2021
DOI: 10.1007/s11356-021-14339-x
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Iprodione and/or chlorpyrifos exposure induced testicular toxicity in adult rats by suppression of steroidogenic genes and SIRT1/TERT/PGC-1α pathway

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Cited by 14 publications
(7 citation statements)
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“…62) Abd-Elhakim et al demonstrated chlorpyrifos (CPF) induced reprotoxic effect could be related to the modulation of NR5A1, HSD17B3, and SIRT1/TERT/PGC-1α pathway in the testicular tissue. 63) However, the molecular mechanism of soman induced PGC-1α has not been reported. In the present study, we observed a remarkable reduction of PGC-1α protein.…”
Section: Discussionmentioning
confidence: 99%
“…62) Abd-Elhakim et al demonstrated chlorpyrifos (CPF) induced reprotoxic effect could be related to the modulation of NR5A1, HSD17B3, and SIRT1/TERT/PGC-1α pathway in the testicular tissue. 63) However, the molecular mechanism of soman induced PGC-1α has not been reported. In the present study, we observed a remarkable reduction of PGC-1α protein.…”
Section: Discussionmentioning
confidence: 99%
“…Testicular steroidogenesis is a regulated multistep process controlled by multiple genes [95,96]. TES is produced chiefly in Leydig cells through a series of enzymatic reactions.…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, CPS residues are usually detected in citrus fruits, apples, bananas, and pears [ 9 ]. Many adverse effects were caused by CPS exposure, such as neurotoxicity [ 12 ], nephrotoxicity [ 13 ], developmental toxicity [ 14 ], reprotoxicity [ 15 , 16 ], endocrine disruption [ 17 ], and hepatotoxicity [ 18 , 19 ].…”
Section: Introductionmentioning
confidence: 99%
“…Indeed, among 23 pesticides tested for residual detection in fruit products, IPD was shown to be the most prevalent [ 39 ]. In some experimental models, IPD showed endocrine disruption [ 40 , 41 ], cardiotoxicity [ 42 ], and reprotoxicity [ 15 , 16 ]. Nonetheless, the evidence on IPD toxicity is still inadequate and does not allow for risk assessments [ 43 ].…”
Section: Introductionmentioning
confidence: 99%