Iopamidol, a new nonionic contrast medium in peripheral angiography

Kallehauge, H. E.; Praestholm, J

doi:10.1007/bf02552806

Cardiovasc Intervent Radiol

1982

DOI: 10.1007/bf02552806

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Iopamidol, a new nonionic contrast medium in peripheral angiography

H. E. Kallehauge

J Praestholm

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Cited by 2 publications

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References 7 publications

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“…2-Amino-1,3-propanediol (2-APD, also known as serinol) is a high-value-added chemical that is used as a building block for the synthesis of a variety of compounds, including drugs to treat type 2 diabetes mellitus, 1 immune multiple sclerosis, 2 the antibiotic chloramphenicol, 3 and a new generation of nonionic X-ray contrast agents 4 (Figure 1A). 2-APD is currently produced by chemical processes; however, these processes have several disadvantages, including the use of highly explosive starting materials (e.g., nitromethane and 2-nitro-1,3-propanediol) (Figure 1B), expensive reductive reagents, and high-pressure equipment.…”

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confidence: 99%

An Artificial Biosynthetic Pathway for 2-Amino-1,3-Propanediol Production Using Metabolically Engineered Escherichia coli

et al. 2019

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2-Amino-1,3-propanediol (2-APD) is a chemical building block for the production of various value-added pharmaceuticals. However, the current manufacture of 2-APD predominantly relies on chemical processes by utilizing fossil fuel-derived and highly explosive raw materials. Herein, we established an artificial biosynthetic pathway for converting glucose to 2-APD in a metabolically engineered Escherichia coli. This artificial pathway employs an engineered heterogeneous aminotransferase RtxA for diverting dihydroxyacetone phosphate to generate 2-APD phosphate and an endogenous phosphatase for converting it into the target product 2-APD. Through fine-tuning the activity and solubility of RtxA for efficiently extending the glycolysis pathway, enhancing the metabolic recycling of amino-containing substrate supply via nitrogen-borrowing, and unlocking the dephosphorylation involved in the downstream pathway, the best metabolically engineered E. coli strain LYC-5 was constructed stepwise. Under aerobic conditions, a fed-batch fermentation of the strain LYC-5 produced 14.6 g/L 2-APD with a productivity of 0.122 g/L/h in a 6-L bioreactor, which was the highest reported titer to the best of our knowledge. This work demonstrates the great potential to provide an environmentally friendly and efficient approach for 2-APD production.

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confidence: 99%

An Artificial Biosynthetic Pathway for 2-Amino-1,3-Propanediol Production Using Metabolically Engineered Escherichia coli

et al. 2019

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In vitro study on the anticoagulant effect of the water soluble contrast material: diatrizoate, ioxaglate and iopromide

Lim¹,

Chin²,

Kim³

et al. 1989

J Korean Radiol Soc

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It has been reported that new1y deve10ped noni onic contrast materia1 is 1ess effective in anticoagu1 ati on than lO ni c contrast media. Anticoagu1 ati on pro perties were studied with hig h osmo1ar ioni c contrast medium(di atrizoate) , 10w osmo1ar ioni c medium(ioxag1ate) and 10w 。 s m o 1 ar nonioni c contras t medium(iopromide) as well as with norm a1 saline for contro1Arteri a1 b100d was taken from 10 adults befo re angiograph y. T wo ml. of the arteri a1 b100d was introduced into the p1asti c syringes containing 2 cc. of each contras t medium and sa1ine. The syringes were ke pt undisturbed in room temp erature for 10 minutes, 30 miutes, 60 minutes 90 minutes and th e n the b1ood -contrast mixttire was po ured o n the fi1ter paper to de tect th e clots formed in the syringes. De1ay of the clotting time was a1so checked in the contras t media with various concentraions of 100 %, 30 %, 10 %, and 3 %. Chi-square test of the data shows very signifi cant diffe ren ce in antico-agu1 ati on effect betwee n the ioni c gro up(diatrizo ate , ioxag 1ate) and the nonionic one(iopromide). C10tting time in the noni onic medium(iopromide) was shorter in 30 % concentration than th at of the lO (l ic materi a1(diatrizoate, ioxag1 ate). N oni oni c contras t medium(iopromide) has anti coagu1 ation effect, bu t 1ess effective th an io ni c medi a(d iatrizoate, ioxag1ate)

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Iopamidol, a new nonionic contrast medium in peripheral angiography

Cited by 2 publications

References 7 publications

An Artificial Biosynthetic Pathway for 2-Amino-1,3-Propanediol Production Using Metabolically Engineered Escherichia coli

An Artificial Biosynthetic Pathway for 2-Amino-1,3-Propanediol Production Using Metabolically Engineered Escherichia coli

In vitro study on the anticoagulant effect of the water soluble contrast material: diatrizoate, ioxaglate and iopromide

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