Ions Release from Ti Implant Alloys in Simulated Bioliquids

Prodana, Mariana; Caposi, M.; Iordǎchescu, Dana

doi:10.1007/978-3-540-69367-3_17

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…On the other hand, Ti-6Al-4V alloy revealed a release in Al ion after 7 days of exposure, increasing after 14 days. A similar result was previously reported by Prodana et al [ 83 ]. The authors reported ion release of all alloying elements, including Al, for shorter exposure times and decreased ion releases after 14 days.…”

Section: Resultssupporting

confidence: 92%

“…This phenomenon is expected because the α-Ti phase is rich in Al, preferably dissolved [ 84 , 85 , 86 ]. In this context, Chen et al [ 83 ] investigated Ti-6Al-4V exposed to simulated acidic solutions (pH 3 and 5), observing a preferential dissolution of the α-Ti over β-Ti by the optical surface profiler technique. It should also be mentioned that XPS (see Figure 6 ) revealed peaks related to Al 2 O 3 , indicating that Al can also be part of the passive film.…”

Section: Resultsmentioning

confidence: 99%

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A Tribological and Ion Released Research of Ti-Materials for Medical Devices

et al. 2021

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The increase in longevity worldwide has intensified the use of different types of prostheses for the human body, such as those used in dental work as well as in hip and knee replacements. Currently, Ti-6Al-4V is widely used as a joint implant due to its good mechanical properties and durability. However, studies have revealed that this alloy can release metal ions or particles harmful to human health. The mechanisms are not well understood yet and may involve wear and/or corrosion. Therefore, in this work, commercial pure titanium and a Ti-6Al-4V alloy were investigated before and after being exposed to a simulated biological fluid through tribological tests, surface analysis, and ionic dissolution characterization by ICP-AES. Before exposure, X-ray diffraction and optical microscopy revealed equiaxed α-Ti in both materials and β-Ti in Ti-6Al-4V. Scratch tests exhibited a lower coefficient of friction for Ti-6Al-4V alloy than commercially pure titanium. After exposure, X-ray photoelectron spectroscopy and surface-enhanced Raman spectroscopy results showed an oxide film formed by TiO2, both in commercially pure titanium and in Ti-6Al-4V, and by TiO and Al2O3 associated with the presence of the alloys. Furthermore, inductively coupled plasma atomic emission spectroscopy revealed that aluminum was the main ion released for Ti-6Al-4V, giving negligible values for the other metal ions.

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Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 99%

A Tribological and Ion Released Research of Ti-Materials for Medical Devices

et al. 2021

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“…This has resulted in high-strength, low-weight alloys with excellent corrosion resistance and biocompatibility 8 . Due to the relatively low cost and the good workability of the material, Ti6Al4V is the most widely-used alloy 25 .…”

Section: Introductionmentioning

confidence: 99%

Treatments for enhancing the biocompatibility of titanium implants

Štěpanovská¹,

Matějka²,

Rosina³

et al. 2020

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Titanium surface treatment is a crucial process for achieving sufficient osseointegration of an implant into the bone. If the implant does not heal sufficiently, serious complications may occur, e.g. infection, inflammation, aseptic loosening of the implant, or the stress-shielding effect, as a result of which the implant may need to be reoperated. After a titanium graft has been implanted, several interactions are crucial in order to create a strong bone-implant connection. It is essential that cells adhere to the surface of the implant. Surface roughness has a significant influence on cell adhesion, and also on improving and accelerating osseointegration. Other highly important factors are biocompatibility and resistance to bacterial contamination. Bio-inertness of titanium is ensured by the protective film of titanium oxides that forms spontaneously on its surface. This film prevents the penetration of metal compounds, and it is well-adhesive for calcium and phosphate ions, which are necessary for the formation of the mineralized bone structure. Since the presence of the film alone is not sufficient for the biocompatibility of titanium, a suitable surface finish is required to create a firm bone-implant connection. In this review, we explain and compare the most widely-used methods for modulating the surface roughness of titanium implants in order to enhance cell adhesion on the surface of the implant, e.g. plasma spraying, sandblasting, acid etching, laser treatment, sol-gel etc., The methods are divided into three overlapping groups, according to the type of modification. ) is gratefully acknowledged for his language revision of the manuscript. We also thank the Prospon s.r.o. company (Kladno, Czech Republic) for providing Ti6Al4V samples for studies on cell-material interaction.

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Are clinical findings of systemic titanium dispersion following implantation explained by available in vitro evidence? An evidence-based analysis

Curtin

Wang

2017

J Biol Inorg Chem

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Although the presence of titanium wear particles released into tissues is known to induce local inflammation following the therapeutic implantation of titanium devices into humans, the role that titanium ions play in adverse tissue responses has received little attention. Support that ongoing titanium ion release occurs is evidenced by the presence of ionic titanium bound to transferrin in blood, and ongoing excretion in the urine of patients with titanium devices. However, as reports documenting the presence of titanium within tissues do not distinguish between particulate and ionic forms due to technical challenges, the degree to which ionic titanium is released into tissues is unknown. To determine the potential for titanium ion release into tissues, this study evaluates available in vitro evidence relating to the release of ionic titanium under physiological conditions. This is a systematic literature review of studies reporting titanium ion release into solutions from titanium devices under conditions replicating the interstitial pH and constituents. Inclusion and exclusion criteria were defined. Of 452 articles identified, titanium ions were reported in nine media relevant to human biology in seventeen studies. Only one study, using human serum replicated both physiological pH and the concentration of constituents while reporting the presence of titanium ions. While there is insufficient information to explain the factors that contribute to the presence of titanium ions in serum of humans implanted with titanium devices, currently available information suggests that areas of future inquiry include the role of transferrin and organic acids.

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Ions Release from Ti Implant Alloys in Simulated Bioliquids

Cited by 3 publications

References 7 publications

A Tribological and Ion Released Research of Ti-Materials for Medical Devices

A Tribological and Ion Released Research of Ti-Materials for Medical Devices

Treatments for enhancing the biocompatibility of titanium implants

Are clinical findings of systemic titanium dispersion following implantation explained by available in vitro evidence? An evidence-based analysis

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