Ipratropium Bromide Added to Asthma Treatment in the Pediatric Emergency Department

Abstract

The addition of three doses of ipratropium to an ED treatment protocol for acute asthma was associated with reductions in duration and amount of treatment before discharge.

Comparison of levalbuterol and racemic albuterol combined with ipratropium bromide in acute pediatric asthma: A randomized controlled trial

“…It was expected that LOS data would be skewed, so a sample size calculation was made with a non-parametric adjustment allowing for unequal variances in both LEV and RAC/IB groups. Assuming standard deviations of 50 and 60 min, and a two-sided alpha error rate of 5%, 70 subjects per treatment group (140 subjects total) provided 80% power to detect a 25 minute difference in ED LOS (4).…”

Anticholinergics/Antimuscarinic Drugs in Asthma

“…It is, however, effective when added to a SABA in the context of severe exacerbations [4••, [51][52][53]. Treatment with inhaled ipratropium combined with albuterol in the emergency room reduced hospital admissions and improved lung function, particularly in patients with FEV 1 <30 %, and symptoms for more than 1 day [54,55]. Although other studies have concluded that did not reduce the length of hospitalization or admission to intensive care unit [56], a Cochrane Review concluded that nebulized ipratropium combination with a SABA significantly reduces the risk of hospital admission and other had other clinically important outcomes [57].…”

Por que a criança com obstrução grave da via aérea atendida no pronto socorro é diferente

“…to inicial da criança 2 inclui a utilização de beta-2-agonistas, agentes anticolinérgicos (brometo de ipratrópio) [3][4][5][6][7][8] , administrados em conjunto com os beta-2-agonistas e corticói-des por via sistêmica 9. Entretanto, o papel de outras drogas no tratamento inicial da asma aguda ainda não está totalmente esclarecido.…”