Ionized Magnesium in Critically Ill Patients as Measured by an Ion Selective Electrode

Magnesium affects cardiac function, although until the recent development of a new ion-selective electrode no method existed for measuring the physiologically active form of magnesium, free ions (iMg2+), in the blood. We investigated the antiarrhythmic effect of magnesium sulfate administered to critically ill patients with cardiac arrhythmias and reduced iMg2+ as determined using the ion-selective electrode. Eight patients with a low iMg2+ level (less than 0.40 mmol/L) were given intravenous magnesium sulfate (group L). Magnesium sulfate was also administered to patients with a normal iMg2+ level (more than 0.40 mmol/L) but who did not respond to conventional antiarrhythmic drugs (group N). Intravenous magnesium sulfate significantly increased the iMg2+ level in patients in group L from 0.35 +/- 0.06 mmol/L (mean +/- SD) to 0.54 +/- 0.09 mmol/L (p < 0.01), and had an antiarrhythmic effect in 7 of the 8 patients (88%). However, in group N patients, intravenous magnesium sulfate had an antiarrhythmic effect in only 1 of the 6 patients (17%) (p < 0.05 vs group L). These results suggest that intravenous magnesium sulfate may be effective in the acute management of cardiac arrhythmias in patients with a low serum iMg2+ level.

show abstract

Effect of Intravenous Magnesium Sulfate on Cardiac Arrhythmias in Critically III Patients with Low Serum Ionized Magnesium

Kasaoka

Tsuruta

Nakashima

et al. 1996

Jpn Circ J

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Ionized Magnesium in Critically Ill Patients as Measured by an Ion Selective Electrode

Abstract: Ionized magnesium and calcium in critically ill patients 10) Mauskop A, Altura BT, Cracco RQ, et al. Deficiency in serum ionized magnesium but not total magnesium in patients with migraines. Possible role of iCa2+/iMg2+ ratio. Headache 1993;

Cited by 1 publication

References 6 publications

Effect of Intravenous Magnesium Sulfate on Cardiac Arrhythmias in Critically III Patients with Low Serum Ionized Magnesium

Effect of Intravenous Magnesium Sulfate on Cardiac Arrhythmias in Critically III Patients with Low Serum Ionized Magnesium

Contact Info

Product

Resources

About