Ionizing radiation-engineered nanogels as insulin nanocarriers for the development of a new strategy for the treatment of Alzheimer's disease

Picone, Pasquale; Ditta, Lorena Anna; Sabatino, Maria Antonietta; Militello, Valeria; Biagio, Pier Luigi San; Giacinto, Maria Laura Di; Cristaldi, Laura; Nuzzo, Domenico; Dispenza, Clelia; Giacomazza, Daniela; Carlo, Marta Di

doi:10.1016/j.biomaterials.2015.11.057

Cited by 101 publications

(63 citation statements)

References 61 publications

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“…Since the first appearance of this family of nanoscale materials, their application as biocompatible carriers for a large plethora of biomedical and biotechnological applications has been explored [3][4][5]. In particular, these soft materials have gained growing interest for drug delivery because of their high loading capacity and stability [6][7][8][9][10], showing also potential use as pH and temperature sensors [11,12]. They are also employed as in vivo imaging tracers [13], in water treatment [14] and catalysis [15], as smart gating membranes for the fabrication of active photonic crystals and coatings, and for generating bioactive scaffolds in regenerative medicine [16].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of polymer nanogels by electro-Fenton process: investigation of the effect of main operation parameters

Lanzalaco

Sirés

Sabatino

et al. 2017

Electrochimica Acta

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Recently, electro-Fenton (EF) process has been shown as a promising, facile, effective, low cost and environmentally-friendly alternative for synthesizing polymer nanogels suitable as biocompatible nanocarriers for emerging biomedical applications. Here, the electrochemically-assisted modification of poly(vinylpyrrolidone) (PVP) by EF process was studied to assess the role of key operation parameters for a precise modulation of polymer crosslinking and its functionalization with [sbnd]COOH and succinimide groups. The dimensions of the nanogels, in terms of hydrodynamic radius (Rh) and weight-average molecular weight (Mw), can be tuned up by controlling the electrolysis time, current density (j) and PVP and Fe2+concentrations, as demonstrated via dynamic and static light scattering and gel permeation chromatography analysis. Using PVP at 0.25Â wt.%, Fe2+at 0.5-1.0Â mmolÂ dmâ\u88\u923and low j, short treatment times induced intramolecular crosslinking with chain scission, allowing size reduction of PVP particles from 24 to 9â\u80\u9310Â nm. Longer reaction times and higher PVP and Fe2+contents favored intermolecular crosslinking ending in Mwvalues higher than the initial 3.95Â Ã\u97Â 105Â gÂ molâ\u88\u921. An excessive [rad]OH dose from a too high circulated charge (Q), i.e., too prolonged electrolysis time even at low j or too high j even for short time, promoted intramolecular crosslinking (RhÂ â\u88¼Â 10â\u80\u9312Â nm) along with a very significant chain scission probably owing to the loss of mobility of the three-dimensional nanogel network. In conclusion, EF allowed transforming the architecture of linear, inert PVP chains into a functionalized nanogel with [sbnd]COOH and succinimide groups that have great potential for further conjugation

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Section: Introductionmentioning

confidence: 99%

Synthesis of polymer nanogels by electro-Fenton process: investigation of the effect of main operation parameters

Lanzalaco

Sirés

Sabatino

et al. 2017

Electrochimica Acta

Self Cite

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“…Poly(N-vinyl pyrrolidone)-co-acrylic acid nanogels (NG) were produced and insulin was grafted onto the surface. It is demonstrated that the grafted insulin is capable of activate AKT signaling and the nanogel can be efficiently transported to across the BBB, protecting insulin from protease degradation, and overall, producing a neuroprotective effect against the damage induce by Aβ [220].…”

Section: Treatment Of Inflammation or Oxidative Stressmentioning

confidence: 99%

Targeted Nanoparticles for the Treatment of Alzheimer's Disease

Martín‐Rapún

Matteis

Ambrosone

et al. 2017

CPD

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“…to the cerebrum, thereby compromising the outcomes of diagnosis and therapy . With the increasing development of nanomaterials, receptor‐mediated transcytosis (RMT) has become one of the most promising protocols to overcome the BBB through receptors that are highly expressed on BBB endothelial cells, among which transferrin receptor (TfR) is a promising candidate . Moreover, TfR is also present in substantial quantities on GBM cells due to their high proliferation rate and iron demand .…”

Section: Introductionmentioning

confidence: 99%

Intelligent Nanocomposites with Intrinsic Blood–Brain‐Barrier Crossing Ability Designed for Highly Specific MR Imaging and Sonodynamic Therapy of Glioblastoma

Liang

Luo

et al. 2020

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The blood–brain barrier (BBB) is the most important obstacle to improving the clinical outcomes of diagnosis and therapy of glioblastoma. Thus, the development of a novel nanoplatform that can efficiently traverse the BBB and achieve both precise diagnosis and therapy is of great importance. Herein, an intelligent nanoplatform based on holo‐transferrin (holo‐Tf) with in situ growth of MnO2 nanocrystals is constructed via a reformative mild biomineralization process. Furthermore, protoporphyrin (ppIX), acting as a sonosensitizer, is then conjugated into holo‐Tf to obtain MnO2@Tf‐ppIX nanoparticles (TMP). Because of the functional inheritance of holo‐Tf during fabrication, TMP can effectively traverse the BBB for highly specific magnetic resonance (MR) imaging of orthotopic glioblastoma. Clear suppression of tumor growth in a C6 tumor xenograft model is achieved via sonodynamic therapy. Importantly, the experiments also indicate that the TMP nanoplatform has satisfactory biocompatibility and biosafety, which favors potential clinical translation.

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Ionizing radiation-engineered nanogels as insulin nanocarriers for the development of a new strategy for the treatment of Alzheimer's disease

Cited by 101 publications

References 61 publications

Synthesis of polymer nanogels by electro-Fenton process: investigation of the effect of main operation parameters

Synthesis of polymer nanogels by electro-Fenton process: investigation of the effect of main operation parameters

Targeted Nanoparticles for the Treatment of Alzheimer's Disease

Intelligent Nanocomposites with Intrinsic Blood–Brain‐Barrier Crossing Ability Designed for Highly Specific MR Imaging and Sonodynamic Therapy of Glioblastoma

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