Recently, there has been an evolution toward a science-supported medicine, which uses replicable results from comprehensive studies to assist clinical decision-making. Reliable techniques are required to improve the consistency and replicability of studies assessing the effectiveness of clinical guidelines, mostly in muscular and therapeutic healthcare. In scientific research, surface electromyography (sEMG) is prevalent but underutilized as a valuable tool for physical medicine and rehabilitation. Other electrophysiological signals (e.g., from electrocardiogram (ECG), electroencephalogram (EEG), and needle EMG) are regularly monitored by medical specialists; nevertheless, the sEMG technique has not yet been effectively implemented in practical medical settings. However, sEMG has considerable clinical promise in evaluating muscle condition and operation; nevertheless, precise data extraction requires the definition of the procedures for tracking and interpreting sEMG and understanding the fundamental biophysics. This review is centered around the application of sEMG in rehabilitation and health monitoring systems, evaluating their technical specifications, including wearability. At first, this study examines methods and systems for tele-rehabilitation applications (i.e., neuromuscular, post-stroke, and sports) based on detecting EMG signals. Then, the fundamentals of EMG signal processing techniques and architectures commonly used to acquire and elaborate EMG signals are discussed. Afterward, a comprehensive and updated survey of wearable devices for sEMG detection, both reported in the scientific literature and on the market, is provided, mainly applied in rehabilitation training and physiological tracking. Discussions and comparisons about the examined solutions are presented to emphasize how rehabilitation professionals can reap the aid of neurobiological detection systems and identify perspectives in this field. These analyses contribute to identifying the key requirements of the next generation of wearable or portable sEMG devices employed in the healthcare field.
