Ionotropic Glutamate Receptors and Their Implications in Cancer and Therapeutics

Goyal, Shree; Chakraborty, Pallab

doi:10.2139/ssrn.3588139

Cited by 1 publication

(1 citation statement)

References 65 publications

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“…The ionotropic glutamate receptors (iGluRs) are ligand‐gated ion channels, which are divided into four groups based on structural similarities: NMDA receptors (NMDARs), AMPA receptors (AMPARs), kainate (KA) receptors (KARs), and delta receptors. 5 , 7 , 15 NMDARs consist of seven heterogeneous subunits: NR1, NR2A/B/C/D, and NR3A/B. 5 Whereas AMPARs are assembled from four subunits: GluR1/2/3/4, showing 70% of homology.…”

Section: Discussionmentioning

confidence: 99%

Genomics and transcriptomic alterations of the glutamate receptors in acute myeloid leukemia

Alqahtani,

Wang,

Lou

et al. 2023

Clinical Translational Sci

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Glutamine and glutamate have been widely explored as potential therapeutic targets in acute myeloid leukemia (AML). In addition to its bioenergetic role in leukemia cell proliferation, L‐glutamate is a neurotransmitter that acts on glutamate receptors. However, the role of glutamate receptors in AML is largely understudied. Here, we comprehensively analyze the genomic and transcriptomic alterations of glutamate receptor genes in AML using publicly available data. We investigated the frequency of mutations in the glutamate receptor genes and whether an association exist between the presence of these mutations and clinical and molecular characteristics or patient's clinical outcome. We also assessed the dysregulation of glutamate receptor gene expression in AML with and without mutations and whether gene dysregulation is associated with clinical outcomes. We found that 29 (14.5%) of 200 patients with AML had a mutation in at least one glutamate receptor gene. The DNMT3A mutations were significantly more frequent in patients with mutations in at least one glutamate receptor gene compared with patients without mutations (13 of 29 [44.8%] vs. 41 of 171 [23.9%], p value: 0.02). Notably, patients with mutations in at least one glutamate receptor gene survived shorter than patients without mutations; however, the results did not reach statistical significance (overall survival: 15.5 vs. 19.0 months; p value: 0.10). Mutations in the glutamate receptor genes were not associated with changes in gene expression and the transcriptomic levels of glutamate receptor genes were not associated with clinical outcome.

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