Iontophoretic application of opiates to the locus coeruleus

Bird, Stephanie J.; Kuhar, Michael J.

doi:10.1016/0006-8993(77)90462-0

Cited by 286 publications

(52 citation statements)

References 37 publications

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“…80 Acute administration of levorphanol, an opioid receptor agonist, produced rapid suppression of LC firing. 81 Naloxone prevented and reversed the inhibitory effects of levorphanol, showing that opioid receptors are involved in this response. Morphine and clonidine, an α 2 -adrenoreceptor receptor agonist, each decreases LC firing in brain slices.…”

Section: Molecular Changes In the Locus Coeruleusmentioning

confidence: 92%

Molecular Changes in Opioid Addiction: The Role of Adenylyl Cyclase and cAMP/PKA System

Chan

Lutfy

2016

Progress in Molecular Biology and Translational Science

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Section: Molecular Changes In the Locus Coeruleusmentioning

confidence: 92%

Molecular Changes in Opioid Addiction: The Role of Adenylyl Cyclase and cAMP/PKA System

Chan

Lutfy

2016

Progress in Molecular Biology and Translational Science

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“…They may represent sampling differences from heterogeneous areas (e.g. see Bird & Kuhar, 1977) or species differences (e.g. see Gent & Wolstencroft, 1976;Anderson, Lobataz & Proudfit, 1977).…”

Section: Discussionmentioning

confidence: 99%

Pharmacological and Electrophysiological Studies of Morphine and Enkephalin on Rat Supraspinal Neurones and Cat Spinal Neurones

Davies

Dray

1978

British J Pharmacology

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1 The actions of morphine, methionine and leucine enkephalin, administered electrophoretically, were studied on supraspinal neurones in the cortex and brainstem of the rat anaesthetized with urethane and on spinal Renshaw cells and dorsal horn interneurones in the cat anaesthetized with pentobarbitone. 2 The majority of Renshaw cells and cortical and brainstem neurones were excited by all three compounds although some supraspinal neurones were depressed. 3 Naloxone reversibly antagonized both excitatory and depressant actions of morphine and enkephalin. Acetylcholine-induced excitation but not amino acid-induced excitation was also antagonized by naloxone. 4 Neither morphine nor the enkephalins had any naloxone-reversible action on dorsal horn neurones when ejected from conventional multibarrelled electrodes. However, morphine but not enkephalin, administered into the substantia gelatinosa region of the spinal cord selectively reduced responses to noxious stimuli of neurones in deeper laminae. Naloxone administered into the same region antagonized this action of morphine. 5 Intravenous morphine also antagonized responses of dorsal horn neurones to noxious stimuli and subsequent intravenous naloxone reversed this effect. 6 It was concluded that the excitatory and inhibitory effects of morphine and enkephalin on central neurones may be mediated by actions on different opiate receptors and that depression of noxious responses of dorsal horn neurones may be relevant to the analgesic action of morphine.

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“…Cells in the locus coeruleus respond to noxious stimuli by excitation and to morphine by inhibition (Korf et al 1974;Bird & Kuhar, 1977) and locus coeruleus lesion reduces morphine analgesia (Sasa, Munekiyo, Osumi & Takaori, 1977). The present study was therefore undertaken to investigate the connexion between the dorsal raphe and cells of the locus coeruleus in the rat, in an attempt to clarify the possible interaction between serotonin, noradrenaline, and the endogenous morphinelike peptides in the brain.…”

Section: Introductionmentioning

confidence: 99%

Serotonergic innervation of the locus coeruleus from the dorsal raphe and its action on responses to noxious stimuli.

Segal¹

1979

The Journal of Physiology

243

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SUMMARYThe connexions between the dorsal raphe nucleus and the nucleus locus coeruleus were studied in urethane anaesthetized rats.1. (Cells in the locus coeruleus gave an excitatory response to a noxious stimulus, e.g. leg pinch.2. This excitatory response was blocked by either a parenteral or an ionophoretic injection of morphine and recovered after an injection of naloxone.3. Electrical stimulation in the region of the dorsal raphe blocked excitatory locus coeruleus responses to noxious stimuli.4. While naloxone did not antagonize the effects of the dorsal raphe stimulation towards locus coeruleus activity, these effects were absent in rats pretreated with a serotonin synthesis inhibitor, PCPA or with 5,7-DHT which destroys serotonincontaining terminals, and were reduced by the serotonin antagonist methysergide.5. A serotonin-containing inhibitory pathway between the dorsal raphe and the locus coeruleus is proposed to account for these results.

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Iontophoretic application of opiates to the locus coeruleus

Cited by 286 publications

References 37 publications

Molecular Changes in Opioid Addiction: The Role of Adenylyl Cyclase and cAMP/PKA System

Molecular Changes in Opioid Addiction: The Role of Adenylyl Cyclase and cAMP/PKA System

Pharmacological and Electrophysiological Studies of Morphine and Enkephalin on Rat Supraspinal Neurones and Cat Spinal Neurones

Serotonergic innervation of the locus coeruleus from the dorsal raphe and its action on responses to noxious stimuli.

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