IPP5 inhibits neurite growth in primary sensory neurons by maintaining TGF- /Smad signaling

Han, Qingjian; Gao, Nannan; Guo-QiangMa,; Zhang, Zhenning; Yu, Wenhui; Pan, Jing; Wang, Qiong; Zhang, Xu; Liu, Bao

doi:10.1242/jcs.114280

Cited by 13 publications

(13 citation statements)

References 47 publications

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“…PDE1A is a Ca2+/calmodulin dependent cyclic nucleotide phosphodiesterase (PDEls) that regulates cAMP and cGMP 67 and can regulate L-type and T-type voltage gated calcium channels 68 . PPP1R1C has been shown to regulate neurite growth in cultured neurons 69 and is an inhibitor of protein phosphatase 1 (PP1), a protein involved in synaptic transmission and plasticity as part of the post synaptic density 70 . Locus 2 is indexed by an uncommon SNP (minor allele frequency = 0.018) and covers a broad, gene dense region implicating 53 diverse genes (Supplementary Figure 15–16).…”

Section: Resultsmentioning

confidence: 99%

A genome-wide association study for shared risk across major psychiatric disorders in a nation-wide birth cohort implicates fetal neurodevelopment as a key mediator

Schork

Won

Appadurai

et al. 2017

Preprint

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There is mounting evidence that seemingly diverse psychiatric disorders share genetic etiology, but the biological substrates mediating this overlap are not well characterized. Here, we leverage the unique iPSYCH study, a nationally representative cohort ascertained through clinical psychiatric diagnoses indicated in Danish national health registers. We confirm previous reports of individual and cross-disorder SNP-heritability for major psychiatric disorders and perform a cross-disorder genome-wide association study. We identify four novel genome-wide significant loci encompassing variants predicted to regulate genes expressed in radial glia and interneurons in the developing neocortex during midgestation. This epoch is supported by partitioning cross-disorder SNP-heritability which is enriched at regulatory chromatin active during fetal neurodevelopment. These findings indicate that dysregulation of genes that direct neurodevelopment by common genetic variants results in general liability for many later psychiatric outcomes.

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Section: Resultsmentioning

confidence: 99%

A genome-wide association study for shared risk across major psychiatric disorders in a nation-wide birth cohort implicates fetal neurodevelopment as a key mediator

Schork

Won

Appadurai

et al. 2017

Preprint

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“…Sensory DRG neurons express EGF receptor [ 47 ] and it has been shown that TGFα induces sensory activation [ 48 ] and neuronal growth [ 49 ], where as EGF does not [ 49 ]. Furthermore, additional growth factors TGFβ inhibits neuronal growth [ 50 ] and GM-CSF stimulates neurogenesis and bone cancer pain [ 15 ]. These alternative factors such as GM-CSF can differ between these pathologically distinct breat cancer cell lines such as in comparing basal like MDA MB231 and luminal A MCF7 with distinct GM-CSF derived actions demonstrated in MDA MB231 [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Breast cancer induced nociceptor aberrant growth and collateral sensory axonal branching

et al. 2017

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The tumour and neuron interaction has a significant impact upon disease progression and the patients quality of life. In breast cancer patients, it is known that there is an interaction between the tumour microenvironment and the sensory neurons to influence the progression of cancer as well as pain, though these mechanisms still need to be clearly defined. Here it is demonstrated that in a rodent orthotopic model of breast cancer (MDA MB 231) there was an increase in nerve fibre innervation into the tumour microenvironment (protein gene product 9.5), which were calcitonin gene related peptide positive C fibre nociceptors. In contrast, there was a reduction in myelinated nerve fibres (NF200). A sensory neuronal cell line was cultured in response to conditioned media from MDA MB231 and MCF7 as well as vascular endothelial growth factor-A (VEGF-A). All these experimental conditions induced sensory neuronal growth, with increased formation of collateral axonal branches. Furthermore, it was demonstrated that MDA MB231 and VEGF-A induced sensory neuronal sensitisation in response to capsaicin a TRPV1 agonist. MDA MB231 induced neuronal growth was suppressed by VEGFR2 inhibition (ZM323881 and neutralising antibody DC101), in addition both MDA MB231 and VEGF-A induced neurite growth was attenuated by the inhibition of ARP2/3 complex through co-treatment with CK666. This demonstrates that breast cancer can interact with the sensory nervous system to drive neuritogenesis through a VEGF-A/VEGFR2/ARP2/3 mediated pathway.

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“…It may also act by upregulating the synthesis and release of β-FGF in the anterior horn motor neurons of the spinal cord during regeneration [279] and other neurotrophic factors. However, not all experiments with TGF-beta have found that it induces enhanced axon regeneration [323].…”

Section: Platelet-released Factorsmentioning

confidence: 99%

Platelet-Rich Plasma Promotes Axon Regeneration, Wound Healing, and Pain Reduction: Fact or Fiction

Kuffler

2015

Mol Neurobiol

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Platelet-rich plasma (PRP) has been tested in vitro, in animal models, and clinically for its efficacy in enhancing the rate of wound healing, reducing pain associated with injuries, and promoting axon regeneration. Although extensive data indicate that PRP-released factors induce these effects, the claims are often weakened because many studies were not rigorous or controlled, the data were limited, and other studies yielded contrary results. Critical to assessing whether PRP is effective are the large number of variables in these studies, including the method of PRP preparation, which influences the composition of PRP; type of application; type of wounds; target tissues; and diverse animal models and clinical studies. All these variables raise the question of whether one can anticipate consistent influences and raise the possibility that most of the results are correct under the circumstances where PRP was tested. This review examines evidence on the potential influences of PRP and whether PRP-released factors could induce the reported influences and concludes that the preponderance of evidence suggests that PRP has the capacity to induce all the claimed influences, although this position cannot be definitively argued. Well-defined and rigorously controlled studies of the potential influences of PRP are required in which PRP is isolated and applied using consistent techniques, protocols, and models. Finally, it is concluded that, because of the purported benefits of PRP administration and the lack of adverse events, further animal and clinical studies should be performed to explore the potential influences of PRP.

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IPP5 inhibits neurite growth in primary sensory neurons by maintaining TGF- /Smad signaling

Cited by 13 publications

References 47 publications

A genome-wide association study for shared risk across major psychiatric disorders in a nation-wide birth cohort implicates fetal neurodevelopment as a key mediator

A genome-wide association study for shared risk across major psychiatric disorders in a nation-wide birth cohort implicates fetal neurodevelopment as a key mediator

Breast cancer induced nociceptor aberrant growth and collateral sensory axonal branching

Platelet-Rich Plasma Promotes Axon Regeneration, Wound Healing, and Pain Reduction: Fact or Fiction

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