Ionizing radiation-induced bystander effects, potential targets for modulation of radiotherapy

Rzeszowska-Wolny, Joanna; Przybyszewski, Waldemar M.; Wideł, Maria

doi:10.1016/j.ejphar.2009.07.028

Cited by 101 publications

(66 citation statements)

References 99 publications

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“…These data indicate that decay of p-H2AX foci in WT BM-EPCs ex vivo is slow within the first 24 h, which may be indicative of delayed or inefficient radiation-induced DNA damage repair. In addition, significant increase in mean foci/cell on day 7 post-IR along with an increase in the percentage of p-H2AX foci/cell may be indicative of significant radiobiological bystander responses in BM-EPCs (3,4,6,7,65).…”

Section: Tnfr2/p75 Regulate Ir-induced Nontargeted Effectsmentioning

confidence: 99%

TNF-TNFR2/p75 Signaling Inhibits Early and Increases Delayed Nontargeted Effects in Bone Marrow-derived Endothelial Progenitor Cells

Sasi¹,

Song²,

Park³

et al. 2014

Journal of Biological Chemistry

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Background: Ionizing radiation can induce DNA damage in nonirradiated (N-IR) cells via nontargeted effects (NTE). Results: TNF-␣ and IL-1␣ mediate NTE in N-IR bone marrow-derived EPCs, and neutralizing TNF-␣ diminishes NTE in WT and p55 knock-out BM-EPCs. Conclusion: TNF-TNFR2/p75 signaling alters accumulation of inflammatory cytokines that attenuate NTE in N-IR EPCs. Significance: TNFR2/p75 may represent a gene target for mitigation of delayed RBR in BM-EPCs.

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Section: Tnfr2/p75 Regulate Ir-induced Nontargeted Effectsmentioning

confidence: 99%

TNF-TNFR2/p75 Signaling Inhibits Early and Increases Delayed Nontargeted Effects in Bone Marrow-derived Endothelial Progenitor Cells

Sasi¹,

Song²,

Park³

et al. 2014

Journal of Biological Chemistry

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“…These biological effects are attributed to unrepaired or misrepaired DNA damage in cells directly hit by radiation. However, the effects of ionizing radiation also extend to cells that were not themselves irradiated, but were neighbors or the progeny of irradiated cells [Huang et al, 2007;Sowa, 2007, 2009;Kovalchuk and Baulch, 2008;Rzeszowska-Wolny et al, 2009;Wright, 2010]. The molecular mechanisms of these non-targeted effects are a matter of intensive investigation and are not fully understood.…”

Section: Introductionmentioning

confidence: 99%

Direct and delayed X‐ray‐induced DNA damage in male mouse germ cells

Cordelli¹,

Eleuteri²,

Grollino³

et al. 2012

Environ and Mol Mutagen

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Sperm DNA integrity is essential for the accurate transmission of paternal genetic information. Various stages of spermatogenesis are characterized by large differences in radiosensitivity. Differentiating spermatogonia are susceptible to radiationinduced cell killing, but some of them can repair DNA damage and progress through differentiation. In this study, we applied the neutral comet assay, immunodetection of phosphorylated H2AX (g-H2AX) and the Sperm Chromatin Structure Assay (SCSA) to detect DNA strand breaks in testicular cells and spermatozoa at different times following in vivo X-ray irradiation. Radiation produced DNA strand breaks in testicular cells that were repaired within the first few hours after exposure. Spermatozoa were resistant to the induction of DNA damage, but non-targeted DNA lesions were detected in spermatozoa derived from surviving irradiated spermatogonia. These lesions formed while round spermatids started to elongate within the testicular seminiferous tubules. The transcription of pro-apoptotic genes at this time was also enhanced, suggesting that an apoptotic-like process was involved in DNA break production. Our results suggest that proliferating spermatogonia retain a memory of the radiation insult that is recognized at a later developmental stage and activates a process leading to DNA fragmentation. Environ. Mol. Mutagen. 53:429-439, 2012. V V C 2012 Wiley Periodicals, Inc.

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“…In addition, IR has 'bystander effects' induced by signals from irradiated cells, which decreases clonogenic survival, induces genetic instability by elevated sister chromatid exchanges and promotes apoptosis as well as significant alterations in gene expression (4) . Exposure to IR leads to cell death or apoptosis through DNA damage by inducing DNA single-strand breaks (SSBs) and double-strand breaks (DSBs) (4 -6) .…”

Section: Introductionmentioning

confidence: 99%

Effects of Ionising Radiation on Micronucleus Formation and Chromosomal Aberrations in Chinese Radiation Workers

Qin

Cao

Shen

et al. 2015

Radiat Prot Dosimetry

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This study is aimed to investigate the effects of ionising radiation (IR) on micronuclei (MN) formation and chromosome aberrations (CAs) in Chinese radiation workers. The study was conducted using peripheral blood lymphocytes from 1392 radiation workers from Public Hospitals of the city of Tangshan (the exposed group), and 143 healthy individuals as the control group. Fluorescence in situ hybridisation (FISH) was used to detect the unstable and stable nuclear CAs on metaphase. The MN assay was performed using the cytochalasin B method for cytokinesis-block. The MN and CA frequencies were significantly higher in the exposed group than in healthy controls (both p < 0.001). Examination of the incidence rates of MN and CA showed an increasing trend among workers in some occupations compared with the others (all p < 0.05). There were also significant differences in MN and CA rates among workers with different exposure times (all p < 0.05). Stable CA rates demonstrated an increased trend among workers with different exposure times (all p < 0.05), while no significance of unstable CA rates was found among workers with different exposure times (all p < 0.05). Importantly, the frequencies of CA and MN increased among different cumulative radiation dose groups (all p < 0.05). Correlation analysis showed that the frequencies of MN and CA were positively associated with the cumulative radiation dose. Longterm exposure to IR may have harmful effects on the health of radiation workers. The data obtained here show an increased risk of genetic instability that correlated with occupation, exposure time and equivalent dose among Chinese radiation workers.

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Ionizing radiation-induced bystander effects, potential targets for modulation of radiotherapy

Cited by 101 publications

References 99 publications

TNF-TNFR2/p75 Signaling Inhibits Early and Increases Delayed Nontargeted Effects in Bone Marrow-derived Endothelial Progenitor Cells

TNF-TNFR2/p75 Signaling Inhibits Early and Increases Delayed Nontargeted Effects in Bone Marrow-derived Endothelial Progenitor Cells

Direct and delayed X‐ray‐induced DNA damage in male mouse germ cells

Effects of Ionising Radiation on Micronucleus Formation and Chromosomal Aberrations in Chinese Radiation Workers

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