Iopamidol, a new non-ionic hydrosoluble contrast medium for neuroradiology

Hammer, B; Lackner, W.

doi:10.1007/bf00342385

Cited by 47 publications

(4 citation statements)

References 3 publications

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“…The advent of c omputed tomograph y (CT) and th e use of new water-so lu ble contrast media suc h as metrizami de [1] and lopamid ol [ 2] provide a new mode of investigatio n. Metrizamide co mputed tomog raphi c cistern og raphy (MCTC) was first used in 1977 by Drayer et al [3] and by one of us [4] to demonstrate CSF rhin o rrh ea. Since th en , iso lated cases [5 -10] o r short se ries [11 , 1 2] have been reported c onfirmin g the utility of thi s method.…”

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confidence: 99%

Cerebrospinal fluid rhinorrhea: evaluation with metrizamide cisternography

Manelfe¹,

P²,

Sobel³

et al. 1982

American Journal of Roentgenology

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Metrizamide computed tomog r aphic cist ernography was used to e xamin e 27 pat ient s (19 males and eight f emales , 14-59 years old) clinicall y suspected o f having ce rebrospinal f luid fist ulae with rhinorrhea. Twenty-one fi stulae were t rau matic and si x w ere spontaneous. Five t o 6 ml of metrizam ide (or lopamidol , t wo cases) were inject ed by lumbar puncture at a concentra t ion of 185-200 mg I/ ml f or direct corona l and ax ial computed tomographic sections o f the skull base. Cerebrospin al fluid rhinorrh ea w as p resent at the time of e xamination in 12 of 27 cases. Results were evalu ated according to three criteria: (1) metrizamide passage th rough t he bony and dural def ect; (2) demonstrable site of t he fracture and / or bony defect; and (3) metrizamide vi sualized within a paranasal sinus, nasal cavity, or cotton p ledget. T he e xam inat ion was considered positive when criterion 1 alone was present and when 2 and 3 we re associated. In 15 o f 27 cases, cisternography was posit ive, wit h t he e xact site of cerebrospinal f luid leakage demonstrated in 10 patients. In si x cases, t he result s were not defi nitive; only one of the criteria (2 or 3) was fulfilled. In si x cases, cisternog raphy w as normal. Seventeen patients underwent surgery. The site of cerebrospinal f ist ulae w as et hmoidal in nine cases, frontoet hmoidal in seven , sphenoidal in t wo, and sphenoethmoidal in one. The relative value of metrizamide computed tomographic cist ernography compared with ot her diagnostic st udies, poly tomography, positive or negative contrast studies, and radionuclides , is discussed. Diagnost ic pitfalls include art ifacts and partia l volume effect.

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confidence: 99%

Cerebrospinal fluid rhinorrhea: evaluation with metrizamide cisternography

Manelfe¹,

P²,

Sobel³

et al. 1982

American Journal of Roentgenology

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“…Paraplegia has been described in the literature with iopamidol and iohexol dye formulations, and this occurs immediately after the infusion of the dye (7,9). Unlike patients with reactions to older dye formulations such as metrizamide, most patients with reactions to iopamidol recover rapidly without any neurological sequelae, as seen in this case (2,4).…”

Section: Discussionmentioning

confidence: 86%

“…The use of nonionic contrast media for radiological procedures has led to a significant decrease in allergic reactions during these tests. Iopamidol, a nonionic, water-soluble contrast medium, is often used for CT myelograms because of its nontoxic profile (2). Despite the use of nonionic contrast media to decrease toxicities, rare case reports have identified adverse reactions such as seizures, inappropriate antidiuretic hormone (ADH) secretion, meningoencephalitis, meningoencephalopathy, and paraplegia (3)(4)(5)(6)(7)(8)(9).…”

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Iopamidol-Induced Meningoencephalopathy in an Hiv-Seropositive Patient

Stroup¹,

Stephens²,

Baker³

2007

Baylor University Medical Center Proceedings

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Central nervous system infectious and metabolic abnormalities are common in HIV-positive patients. Drug therapy, opportunistic infections, the clinical course of HIV disease itself, and very rarely iodinated radiographic contrast agents can all be linked to these abnormalities. The following case describes an HIV-seropositive patient who developed encephalopathy after undergoing a cervical myelogram that utilized iopamidol dye (Isovue-M 300 mg/mL).

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“…for example, Iohexol (Nycgaard) which is now in preclinical trials in Scandi navian countries. Another new CM, Iopamidol (Bracco), has been used for 2 years in some clinics in Italy and tested with good results by Hammer and Lackner [5], One of the advantages of Iopamidol is that this non ionic CM is presented as a stable solution containing 200 mg iodine/ml. We have re cently performed 30 radiculographies with iopamidol without any adverse reactions.…”

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confidence: 99%

The Contrast Media Used for Myelography

Chrzanowski¹

1982

Eur Neurol

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A review of the contrast media used for myelography and radiculography is presented. Water-soluble, nonionic medium like metrizamide enables the examination of the entire CSF space. The relation of the diagnostic benefit to complications when using this contrast medium is favorable. Attention must be paid in using the correct myelographic technique and in controlling the possible severe adverse reactions which appear in 1.5% of the cases during 24 h after the examination.

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Iopamidol, a new non-ionic hydrosoluble contrast medium for neuroradiology

Abstract: The side effects associated with the use of Iopamidol for myelography were determined in 100 patients and compared with metrizamide in a double-blind study.

Cited by 47 publications

References 3 publications

Cerebrospinal fluid rhinorrhea: evaluation with metrizamide cisternography

Cerebrospinal fluid rhinorrhea: evaluation with metrizamide cisternography

Iopamidol-Induced Meningoencephalopathy in an Hiv-Seropositive Patient

The Contrast Media Used for Myelography

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