Ionizing radiation-induced circulatory and metabolic diseases

Tapio, Soile; Little, Mark P.; Kaiser, Jan Christian; Impens, Nathalie; Hamada, Nobuyuki; Georgakilas, Alexandros G.; Simar, David; Salomaa, Sisko

doi:10.1016/j.envint.2020.106235

Cited by 92 publications

(68 citation statements)

References 196 publications

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“…However, the clinical trials using PPARα agonists have shown contradictory outcomes so far (75). We suggest that administering such agonists could be particularly beneficial in connection with radiation therapy for thoracic malignancies where the heart may receive considerable radiation doses leading to adverse cardiovascular events (76). Furthermore, the data from this serum study could be beneficial in identifying patients who may develop radiation-associated cardiac toxicity.…”

Section: Discussionmentioning

confidence: 93%

Data-Independent Acquisition Proteomics Reveals Long-Term Biomarkers in the Serum of C57BL/6J Mice Following Local High-Dose Heart Irradiation

Azimzadeh

Toerne

Subramanian

et al. 2021

Front. Public Health

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Background and Purpose: Cardiotoxicity is a well-known adverse effect of radiation therapy. Measurable abnormalities in the heart function indicate advanced and often irreversible heart damage. Therefore, early detection of cardiac toxicity is necessary to delay and alleviate the development of the disease. The present study investigated long-term serum proteome alterations following local heart irradiation using a mouse model with the aim to detect biomarkers of radiation-induced cardiac toxicity.Materials and Methods: Serum samples from C57BL/6J mice were collected 20 weeks after local heart irradiation with 8 or 16 Gy X-ray; the controls were sham-irradiated. The samples were analyzed by quantitative proteomics based on data-independent acquisition mass spectrometry. The proteomics data were further investigated using bioinformatics and ELISA.Results: The analysis showed radiation-induced changes in the level of several serum proteins involved in the acute phase response, inflammation, and cholesterol metabolism. We found significantly enhanced expression of proinflammatory cytokines (TNF-α, TGF-β, IL-1, and IL-6) in the serum of the irradiated mice. The level of free fatty acids, total cholesterol, low-density lipoprotein (LDL), and oxidized LDL was increased, whereas that of high-density lipoprotein was decreased by irradiation.Conclusions: This study provides information on systemic effects of heart irradiation. It elucidates a radiation fingerprint in the serum that may be used to elucidate adverse cardiac effects after radiation therapy.

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Section: Discussionmentioning

confidence: 93%

Data-Independent Acquisition Proteomics Reveals Long-Term Biomarkers in the Serum of C57BL/6J Mice Following Local High-Dose Heart Irradiation

Azimzadeh

Toerne

Subramanian

et al. 2021

Front. Public Health

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“…There have been various recent reviews of candidate biological mechanisms (Schultz-Hector and Trott 2007;Little et al 2008;McMillan et al 2010;Bernstein et al 2020;Tapio et al 2021). After very high (>5 Gy) dose acute exposures a number of tissue reaction (formerly deterministic) effects are observed.…”

Section: Circulatory Diseasementioning

confidence: 99%

Low- and moderate-dose non-cancer effects of ionizing radiation in directly exposed individuals, especially circulatory and ocular diseases: a review of the epidemiology

Little

Azizova

Hamada

2021

International Journal of Radiation Biology

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Purpose: There are well-known correlations between high and moderate doses (>0.5 Gy) of ionizing radiation exposure and circulatory system damage, also between radiation and posterior subcapsular cataract. At lower dose correlations with circulatory disease are emerging in the Japanese atomic bomb survivors and in some occupationally exposed groups, and are still to some extent controversial. Heterogeneity in excess relative risks per unit dose in epidemiological studies at low (<0.1 Gy) and at low-moderate (>0.1 Gy, <0.5 Gy) doses may result from confounding and other types of bias, and effect modification by established risk factors. There is also accumulating evidence of excess cataract risks at lower dose and low dose rate in various cohorts. Other ocular endpoints, specifically glaucoma and macular degeneration have been little studied. In this paper, we review recent epidemiological findings, and also discuss some of the underlying radiobiology of these conditions. We briefly review some other types of mainly neurological nonmalignant disease in relation to radiation exposure. Conclusions: We document statistically significant excess risk of the major types of circulatory disease, specifically ischemic heart disease and stroke, in moderate-or low-dose exposed groups, with some not altogether consistent evidence suggesting dose-response non-linearity, particularly for stroke. However, the patterns of risk reported are not straightforward. We also document evidence of excess risks at lower doses/dose-rates of posterior subcapsular and cortical cataract in the Chernobyl liquidators, US Radiologic Technologists and Russian Mayak nuclear workers, with fundamentally linear dose-response. Nuclear cataracts are less radiogenic. For other ocular endpoints, specifically glaucoma and macular degeneration there is very little evidence of effects at low doses; radiation-associated glaucoma has been documented only for doses >5 Gy, and so has the characteristics of a tissue reaction. There is some evidence of neurological detriment following low-moderate dose ($0.1-0.2 Gy) radiation exposure in utero or in early childhood.

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“…Some non-cancer effects might be better classified as stochastic effects. Evidence for increased risk of diseases of the circulatory system following exposure to ionising radiation at low to moderate doses and dose-rates has accumulated from epidemiological studies over the recent decade (Azizova et al 2015 ; Tapio et al 2021 ; Little et al 2021 ). These results show an increase in the probability of occurrence with dose, with no variation in severity.…”

Section: Research To Support Radiation Risk Assessmentmentioning

confidence: 99%

Areas of research to support the system of radiological protection

Laurier

Rühm

Paquet

et al. 2021

Radiat Environ Biophys

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This document presents the ICRP's updated vision on “Areas of Research to Support the System of Radiological Protection”, which have been previously published in 2017. It aims to complement the research priorities promoted by other relevant international organisations, with the specificity of placing them in the perspective of the evolution of the System of Radiological Protection. This document contributes to the process launched by ICRP to review and revise the System of Radiological Protection that will update the 2007 General Recommendations in ICRP Publication 103.

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Ionizing radiation-induced circulatory and metabolic diseases

Cited by 92 publications

References 196 publications

Data-Independent Acquisition Proteomics Reveals Long-Term Biomarkers in the Serum of C57BL/6J Mice Following Local High-Dose Heart Irradiation

Data-Independent Acquisition Proteomics Reveals Long-Term Biomarkers in the Serum of C57BL/6J Mice Following Local High-Dose Heart Irradiation

Low- and moderate-dose non-cancer effects of ionizing radiation in directly exposed individuals, especially circulatory and ocular diseases: a review of the epidemiology

Areas of research to support the system of radiological protection

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