IP-10 is highly involved in HIV infection

Lei, Jie; Yin, Xu; Shang, Hong; Jiang, Yongjun

doi:10.1016/j.cyto.2018.11.018

Cited by 83 publications

(76 citation statements)

References 94 publications

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“…Additionally, JHS and REGARDS do not have data on viral titers or self-reported diagnoses for common chronic viral infections such as HBV and HCV. IP-10 has been correlated with chronic viral infection in previous studies [63,64] but we were not able to examine this. Future work should further examine cause of death in larger samples in order to better understand why IP-10 is associated with overall mortality and explore suggestive associations with risk of cancer mortality.…”

Section: Plos Onementioning

confidence: 73%

Interferon gamma-induced protein 10 (IP-10) and cardiovascular disease in African Americans

et al. 2020

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Biomarkers of chronic inflammation (such as C-reactive protein) have long been associated with cardiovascular disease and mortality; however, biomarkers involved in antiviral cytokine induction and adaptive immune system activation remain largely unexamined. We hypothesized the cytokine interferon gamma inducible protein 10 (IP-10) would be associated with clinical and subclinical cardiovascular disease and all-cause mortality in African Americans. We assessed these associations in the Jackson Heart Study (JHS) cohort and the REasons for Geographic and Racial Differences in Stroke (REGARDS) study. There was a modest association of IP-10 with higher odds of left ventricular hypertrophy (OR = 1.20 (95% confidence interval (CI) 1.03, 1.41) per standard deviation (SD) higher natural log-transformed IP-10 in JHS). We did not observe associations with ankle brachial index, intima-media thickness, or arterial calcification. Each SD higher increment of ln-transformed IP-10 concentration was associated with incident heart failure (hazard ratio (HR) 1.26; 95%

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Section: Plos Onementioning

confidence: 73%

Interferon gamma-induced protein 10 (IP-10) and cardiovascular disease in African Americans

et al. 2020

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“…In contrast, an ‘unmasking IRIS’ or HIV-IRIS is an immune response against a pathogen that has not caused any obvious clinical disease before the initiation of ART [ 29 ]. IP-10 plays an important role in HIV infection and is associated with disease progression [ 22 ]. In PR or TB-IRIS, a cytokine release syndrome is suspected to be the underlying mechanism [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Plasma interferon-γ-inducible protein 10 (IP-10) levels correlate with disease severity and paradoxical reactions in extrapulmonary tuberculosis

et al. 2020

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Background With 1.5 million deaths worldwide in 2018, tuberculosis (TB) remains a major global public health problem. While pulmonary TB (PTB) is the most common manifestation, the proportion of extrapulmonary TB (EPTB) is increasing in low-burden countries. EPTB is a heterogeneous disease entity posing diagnostic and management challenges due to the lack of reliable biomarkers. In this study, we prospectively evaluated clinical data and treatment response which were correlated with different biomarkers. Methods The study was conducted at the University Hospital of Cologne. 20 patients with EPTB were enrolled. We analyzed plasma interferon-γ-inducible protein 10 (IP-10) levels in plasma by ELISA for up to 12 months of treatment. In addition, the QuantiFERON ® -TB Gold Plus (QFT ® Plus) test was performed during the course of treatment. Clinical data were assessed prospectively and correlated with QFT ® Plus and IP-10 levels. Results Plasma IP-10 levels were found to be significantly increased ( p < 0.001) in patients with extensive disease compared to patients with limited disease (cervical lymph node TB) or healthy controls. In patients with clinically confirmed paradoxical reaction (PR), a further increase of IP-10 was noted. IFN-γ measured by the QFT ® Plus test did not decrease significantly during the course of treatment. Of note, in four EPTB patients (20%) without radiographic pulmonary involvement, sputum culture was positive for Mycobacterium tuberculosis . Conclusion Our data demonstrate that IP-10 may be a valuable biomarker for estimation of disease severity in EPTB and monitoring of the disease course in extensive forms. However, IP-10 may be less suitable for diagnosis and monitoring of EPTB patients with limited disease. The QFT ® Plus test does not appear to be a suitable marker for therapy monitoring. Sputum should be examined in EPTB patients even in case of normal diagnostic imaging of the chest. Supplementary information is available for this paper at 10.1007/s15010-020-01541-1.

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“…response, chemotaxis, tumor proliferation, and enhancing and/or suppressing cancer-associated inflammation [18][19][20][21][22]. There was no statistically significant difference between the two groups at baseline or at DAR in the plasma levels of VEGF, TGF-β, TNF, and IL-10.…”

Section: Plos Onementioning

confidence: 94%

“…IP-10 is a chemoattractant for recruiting leukocytes to involved tissues, and thereby intensifies inflammation that results in tissue damage [39,40]. It is also closely associated with HIV infection, systemic inflammation, and cellular activation [19]. In cancer, IP-10 has been shown to both inhibit and promote tumor formation and/or metastasis [20].…”

Section: Plos Onementioning

confidence: 99%

Outcome markers of ART-treated HIV+ patients with early stage Kaposi’s sarcoma

et al. 2020

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HIV-associated/epidemic Kaposi's sarcoma (EpKS) is an AIDS-defining angio-proliferative malignancy. It can be treated with antiretroviral therapy (ART) alone or with ART plus cytotoxic chemotherapy. ART-treated EpKS can either respond or worsen upon treatment. This study aimed at identifying immunological markers of ART-treatment response. We compared responders (those with clinical EpKS tumor regression) versus poor responders (those with progressive or non-responsive EpKS). We measured plasma cytokine and chemokine levels using cytometric bead assays. Kaposi's sarcoma herpesvirus (KSHV) neutralizing antibody (nAb) responses were also quantified to test associations with treatment outcome. Interleukin (IL)-5 levels were significantly elevated in responders versus poorresponders at baseline (0.76pg/ml vs. 0.37pg/ml; p<0.01) and follow-up (0.56pg/ml vs. 0.37pg/ml; p<0.01); IL-6 was lower in responders than poor-responders at follow-up (600fg/ ml vs. 4272fg/ml; p<0.05). IP-10/CxCL-10 was significantly lower at follow-up in responders versus poor-responders (187pg/ml vs. 528pg/ml; p<0.01). KSHV nAb were not significantly differential between responders and poor-responders. In conclusion, high plasma IL-5 at baseline could be a marker for ART-treated KS tumor regression, whereas increased proinflammatory cytokine IL-6, and the chemokine IP-10, associate with KS tumor progression.

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IP-10 is highly involved in HIV infection

Cited by 83 publications

References 94 publications

Interferon gamma-induced protein 10 (IP-10) and cardiovascular disease in African Americans

Interferon gamma-induced protein 10 (IP-10) and cardiovascular disease in African Americans

Plasma interferon-γ-inducible protein 10 (IP-10) levels correlate with disease severity and paradoxical reactions in extrapulmonary tuberculosis

Outcome markers of ART-treated HIV+ patients with early stage Kaposi’s sarcoma

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