pulmonary hypertension, brain injury, and subarachnoid hemorrhage. [4][5][6][7] In these settings, the strategy of continuous infusion produces a sustained effect by exceeding the rate of magnesium elimination by the kidney. A sustained effect may be the one desirable effect for asthma.…”

Section: Introductionmentioning

confidence: 99%

Feasibility of Short-Term Infusion of Magnesium Sulfate in Pediatric Patients With Status Asthmaticus

Irazuzta

Egelund

Wassil

et al. 2012

The Journal of Pediatric Pharmacology and Therapeutics

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OBJECTIVE This report describes the feasibility of high-dose magnesium sulfate infusion in pediatric patients with status asthmaticus. METHODS Retrospective chart review over a 3-year period of all patients younger than 18 years of age with status asthmaticus who underwent a high-dose magnesium sulfate infusion for 4 hours. All patients were breathing spontaneously but were refractory to conventional therapy. The magnesium sulfate infusion regimen was 50 mg/kg (for patients weighing .30 kg) or 75 mg/kg (for those weighing 30 kg) over a period of 30 to 45 minutes, followed by a continuous infusion of 40 mg/kg/hr for 4 hours. Information regarding vital and clinical respiratory signs, serum magnesium (SrMg), ionized magnesium (iMg), electrocardiograms, and cardiac troponin levels were retrieved. We analyzed the relationship between SrMg and iMg by using linear regression analysis. RESULTS Nineteen patients were included. At the end of the infusion, SrMg levels were 4.4 6 0.8 mg/ dL, and iMg levels were 0.95 6 0.2 mmol/L. SrMg levels only moderately predicted iMg (r 2 ¼ 0.541). There were no reports of hypotension, respiratory failure, neurological problems, or nausea. Discomfort at the site of infusion was reported in three cases. Troponin levels (n ¼ 12) and electrocardiograms (n ¼ 12), when available, were noted at the end of the infusion and were normal in all patients p¼0.01. CONCLUSIONS In this case series, short-term high-dose administration of magnesium sulfate in the context of status asthmaticus was feasible, and we did not observe clinical complications with its use. Total SrMg was inadequate to reflect the active form of magnesium, iMg. The dose used achieved theoretical therapeutic levels of iMg.INDEX TERMS asthma, feasibility, infusion, magnesium sulfate, status asthmaticus J Pediatr Pharmacol Ther 2012;17(2):150-154

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“…Ali et al (2007) reported that magnesium sulfate has no effect on sever preeclampsia and eclampsia patients. They suggested that protective drug regimen is not associated with changes in serum calcium levels 30 . However, various studies reported controversial results on serum calcium level in preeclamptic patient compared to individuals with normal blood pressure and there are still some ambiguities 7-10, 31, 32 .…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of Total Albumin and Calcium Level between Preeclamptic Women Undergoing Magnesium Sulfate Therapy and with Normal Pregnancies

Emami¹,

Najib²,

Poordast³

et al. 2015

Biosci., Biotech. Res. Asia

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Magnesium sulfate is used for seizure therapy and profilaxy in women with eclampsia and preeclampsia worldwide. Magnesium has effect on calcium modulation and also there are antithesis reports about alternation between magnesium sulfate therapy and decreased serum calcium level. Decreased in serum calcium level may cause some complications. The present study determines whether maternal serum level of calcium and albumin in patients with preeclampsia are lower than matched control subjects. Thirty patients with preeclampsia who were candidate for received magnesium sulfate therapy compared with 30 normal pregnant women as a control group. Serum calcium and albumin concentration were determined in 3 ml of venous blood sample that was taken before magnesium sulfate therapy, during and 24 hrs after discontinuation of therapy in preeclamptic women and also before and 8 hrs after delivery in normal pregnant women. Findings show no significance difference of maternal and gestational ages between the two groups. The change in mean concentration of albumin, total calcium level, and corrected serum calcium level was observed just significantly at the albumin level 24 hrs after the termination of therapy in preeclamptic group (3 mg/dl, 2.7 mg/dl) P=0.03. There is no any correlation between others items in two groups. In both two groups serum calcium level is more before delivery than after. In the preeclamptic group (9.1 mg/dl, 9 mg/dl) P=0.00 and in normotensive group (9.3 mg/dl, 9 mg/dl) P=0.00. According to this small group study magnesium sulfate therapy in preeclamptic women doesn't redounded to change in serum calcium level, but may lead to increased albumin level after delivery in control subject and also after discontinuation of the therapy in patients groups respectively. Keywords: Preeclampsia, Calcium, Albumin, Magnesium sulfate Preeclampsia has a high prevalence among pregnant women and it can lead to serious complications for them or even death 1, 2 . Magnesium sulfate is a common cure for prevention the eclampsia in these patients 3 . Ionic calcium is antagonized by magnesium ions 4,5 . Therefore, it seems that magnesium sulfate can decrease serum calcium and its adverse effects in preeclamptic patients. Decreased calcium serum is associated with some different effects such as convulsion, muscle spasm especially in the larynx, psychological problems, change in vital signs, and cardiac arrest; so that, it can potentially threaten life 6 . There are also some controversial reports on low calcium contents in preeclamptic patients [7][8][9][10] . In case of low calcium contents, magnesium sulfate can intensify the condition and cause serious complications 6 . Halhali et al. (2001) showed that preeclamptic patients have a low level of 2104 ASKARY et al., Biosci., Biotech. Res. Asia, Vol. 12(3), 2103-2110 (2015) parathormone and injection of magnesium sulfate can increase Calcitonin gene related peptide in them which leads to hypocalcemia 11 . Huang et al. (2004) injected magnesium sulfate to pregnant women...

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Ionized and total magnesium concentration in patients with severe preeclampsia‐eclampsia undergoing magnesium sulfate therapy

Cited by 30 publications

References 21 publications

High-Dose Magnesium Sulfate Infusion for Severe Asthma in the Emergency Department

High-Dose Magnesium Sulfate Infusion for Severe Asthma in the Emergency Department

Feasibility of Short-Term Infusion of Magnesium Sulfate in Pediatric Patients With Status Asthmaticus

A Comparative Study of Total Albumin and Calcium Level between Preeclamptic Women Undergoing Magnesium Sulfate Therapy and with Normal Pregnancies

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