Ionizing radiation and the cell cycle: A review

Abstract

SUMMARY Ionizing radiation has long been known to cause perturbations in the cell cycle. The information regarding these effects on the cell cycle, in particular alterations in cell cycle kinetics, has been used to design various treatment protocols over the years; these efforts have resulted in modest improvements in local control and patient survival. However, the past two decades have seen an eruption of scientific knowledge regarding the molecular biology of the cell cycle, specifically the regulation of cell cycle checkpoints. In this review we discuss the genetic events involved in regulating the G1, S, and G2 checkpoints. In addition, we discuss the potential impact of the recent cloning of the gene for ataxia-telangiectasia. Radiat

c‐IAP2 is induced by ionizing radiation through NF‐κB binding sites

“…Since the stimulation by X‐rays is instantaneous and the radiosensitivity of cells is based on their progression through the cell cycle [13], it is difficult to adjust all the cell populations in the best timing for the screening assay. Thus for the primary screening for trap lines, we used BLM as a radiomimetic drug.…”