Ionized calcium levels in umbilical cord blood of women with preeclampsia and normotensive pregnancies

Yusuf, Kamran; Kamaluddeen, Majeeda; Hasan, Shabih U.; Al-Awad, Essa; Finch, Robert A.; Akierman, Albert

doi:10.3109/14767058.2011.561895

Cited by 6 publications

(3 citation statements)

References 14 publications

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“…Previous studies have demonstrated that decreased endothelial progenitor cells and ionized calcium levels were found in umbilical cord blood in preeclampsia [12,13]. There were significant differences in nucleated red blood cell count and blood rheological properties in the umbilical cord blood between healthy women and women with preeclampsia [14,15].…”

Section: Introductionmentioning

confidence: 99%

Comparative Proteomic Profile of the Human Umbilical Cord Blood Exosomes between Normal and Preeclampsia Pregnancies with High-Resolution Mass Spectrometry

Jia

Cheng

et al. 2015

Cell Physiol Biochem

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Background/Aims: Exosomes are extracellular vesicles that are involved in several biological processes. The roles of proteins from human umbilical cord blood exosomes in the pathogenesis of preeclampsia remains poorly understood. Methods: In this study, we used high-resolution LC-MS/MS technologies to construct a comparative proteomic profiling of human umbilical cord blood exosomes between normal and preeclamptic pregnancies. Results: A total of 221 proteins were detected in human umbilical cord blood exosomes, with 14 upregulated and 15 downregulated proteins were definitively identified between preeclamptic and control pregnancies. Further bioinformatics analysis (Gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis) indicated that these differentially expressed proteins correlate with enzyme regulator activity, binding, extracellular region, cell part, biological regulation, cellular process and complement and coagulation cascades occurring during pathological changes of preeclampsia. Conclusion: Our results show significantly altered expression profiles of proteins in human umbilical cord blood exosomes between normal and preeclampsia pregnancies. These proteins may be involved in the etiology of preeclampsia.

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Section: Introductionmentioning

confidence: 99%

Comparative Proteomic Profile of the Human Umbilical Cord Blood Exosomes between Normal and Preeclampsia Pregnancies with High-Resolution Mass Spectrometry

Jia

Cheng

et al. 2015

Cell Physiol Biochem

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“…More and more studies have shown that exosomal circrnas are involved in the processes of cell growth, angiogenesis, epithelial mesenchymal transition and targeted therapy [16,17]. And accumulating evidences suggested that it is possible to identify functional and/or structural differences in umbilical cord blood with risk of PE [18][19][20]. Therefore, we speculated that exosomal circRNA in umbilical cord blood might play an important role in the regulation of PE development as a new placental derived factor.…”

Section: Introductionmentioning

confidence: 95%

Differential Circular RNA Expression Profiles in Umbilical Cord Blood Exosomes from Preeclampsia Patients

Cao

Wen

et al. 2021

Preprint

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Exosomal circular RNAs (circRNAs) are emerging as important regulators of physiological development and disease pathogenesis. However, the roles of exosomal circRNAs from umbilical cord blood in preeclampsia (PE) occurrence remains poorly understood. In this study, we used microarray technology to establish the differential circRNA expression profiles in umbilical cord blood exosomes from PE patients compared with normal controls. According to the microarray data, we identified 143 significantly up-regulated circRNAs and 161 significantly down-regulated circRNAs in umbilical cord blood exosomes of PE patients compared with controls. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) biological pathway analyses demonstrated that circRNA parental genes involved in the regulation of metabolic process, trophoblast growth and invasion were significantly enriched, which are important in PE development. Moreover, pathway network was constructed to reveal the key pathways in PE, such as PI3K-Akt signaling pathway. Further circRNA/miRNA interactions analysis showed that most of the exosomal circRNAs harbored miRNA binding sites, and some miRNAs were associated with PE. Collectively, our results highlight the importance of exosomal circRNAs in the pathogenesis of PE and lay a foundation for extensive studies on the role of exosomal circRNAs in PE development.

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“…More and more studies have shown that exosomal circRNAs are involved in the processes of cell growth, angiogenesis, epithelial mesenchymal transition and targeted therapy [ 16 , 17 ]. And accumulating evidences suggested that it is possible to identify functional and/or structural differences in umbilical cord blood with risk of PE [ 18 – 20 ]. Therefore, we speculated that exosomal circRNA in umbilical cord blood might play an important role in the regulation of PE development as a new placental derived factor.…”

Section: Introductionmentioning

confidence: 99%

Differential circular RNA expression profiles in umbilical cord blood exosomes from preeclampsia patients

Cao

Wen

et al. 2021

BMC Pregnancy Childbirth

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Background Exosomal circular RNAs (circRNAs) are emerging as important regulators of physiological development and disease pathogenesis. However, the roles of exosomal circRNAs from umbilical cord blood in preeclampsia (PE) occurrence remains poorly understood. Methods We used microarray technology to establish the differential circRNA expression profiles in umbilical cord blood exosomes from PE patients compared with normal controls. Bioinformatics analysis was conducted to further predict the potential effects of the differentially expressed circRNAs and their interactions with miRNAs. Results According to the microarray data, we identified 143 significantly up-regulated circRNAs and 161 significantly down-regulated circRNAs in umbilical cord blood exosomes of PE patients compared with controls. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) biological pathway analyses showed that circRNA parental genes involved in the regulation of metabolic process, trophoblast growth and invasion were significantly enriched, which play important roles in PE development. Moreover, pathway network was constructed to reveal the key pathways in PE, such as PI3K-Akt signaling pathway. Further circRNA/miRNA interactions analysis demonstrated that most exosomal circRNAs had miRNA binding sites, and some miRNAs were associated with PE. Conclusions Our results highlight the importance of exosomal circRNAs in the pathogenesis of PE and lay a foundation for extensive studies on the role of exosomal circRNAs in PE development.

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Ionized calcium levels in umbilical cord blood of women with preeclampsia and normotensive pregnancies

Cited by 6 publications

References 14 publications

Comparative Proteomic Profile of the Human Umbilical Cord Blood Exosomes between Normal and Preeclampsia Pregnancies with High-Resolution Mass Spectrometry

Comparative Proteomic Profile of the Human Umbilical Cord Blood Exosomes between Normal and Preeclampsia Pregnancies with High-Resolution Mass Spectrometry

Differential Circular RNA Expression Profiles in Umbilical Cord Blood Exosomes from Preeclampsia Patients

Differential circular RNA expression profiles in umbilical cord blood exosomes from preeclampsia patients

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