Ionophore-based ion-selective electrodes: signal transduction and amplification from potentiometry

Abstract

Ionophore-based ion-selective electrodes (ISEs) are traditionally operated with potentiometry by measuring the open circuit potential against a reference electrode. However, the sensitivity of ISEs is limited by the well-known Nernstian...

Design and application of potentiometric sensors for the determination of mefenamic and phenylanthranilic acids

“…The electrode potential changes linearly in the Nernst response region. [1][2][3][4][5] A growing number of new theoretical and application achievements in potentiometry has appeared worldwide. One of the research directions in the eld of potentiometry is the development of new potentiometric sensors to obtain the most favourable analytical parameters.…”

Ion-selective membrane modified microfluidic paper-based solution sampling substrates for potentiometric heavy metal detection

“…5–9 Recently, the applications of ISEs have been enhanced by the conversion of electric potential in an ISE into other optical 10,11 or electrochemical 12,13 signals to improve sensitivity. 14…”

“…[5][6][7][8][9] Recently, the applications of ISEs have been enhanced by the conversion of electric potential in an ISE into other optical 10,11 or electrochemical 12,13 signals to improve sensitivity. 14 The use of microfluidic paper-based substrates for solution sampling rather than the traditional beaker-based measure-ments adds advantages to the analytical protocol of specific sample types, e.g. it requires only a small sample volume and allows analysis of samples consisting of high solid-to-liquid ratios.…”

Detection of Interfering Ions Using Ion Flux Phenomena in Flow-Through Cl-ISEs with Ion Exchange Membranes

“…5 Also, to improve the sensitivity limits of potentiometric ISEs, various signal transduction approaches have been studied. 6 In general, ISEs with a low detection limit and high ion selectivity are desired. One way to lower the detection limit is to reduce transmembrane ion fluxes.…”

“…As for the sensing mode, sensing protocols other than zero-current potentiometry have also been used with ISEs, such as chronopotentiometry, chronoamperometry, and coulometry . Also, to improve the sensitivity limits of potentiometric ISEs, various signal transduction approaches have been studied …”