Iontophoresis, magnetophoresis, and electroporation

Ita, Kevin

doi:10.1016/b978-0-12-822550-9.00009-0

Cited by 2 publications

(2 citation statements)

References 146 publications

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“… 66 As the current release experiment shows that DEX release was faster than the expected enzymatic degradation, one can expect similar release rates regardless of the presence of the enzyme and its concentration. Moreover, as dexamethasone is a moderately lipophilic drug (log P 1.83), 67 it can be expected to readily diffuse to the release medium so that the potential contribution of the hydrolysis of the amphiphiles by the enzyme becomes even more limited. 68 Nevertheless, as eventual degradation of the amphiphiles can be a critical requirement to allow their clearance after releasing their cargo, we analyzed the degree of the degradation of the amphiphiles at the end of the release experiment.…”

Section: Resultsmentioning

confidence: 99%

Hydrogel Microneedles with Programmed Mesophase Transitions for Controlled Drug Delivery

Dawud,

Edelstein-Pardo,

Mulamukkil

et al. 2024

ACS Appl. Bio Mater.

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Microneedle-based drug delivery offers an attractive and minimally invasive administration route to deliver therapeutic agents through the skin by bypassing the stratum corneum, the main skin barrier. Recently, hydrogel-based microneedles have gained prominence for their exceptional ability to precisely control the release of their drug cargo. In this study, we investigated the feasibility of fabricating microneedles from triblock amphiphiles with linear poly(ethylene glycol) (PEG) as the hydrophilic middle block and two dendritic side-blocks with enzyme-cleavable hydrophobic end-groups. Due to the poor formation and brittleness of microneedles made from the neat amphiphile, we added a sodium alginate base layer and tested different polymeric excipients to enhance the mechanical strength of the microneedles. Following optimization, microneedles based on triblock amphiphiles were successfully fabricated and exhibited favorable insertion efficiency and low height reduction percentage when tested in Parafilm as a skin-simulant model. When tested against static forces ranging from 50 to 1000 g (4.9–98 mN/needle), the microneedles showed adequate mechanical strength with no fractures or broken segments. In buffer solution, the solid microneedles swelled into a hydrogel within about 30 s, followed by their rapid disintegration into small hydrogel particles. These hydrogel particles could undergo slow enzymatic degradation to soluble polymers. In vitro release study of dexamethasone (DEX), as a steroid model drug, showed first-order drug release, with 90% released within 6 days. Eventually, DEX-loaded MNs were subjected to an insertion test using chicken skin and showed full penetration. This study demonstrates the feasibility of programming hydrogel-forming microneedles to undergo several mesophase transitions and their potential application as a delivery system for self-administration, increased patient compliance, improved efficacy, and sustained drug release.

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Section: Resultsmentioning

confidence: 99%

Hydrogel Microneedles with Programmed Mesophase Transitions for Controlled Drug Delivery

Dawud,

Edelstein-Pardo,

Mulamukkil

et al. 2024

ACS Appl. Bio Mater.

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“…Andrographolide (Andro) (Figure 2), a diterpenoid lactone, is the main bioactive constituent of Andrographis paniculata, which possesses antibacterial, antiviral, anti-inflammatory and anti-cancer properties. It also has been considered as a promising molecule in developing anti-diabetic drugs [109,110]. The intact γ-butyrolactone ring, a hydroxyl group at C14, as well as double bonds between C12 and C13, and between C8 and C17 have been shown to be mainly responsible for Andro's cytotoxicity [111].…”

Section: Diterpenoids 241 Andrographolidementioning

confidence: 99%

Plant-Derived Terpenoids: A Promising Tool in the Fight against Melanoma

Kłos

Chlubek

2022

Cancers

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Melanoma is responsible for the highest number of skin cancer-caused deaths worldwide. Despite the numerous melanoma-treating options, the fight against it remains challenging, mainly due to its great heterogeneity and plasticity, as well as the high toxicity of standard drugs. Plant-derived terpenoids are a group of plant defense molecules that have been proven effective in killing many different types of cancer cells, both in in vitro experiments and in vivo models. In this review, we focus on recent results in the search for plant terpenoids with anti-melanoma activity. We also report on the synergistic action of combining terpenoids with other plant-derived substances, MAP kinase inhibitors, or radiation. Additionally, we present examples of terpenoid-loaded nanoparticle carriers as anti-melanoma agents that have increased permeation through the cancer tissue.

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Iontophoresis, magnetophoresis, and electroporation

Cited by 2 publications

References 146 publications

Hydrogel Microneedles with Programmed Mesophase Transitions for Controlled Drug Delivery

Hydrogel Microneedles with Programmed Mesophase Transitions for Controlled Drug Delivery

Plant-Derived Terpenoids: A Promising Tool in the Fight against Melanoma

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