Ionizing Radiation Therapy in Dermatology

Goldschmidt, Herbert

doi:10.1001/archderm.1975.01630230113021

Cited by 47 publications

(39 citation statements)

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“…Treatment for cutaneous malignancy traditionally has included excision, electrosurgery, cryosurgery and radiotherapy; currently there is increasing interest in the use of photodynamic therapy, lasers and imiquimod. Historically, radiation therapy has been useful in the management of skin cancer 1–5 . Introduction of sophisticated surgical methods and increased public awareness of radiation toxicity have resulted in limited use of radiation therapy by dermatologists.…”

Section: Introductionmentioning

confidence: 99%

Office‐based radiation therapy for cutaneous carcinoma: Evaluation of 710 treatments

et al. 2007

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Skin cancers are the most common malignancies and, historically, ionizing radiation has played an important role in their treatment. However, less experienced dermatologists generally consider radiation last in the line of therapeutic options. The authors sought to evaluate the effectiveness and safety of office-based elective radiation therapy for cutaneous carcinoma. A retrospective study of 604 basal cell carcinomas (BCCs) and 106 squamous cell carcinomas (SCCs) irradiated between 1971-96 was performed. The percentage of patients who developed tumor recurrence during the follow-up period was calculated using Kaplan-Meier survival curves. Cox's proportional model was used to assess the prognostic factors that might have influenced the recurrences. The recurrence rates for BCC and SCC were 11.5 and 16.5 per 1000 patient-years, respectively. The 5-year cure rates were 94.4% for BCC and 92.7% for SCC, and the 15-year cure rates were 84.8% and 78.6%, respectively. Tumor location on the nasolabial fold (OR 4.4; 95% IC, 1.3-14.7) and tumor size > or = 10 mm (OR 2.14; 95% IC, 1.03-4.45) were independent predictors of BCC recurrence. This study suggested that radiation therapy is an effective treatment for BCC and SCC and should be considered as a first option in many cases.

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Section: Introductionmentioning

confidence: 99%

Office‐based radiation therapy for cutaneous carcinoma: Evaluation of 710 treatments

et al. 2007

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“…This suspicion is reinforced by a previous report by Maher et al who described a patient with a preexisting HS who had a flare of HS over the entire radiation site after treatment for ductal in situ carcinoma; the authors suggested that radiation-induced apoptosis and the enhanced skin immune response were the main factors of HS exacerbation 3, 4…”

Section: Discussionmentioning

confidence: 98%

Radiation-induced hidradenitis suppurativa: A case report

et al. 2017

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“…Radiotherapy has a very limited role in the management of melanoma. [29] Postoperative radiotherapy is indicated in patients with advanced lesions, positive margins, lymph node metastasis, in-transit metastases in melanoma, and for palliation. [30]…”

Section: Discussionmentioning

confidence: 99%