Ionomics and metabolomics analysis reveal the molecular mechanism of metal tolerance of Pteris vittata L. dominating in a mining site in Thai Nguyen province, Vietnam

Nguyen, Ngoc-Lien; Bui, Van Hoi; Pham, Hoang Nam; To, Hien-Minh; Dijoux‐Franca, Marie‐Geneviève; Vu, Cam-Tu; Nguyen, Thi Kieu Oanh

doi:10.1007/s11356-022-21820-8

Cited by 11 publications

(5 citation statements)

References 62 publications

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“…The shoots’ multi-element compositions were analyzed using inductively coupled plasma optical emission spectroscopy (ICP-OES), referred to as the “ionomics” approach [ 12 ]. Frozen plant material (150 mg) from Section 4.1 was digested according to the method reported by Huang et al [ 29 ], and the frozen plant material was inserted into 2 mL Eppendorf tubes, to which 1 mL of 65% nitric acid was added.…”

Section: Methodsmentioning

confidence: 99%

“…However, apart from these studies, which have reported on physiological and biochemical changes, there seems to be a dearth of data on molecular or ion-omics studies. This lack of data is surprising when considering that plant ion-omics have provided insights into how plants respond to environmental stimuli, such as salinity, drought, or nutrient deficiencies, and how they regulate ion homeostasis to maintain optimal growth and development [ 12 ]. Thus, investigations into ion or mineral uptake involving phenolic acids holds promise for understanding how these compounds confer tolerance against salt stress.…”

Section: Introductionmentioning

confidence: 99%

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p-Coumaric Acid Differential Alters the Ion-Omics Profile of Chia Shoots under Salt Stress

Nkomo,

Badiwe,

Niekerk

et al. 2024

Plants

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p-Coumaric acid (p-CA) is a phenolic compound that plays a crucial role in mediating multiple signaling pathways. It serves as a defense strategy against plant wounding and is also presumed to play a role in plant development and lignin biosynthesis. This study aimed to investigate the physiological and ionomic effect of p-CA on chia seedlings under salt stress. To this end, chia seedlings were supplemented with Nitrosol® containing 100 μM of p-CA,100 of mM NaCI, and their combined (100 mM NaCI + 100 μM p-CA) solutions in 2-day intervals for a period of 14 days along with a control containing Nitrosol® only. The treatment of chia seedlings with 100 mM of NaCI decreased their growth parameters and the content of the majority of the essential macro-elements (K, P, Ca, and Mg), except for that of sodium (Na). The simultaneous application of p-CA and a salt stress treatment (p-CA + NaCI) alleviated the effect of salt stress on chia seedlings’ shoots, and this was indicated by the increase in chia biomass. Furthermore, this combined treatment significantly enhanced the levels of the essential microelements Mg and Ca. In summary, this brief report is built on the foundational work of our previous study, which demonstrated that p-CA promotes growth in chia seedlings via activation of O2−. In this brief report, we further show that p-CA not only promotes growth but also mitigates the effects of salt stress on chia seedlings. This mitigation effect may result from the presence of Mg and Ca, which are vital nutrients involved in regulating metabolic pathways, enzyme activity, and amino acid synthesis.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

p-Coumaric Acid Differential Alters the Ion-Omics Profile of Chia Shoots under Salt Stress

Nkomo,

Badiwe,

Niekerk

et al. 2024

Plants

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“…Naika et al ( 2013 ) developed a dataset of stress-responsive signals in A. thaliana under various stresses (including Al and Fe toxicity), identifying several shared and unshared biological processes, molecular functions, metabolic pathways, and phenomic traits that may help with the design of stress–smart advanced varieties using genome editing tools. The phenome method was used to detect genetic diversity in root system architecture traits in soybean accessions, revealing similarities in genotype- and phenotype-based clusters, with genotype-based clusters correlated with geographical backgrounds (Falk et al 2020 ).…”

Section: Integrating Omics Data With Artificial Intelligence and High...mentioning

confidence: 99%

Transcriptomics, proteomics, and metabolomics interventions prompt crop improvement against metal(loid) toxicity

Raza,

Salehi,

Bashir

et al. 2024

Plant Cell Rep

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The escalating challenges posed by metal(loid) toxicity in agricultural ecosystems, exacerbated by rapid climate change and anthropogenic pressures, demand urgent attention. Soil contamination is a critical issue because it significantly impacts crop productivity. The widespread threat of metal(loid) toxicity can jeopardize global food security due to contaminated food supplies and pose environmental risks, contributing to soil and water pollution and thus impacting the whole ecosystem. In this context, plants have evolved complex mechanisms to combat metal(loid) stress. Amid the array of innovative approaches, omics, notably transcriptomics, proteomics, and metabolomics, have emerged as transformative tools, shedding light on the genes, proteins, and key metabolites involved in metal(loid) stress responses and tolerance mechanisms. These identified candidates hold promise for developing high-yielding crops with desirable agronomic traits. Computational biology tools like bioinformatics, biological databases, and analytical pipelines support these omics approaches by harnessing diverse information and facilitating the mapping of genotype-to-phenotype relationships under stress conditions. This review explores: (1) the multifaceted strategies that plants use to adapt to metal(loid) toxicity in their environment; (2) the latest findings in metal(loid)-mediated transcriptomics, proteomics, and metabolomics studies across various plant species; (3) the integration of omics data with artificial intelligence and high-throughput phenotyping; (4) the latest bioinformatics databases, tools and pipelines for single and/or multi-omics data integration; (5) the latest insights into stress adaptations and tolerance mechanisms for future outlooks; and (6) the capacity of omics advances for creating sustainable and resilient crop plants that can thrive in metal(loid)-contaminated environments.

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“…Recently, Nguyen and coworkers revealed the mechanism of metal accumulation in P. vittata dominating the Thai Nguyen mining sites. Secondary metabolites of P. vittata were identified, including 70 flavonoids, 14 benzoic acids, 16 phenylpropanoic acid derivatives, 2 stilbenoids, 9 phenols, 20 alkaloids, 5 coumarins, and 3 terpenoids [ 75 ]. Among them, quercetin has shown remarkable properties as an antibacterial agent and an EPI.…”

Section: Secondary Metabolites Production Of Plants As Potential Epismentioning

confidence: 99%

Efflux Pump Inhibitors in Controlling Antibiotic Resistance: Outlook under a Heavy Metal Contamination Context

Nguyen

et al. 2023

Molecules

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Multi-drug resistance to antibiotics represents a growing challenge in treating infectious diseases. Outside the hospital, bacteria with the multi-drug resistance (MDR) phenotype have an increased prevalence in anthropized environments, thus implying that chemical stresses, such as metals, hydrocarbons, organic compounds, etc., are the source of such resistance. There is a developing hypothesis regarding the role of metal contamination in terrestrial and aquatic environments as a selective agent in the proliferation of antibiotic resistance caused by the co-selection of antibiotic and metal resistance genes carried by transmissible plasmids and/or associated with transposons. Efflux pumps are also known to be involved in either antibiotic or metal resistance. In order to deal with these situations, microorganisms use an effective strategy that includes a range of expressions based on biochemical and genetic mechanisms. The data from numerous studies suggest that heavy metal contamination could affect the dissemination of antibiotic-resistant genes. Environmental pollution caused by anthropogenic activities could lead to mutagenesis based on the synergy between antibiotic efficacy and the acquired resistance mechanism under stressors. Moreover, the acquired resistance includes plasmid-encoded specific efflux pumps. Soil microbiomes have been reported as reservoirs of resistance genes that are available for exchange with pathogenic bacteria. Importantly, metal-contaminated soil is a selective agent that proliferates antibiotic resistance through efflux pumps. Thus, the use of multi-drug efflux pump inhibitors (EPIs) originating from natural plants or synthetic compounds is a promising approach for restoring the efficacy of existing antibiotics, even though they face a lot of challenges.

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Ionomics and metabolomics analysis reveal the molecular mechanism of metal tolerance of Pteris vittata L. dominating in a mining site in Thai Nguyen province, Vietnam

Cited by 11 publications

References 62 publications

p-Coumaric Acid Differential Alters the Ion-Omics Profile of Chia Shoots under Salt Stress

p-Coumaric Acid Differential Alters the Ion-Omics Profile of Chia Shoots under Salt Stress

Transcriptomics, proteomics, and metabolomics interventions prompt crop improvement against metal(loid) toxicity

Efflux Pump Inhibitors in Controlling Antibiotic Resistance: Outlook under a Heavy Metal Contamination Context

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