This paper investigates ionospheric response characteristics from multiple perspectives based on globally distributed GNSS data and products, ionosonde data, FORMOSAT-7/COSMIC-2 occultation data, and Swarm satellite observations caused by the total solar eclipse of 8 April 2024 across North and Central America. The results show that both GNSS-derived TEC products have detected the ionospheric TEC degradation triggered by the total solar eclipse, with the maximum degradation exceeding 10 TECU. The TEC data from nine GNSS stations in the path of the maximum eclipse reveal that the intensity of ionospheric TEC degradation is related to the spatial location, with the maximum degradation value of the ionospheric TEC being about 14~23 min behind the moment of the maximum eclipse. Additionally, a negative anomaly of foF2 with a maximum of more than 2.7 MHz is detected by ionosonde. In the eclipse region, NmF2 and hmF2 show trends of decrease and increase, with percentages of variation of 40~70% and 4~16%, respectively. The Ne profile of the Swarm-A satellite is significantly lower than the reference value during the eclipse period, with the maximum negative anomaly value reaching 11.2 × 105 el/cm3, and it failed to show the equatorial ionization anomaly.