Ipsilateral resistance exercise prevents exercise-induced central sensitization in the contralateral limb: a randomized controlled trial

Hosseinzadeh, Mahdi; Samani, Afshin; Andersen, Ole Kæseler; Nosaka, Kazunori; Arendt-Nielsen, Lars; Madeleine, Pascal

doi:10.1007/s00421-015-3205-x

Cited by 15 publications

(15 citation statements)

References 47 publications

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“…It has been demonstrated that in lower limb muscles, an initial bout of eccentric exercise mediates the hyperexcitability of the spinal nociceptive pathways that elicit a decreased central sensitization during the repeated bout . This central sensitization seems to be independent from altered contractile properties since it can be elicited by contralateral exercise, and may be related with a lower perception of soreness in the RBE. Moreover, it seems that connective tissue damage and inflammation are more responsible for the soreness than muscle fiber damage and inflammation .…”

Section: Discussionmentioning

confidence: 99%

The repeated bout effect can occur without mechanical and neuromuscular changes after a bout of eccentric exercise

Pincheira

Hoffman

Cresswell

et al. 2018

Scandinavian Med Sci Sports

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Changes in muscle fascicle mechanics have been postulated to underpin the repeated bout effect (RBE) observed following exercise-induced muscle damage (EIMD). However, in the medial gastrocnemius (MG), mixed evidence exists on whether fascicle stretch amplitude influences the level of EIMD, thus questioning whether changes in fascicle mechanics underpin the RBE. An alternative hypothesis is that neural adaptations contribute to the RBE in this muscle. The aim of this study was to investigate the neuromechanical adaptations during and after repeated bouts of a highly controlled muscle lengthening exercise that aimed to maximize EIMD in MG. In all, 20 subjects performed two bouts of 500 active lengthening contractions (70% of maximal activation) of the triceps surae, separated by 7 days. Ultrasound constructed fascicle length-torque (L-T) curves of MG, surface electromyography (EMG), maximum torque production, and muscle soreness were assessed before, 2 hours and 2 days after each exercise bout. The drop in maximum torque (4%) and the increase in muscle soreness (24%) following the repeated bout were significantly less than following the initial bout (8% and 59%, respectively), indicating a RBE. However, neither shift in the L-T curve nor changes in EMG parameters were present. Furthermore, muscle properties during the exercise were not related to the EIMD or RBE. Our results show that there are no global changes in gastrocnemius mechanical behavior or neural activation that could explain the observed RBE in this muscle. We suggest that adaptations in the non-contractile elements of the muscle are likely to explain the RBE in the triceps surae.

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Section: Discussionmentioning

confidence: 99%

The repeated bout effect can occur without mechanical and neuromuscular changes after a bout of eccentric exercise

Pincheira

Hoffman

Cresswell

et al. 2018

Scandinavian Med Sci Sports

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“…All these diseases may also lead to low functional capacity. Additionally, studies show that pain can cause sensitization in the contralateral patients' limb (46,47). Based on this assumption, the presence of claudication in one limb in our TAK patients could also cause "pseudo-claudication" in the contra-lateral patient's limb.…”

Section: Original Papermentioning

confidence: 57%

Is there an association between upper limb claudication and handgrip strength in Takayasu arteritis?

et al. 2021

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Limb vascular claudication and hand muscle weakness are common symptoms of Takayasu arteritis (TAK). However, no studies have correlated these two symptoms. Therefore, the aim of the study was to evaluate handgrip strength and its correlation with both upper-limb vascular claudication and imaging of the vessels. This cross-sectional study compared 36 patients with TAK who were matched by age, gender, and body mass index with 36 individuals without TAK (CTR). Hand strength (assessed with handgrip dynamometer), functional capacity (Health Assessment Questionnaire, HAQ), upper-limb vascular claudication symptoms (patients’ selfreported form), and disease activity (Indian Takayasu Clinical Activity Score [ITAS] 2010; Physician Global Assessment [PGA], C-reactive protein, and erythrocyte sedimentation rate) were evaluated as well as vessel imaging (e.g., angiotomography or angioresonance) and blood pressure. The median age of the patients was 42.0 years (35.5-51.5 years), whereas the mean disease duration was 13.1±6.8 years. No patient had active disease. Compared to the CTR, the patients with TAK showed reduced strength in the left-hand (22.9±5.9 vs 26.3±5.6 kg; p=0.014) and increased HAQ scores [0.50 (0.12-0.87) vs 0.00 (0.00-0.00); p<0.001]. Both groups had comparable blood pressure. Among patients with TAK, lefthand strength was inversely correlated with HAQ (Spearman correlation: rho=–0.584; p<0.001) and positively correlated with right-hand strength (rho=0.644; p<0.001). Moreover, neither hand’s strengths in the patients were correlated with subclavian stenosis imaging, blood pressure or limb vascular claudication. The reduction of strength in the upper left limb is inversely related to the functional capacity (HAQ score) of TAK. This reduction appears unrelated to classical vascular claudication, vessel imaging or blood pressure.

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“…delayed-onset muscle soreness). Furthermore, it has been demonstrated that an initial bout of eccentric exercise causes NFR facilitation, whereas no changes in the NFR were observed following a repeated bout of exercise (Hosseinzadeh et al, 2013(Hosseinzadeh et al, , 2015. Hence, regular eccentric training seems to facilitate intrinsic protective spinal processes against the development of muscle soreness leading to normalization of spinal nociception.…”

Section: Discussionmentioning

confidence: 99%

The influence of physical activity on the nociceptive flexion reflex in healthy people

Dhondt

Danneels

Oosterwijck

et al. 2020

European Journal of Pain

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Background: The nociceptive flexion reflex (NFR) is a spinal reflex induced by painful stimuli resulting in an appropriate withdrawal response. The NFR is considered to be an objective physiological correlate of spinal nociception. Previous research has already demonstrated that physical activity (PA) can influence pain assessments. To date, no studies have directly examined the relationship between PA and spinal nociception. Hence, this study aimed to investigate whether the NFR threshold can be predicted by report-based and monitor-based measures of PA in healthy adults. Methods: PA and the NFR threshold of 58 healthy adults were assessed. PA was evaluated by self-report using the International Physical Activity Questionnaire and by monitor-based accelerometry data. The NFR threshold was elicited through transcutaneous electrical stimulation of the sural nerve and quantified by the biceps femoris muscle electromyogram. Hierarchical linear regression analyses were performed to determine the relationship between PA and the NFR, while controlling for confounders. Results: Monitor-based measured step count and activities of moderate-to vigorousintensity predicted the NFR threshold accounting for 23.0% (p = .047) to 37.1% (p = .002) of the variance. Larger amounts of step counts and higher participation in moderate-to vigorous-intensity activities predicted higher NFR thresholds. Monitorbased activities of sedentary intensity predicted the NFR threshold accounting for 35.8% (p = .014) to 35.9% (p = .014) of the variance. Spending more time per day on activities of sedentary intensity predicted lower NFR thresholds. Conclusions: The study provides preliminary evidence indicating that a physically active lifestyle may reduce spinal nociception in healthy adults, while a sedentary lifestyle enhances spinal nociception. Significance: The present study provides preliminary evidence that the influencing effects of physical activity on pain are the result of a strong descending control and do not purely rely on supraspinal mechanisms. These study results highlight the importance of considering physical activity levels when evaluating nociceptive processing, | 775

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Ipsilateral resistance exercise prevents exercise-induced central sensitization in the contralateral limb: a randomized controlled trial

Abstract: These results suggest that contralateral RBE was associated with spinal facilitation of the neuronal pathways situated at a homologous innervation level, and it is unlikely that oxygen re-perfusion improvement plays a major role in the contralateral RBE.

Cited by 15 publications

References 47 publications

The repeated bout effect can occur without mechanical and neuromuscular changes after a bout of eccentric exercise

The repeated bout effect can occur without mechanical and neuromuscular changes after a bout of eccentric exercise

Is there an association between upper limb claudication and handgrip strength in Takayasu arteritis?

The influence of physical activity on the nociceptive flexion reflex in healthy people

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