Ionized Kypocalce K1a Following Fresh Frozen Plasma Administration to Thermally Injured Children

Côté, Christiane; Drop, Lambertus J.; Daniels, Alfred L.; Sanders, Brett; Szyfelbein, S.K.

doi:10.1097/00000542-198409001-00421

Cited by 3 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[4][5][6][7][8] Blood transfusions containing citrate may further exacerbate hypocalcemia. 9 Studies in adults suggest an association between EH and mortality, 10 coagulopathy, 7 shock, 11 and subsequent transfusion requirements. 12,13 The association between hypocalcemia and adverse outcomes was also demonstrated in patients with gastrointestinal, postpartum, and intracranial hemorrhages.…”

Section: Introductionmentioning

confidence: 99%

“…Its incidence is estimated at approximately 50% 4–8 . Blood transfusions containing citrate may further exacerbate hypocalcemia 9 . Studies in adults suggest an association between EH and mortality, 10 coagulopathy, 7 shock, 11 and subsequent transfusion requirements 12,13 .…”

Section: Introductionmentioning

confidence: 99%

“…The median age was 11 years (interquartile range [IQR], 4-15), and 78.4% (87) were male. The median ISS was 21 (IQR, 17-27).Hypocalcemia was found in 19.8% ( 22) and severe hypocalcemia in 2.7% (3) of the patients.Although not statistically significant, hypocalcemic pediatric trauma patients had higher ISS (25.5 [IQR,(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29) vs 21 [IQR,[17][18][19][20][21][22][23][24][25][26], P = 0.39), lower Glasgow Coma Scale (11 [IQR,[3][4][5][6][7][8][9][10][11][12][13][14][15] vs 13 [IQR, 7-15], P = 0.24), a more prolonged hospital stay (8 days [IQR, 2-16] vs 6 days [IQR, 3-13], P = 0.36), a more frequent need for blood products (27.3% vs 20.2%, P = 0.74), and higher mortality rates (9.1% vs 1.1%, P = 0.18) compared with normocalcemic patients.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Early Hypocalcemia in Pediatric Major Trauma

et al. 2022

View full text Add to dashboard Cite

ObjectiveEarly hypocalcemia (EH) is common in adult major trauma patients and has been associated with coagulopathy, shock, increased transfusion requirements, and mortality. The incidence of EH in pediatric severe trauma has not been investigated. We aimed to explore the incidence of EH among severely injured children.MethodsWe conducted a retrospective cohort study at a tertiary children's hospital and a level 1 pediatric trauma center. We extracted the medical records of all pediatric major trauma patients, defined as an age less than 18 years and an Injury Severity Score (ISS) greater than 15, admitted after trauma team activation from January 2010 to December 2020.The primary outcome was the presence of EH. Patients were classified into 3 groups: severe hypocalcemia (ionized calcium [iCa] <1 mmol/L), hypocalcemia (1 < iCa < 1.16 mmol/L), and normal calcium (iCa ≥1.16 mmol/L).ResultsDuring the study period, 5126 children were hospitalized because of trauma. One hundred eleven children met the inclusion criteria. The median age was 11 years (interquartile range [IQR], 4–15), and 78.4% (87) were male. The median ISS was 21 (IQR, 17–27).Hypocalcemia was found in 19.8% (22) and severe hypocalcemia in 2.7% (3) of the patients.Although not statistically significant, hypocalcemic pediatric trauma patients had higher ISS (25.5 [IQR, 17–29] vs 21 [IQR, 17–26], P = 0.39), lower Glasgow Coma Scale (11 [IQR, 3–15] vs 13 [IQR, 7–15], P = 0.24), a more prolonged hospital stay (8 days [IQR, 2–16] vs 6 days [IQR, 3–13], P = 0.36), a more frequent need for blood products (27.3% vs 20.2%, P = 0.74), and higher mortality rates (9.1% vs 1.1%, P = 0.18) compared with normocalcemic patients.ConclusionsOur data suggest that in the setting of major trauma, EH is less frequent in children than previously reported in adults. Our preliminary data suggest that pediatric patients with EH may be at risk of increased morbidity and mortality compared with children with normal admission iCa requiring further studies.

show abstract